DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ArfGAP3 and Arfgap3

DIOPT Version :9

Sequence 1:	NP_001097664.2	Gene:	ArfGAP3 / 40487	FlyBaseID:	FBgn0037182	Length:	553	Species:	Drosophila melanogaster
Sequence 2:	NP_001037738.1	Gene:	Arfgap3 / 503165	RGDID:	1560066	Length:	525	Species:	Rattus norvegicus

Alignment Length:	570	Identity:	221/570 - (38%)
Similarity:	304/570 - (53%)	Gaps:	74/570 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 PSKQEIESVFSRLRAQPANKSCFDCAAKAPTWSSVTYGIFICIDCSAVHRNLGVHLTFVRSTNLD 72
            ||||:|.::|.|||:.|.||.||||.||.|:|:|::||:|:|||||..||:|||||:|:|||.||
  Rat     4 PSKQDILAIFKRLRSVPTNKVCFDCGAKNPSWASISYGVFLCIDCSGSHRSLGVHLSFIRSTELD 68

  Fly    73 TNWTWLQLRQMQLGGNANAAQFFRAHNCSTTDAQVKYNSRAAQLYRDKLCAQAQQAMKTHGTKLH 137
            :||:|.|||.||:||||||:.||..|.|:|.|...|||||||||||:|:...|.||.:.|||.|.
  Rat    69 SNWSWFQLRCMQVGGNANASSFFHQHGCATKDTNAKYNSRAAQLYREKIKTLATQATRRHGTDLW 133

  Fly   138 LEQTDKSEGNEAAREEDFFAQCDNEVDFNVQNNNVSKQDPNPPTVAP---VISVETQQGG---AP 196
            |:.......:...:||||||   :.....|.....:...|.|.:..|   ..:.|..:||   .|
  Rat   134 LDSCAAPPASPPPKEEDFFA---SHASLEVSGATQASAQPEPASSTPWGLETTPEKHEGGPGQGP 195

  Fly   197 SVNLLNS---VVPAAVPSSIGARKVQPKKGGLGARKVGGLGATKV-KTNFADIEARANAANEMKT 257
            ||..||:   ..||.|.|.|..:..|.|| ||||:| |.|||.|: .|:|.:||.:|.|.::.|.
  Rat   196 SVEGLNTPGKTAPAEVSSIIKKKPNQAKK-GLGAKK-GSLGAQKLTNTSFTEIEKQAQAVDKRKE 258

  Fly   258 SAAAAPVVKPQTAEDELETVASMRLAYQELSMQKTREEAKLKTMDPAKAKQMERLGMGFNLRGSD 322
            ....|     :....|...|:|:||||::|.:.|.::| :|......|| :.|||||||......
  Rat   259 QEDLA-----RGTPKEESIVSSLRLAYKDLEIHKKQDE-RLNLSGQKKA-EAERLGMGFGSCRGG 316

  Fly   323 MAHSALGDMETIQQS----AAPKAKLSLLESENFFTDFSLYGNSSSGGGGGGSSEKRESSVGGTS 383
            ::||...||:||:|.    |.|:.|......:::|:..|.:...||                  |
  Rat   317 ISHSVTSDMQTIEQESPTLAKPRRKYQEDPEDSYFSSSSKWSEQSS------------------S 363

  Fly   384 KL--DKFELDALGYETIEPIGGSHSNITSMFSRSNDY---DKPKTSAPVKKNSGSS-QTHTKGGT 442
            :.  |..||.:             |:.:|....::.|   |..:...|..|::||| :..::...
  Rat   364 RYFDDPMELRS-------------SHFSSWDDSADSYWKKDSSRDPEPATKSTGSSDRPSSRRKP 415

  Fly   443 STDPV----IAQQKFGNSKGFGSDQYFA-SEQSSADVSASLNRFQGSRAISSSDYFGDGSPGGTG 502
            ..:||    .||:||||.|...||.||. ..|:..:..|.|.|...|.:|||:|.|.:.....||
  Rat   416 EYEPVGNTDEAQKKFGNVKAISSDMYFGIQSQTDFETRARLERLSTSSSISSADLFDEQRKQTTG 480

  Fly   503 GNRASSVNFSAPDLDVESVKESVRQGVHKVAGRLSNLANDVMTSWQDKYG 552
            ....|:|..:|||:      ...:|||..|||:||..||.||||.||:||
  Rat   481 NYNLSNVLPNAPDM------AQFKQGVRSVAGKLSVFANGVMTSIQDRYG 524

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ArfGAP3	NP_001097664.2	ArfGap	17..121	CDD:214518	68/103 (66%)
Arfgap3	NP_001037738.1	PLN03114	1..488	CDD:178661	199/526 (38%)
		ArfGap	11..121	CDD:279720	69/109 (63%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	160..233		26/74 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	249..271		5/26 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	293..364		24/89 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	377..428		11/50 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	173	1.000	Domainoid score	I3598
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	330	1.000	Inparanoid score	I2368
OMA	1	1.010	-	-		QHG52037
OrthoDB	1	1.010	-	-		D1155557at2759
OrthoFinder	1	1.000	-	-		FOG0001852
OrthoInspector	1	1.000	-	-		otm44572
orthoMCL	1	0.900	-	-		OOG6_101784
Panther	1	1.100	-	-	LDO	PTHR45686
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1214
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.980