DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ArfGAP3 and APPL2

DIOPT Version :9

Sequence 1:	NP_001097664.2	Gene:	ArfGAP3 / 40487	FlyBaseID:	FBgn0037182	Length:	553	Species:	Drosophila melanogaster
Sequence 2:	NP_001238833.1	Gene:	APPL2 / 55198	HGNCID:	18242	Length:	670	Species:	Homo sapiens

Alignment Length:	395	Identity:	79/395 - (20%)
Similarity:	122/395 - (30%)	Gaps:	136/395 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 VHRNL---GVHLTFVRSTNLDTNWTWLQLRQMQLGGN-------ANAAQFFR-AHNCSTTDAQVK 108
            ::|||   ..:|.....|.|.|. ||.:|.....|||       |.|....: ..|||.
Human   279 INRNLIQKAGYLNLRNKTGLVTT-TWERLYFFTQGGNLMCQPRGAVAGGLIQDLDNCSV------ 336

  Fly   109 YNSRAAQLYRDKLCAQAQQAMKTHGTKLHLEQTDKSEGNEAAREEDFFAQCDNEVDFNVQNNNVS 173
               .|......:.|.|........|..|..|...::|                  ::....||:|
Human   337 ---MAVDCEDRRYCFQITTPNGKSGIILQAESRKENE------------------EWICAINNIS 380

  Fly   174 KQ---DPNPPTVA------------PVISV-ETQQGGAPSVNLLNS--------VVPAAVPS--- 211
            :|   ..||..||            |:.|. :.|:...||.||.||        :||.|..|
Human   381 RQIYLTDNPEAVAIKLNQTALQAVTPITSFGKKQESSCPSQNLKNSEMENENDKIVPKATASLPE 445

  Fly   212 -------------------------SIGARKVQPKKGGLGARK-----------------VGGLG 234
                                     :.|:|:..|    .|..:                 |..||
Human   446 AEELIAPGTPIQFDIVLPATEFLDQNRGSRRTNP----FGETEDESFPEAEDSLLQQMFIVRFLG 506

  Fly   235 ATKVKTNFADIEARANAANEMKTSAAAAPVVKPQTAEDELETVASMRLAYQELSMQKTREEAKLK 299
            :..|||: :..|....|..::..:.|...:.: .|....:.|..|:||.  :...|.:|...:|.
Human   507 SMAVKTD-STTEVIYEAMRQVLAARAIHNIFR-MTESHLMVTSQSLRLI--DPQTQVSRANFELT 567

  Fly   300 TMDPAKAKQMERLGMGF--------------------NLRGSDMAHSALGDMETIQQSAAPKAKL 344
            ::....|.|..:..:||                    |..|..:.::.....|.|:....|:|..
Human   568 SVTQFAAHQENKRLVGFVIRVPESTGEESLSTYIFESNSEGEKICYAINLGKEIIEVQKDPEALA 632

  Fly   345 SLLES 349
            .|:.|
Human   633 QLMLS 637

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ArfGAP3	NP_001097664.2	ArfGap	17..121	CDD:214518	19/76 (25%)
APPL2	NP_001238833.1	BAR_APPL2	20..240	CDD:153316
		BAR-PH_APPL	258..382	CDD:270067	28/130 (22%)
		PTB_APPL	488..621	CDD:269980	23/136 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	649..670
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900