DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ArfGAP3 and ArfGAP1

DIOPT Version :9

Sequence 1:	NP_001097664.2	Gene:	ArfGAP3 / 40487	FlyBaseID:	FBgn0037182	Length:	553	Species:	Drosophila melanogaster
Sequence 2:	NP_524040.2	Gene:	ArfGAP1 / 39417	FlyBaseID:	FBgn0020655	Length:	468	Species:	Drosophila melanogaster

Alignment Length:	571	Identity:	139/571 - (24%)
Similarity:	207/571 - (36%)	Gaps:	176/571 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MASPAAGPSKQEIESVFSRLRAQPANKSCFDCAAKAPTWSSVTYGIFICIDCSAVHRNLGVHLTF 65
            ||||       ....|...|:.|..|..||:|....|.|.||||||:||::||..||:|||||:|
  Fly     1 MASP-------RTRRVLQELKPQDENSKCFECGTHNPQWVSVTYGIWICLECSGKHRSLGVHLSF 58

  Fly    66 VRSTNLDTNWTWLQLRQMQLGGNANAAQFFRAHNCSTTDAQV--KYNSRAAQLYRDKLCAQAQQA 128
            |||..:| .|..::|.:|:.|||.||.:|..........|.:  :|||:||.|||||:...||
  Fly    59 VRSVTMD-KWKDIELEKMKAGGNRNAREFLEDQEDWNERAPITQRYNSKAAALYRDKIATLAQ-- 120

  Fly   129 MKTHGTKLHLEQTDKSEGNEAAREEDFFAQCDNEVDFNVQNNNVSKQDPNPPTVAPVISVETQQG 193
                |....|::.....|:            :|.......:|:..:..|:          .|..|
  Fly   121 ----GKSWDLKEAQGRVGS------------NNSFSSGGSSNSSYQSRPS----------ATGYG 159

  Fly   194 GAPSVNLLNSVVPAA---------------------VPSSIGARKVQPKKGGLGARKVGGLGATK 237
            |...........|..                     |.::.....:.|.:||    |..|.|.|:
  Fly   160 GNGGYQNGGGAEPGGYQQYQTQEFKDQKEEFFSRRQVENASRPENLPPSQGG----KYAGFGFTR 220

  Fly   238 ---VKTNFAD-----IEARANAANEMKTSAAAAPVVKPQTAEDELETVASMRLAYQELSMQKTRE 294
               .||...:     :...|:..:...|:|:..    ..||:::..|..:       |:..|.:|
  Fly   221 EPPPKTQSQELFDSTLSTLASGWSLFSTNASKL----ASTAKEKAVTTVN-------LASTKIKE 274

  Fly   295 EAKLKTMD------PAKAKQMERLGMGFNLRGSDMAHSALGDMETIQQSAAPKAKLSLLESENFF 353
            ...|.::.      .:|...|.:.|.. ||.||:::....|                  .::..|
  Fly   275 GTLLDSVQCGVTDVASKVTDMGKRGWN-NLAGSNISSPQGG------------------YNDPNF 320

  Fly   354 TDFSLYGNSSSGGGG-----GGSSEKRESSVGGTSKLDKFELDALGYETIEPIGGSHSNITSMFS 413
            .|.|.|..|:|.||.     |..|...:|..||.                :..|.|.|::||..|
  Fly   321 EDSSAYQRSNSVGGNLAGGLGQQSGVSDSDWGGW----------------QDNGNSKSHMTSSSS 369

  Fly   414 RSNDYDKPKTSAPVKKNSGSSQTHTKGGTSTDPVIAQQKFGNSKGFGSDQYFASEQSSADVSASL 478
            ..|.         :..:||       |||:            |.|...|         ||.|.
  Fly   370 YHNQ---------LSSSSG-------GGTA------------SAGLTRD---------ADWSG-- 395

  Fly   479 NRFQGSRAISSSDYFGDGSPGGTGGNR-------ASSVNFSAPDLDVESVK 522
              |:.:...||...:.:.|.||:...|       :..::.....|||:|||
  Fly   396 --FEATNYQSSETSYQNASSGGSTARRNMKLQDTSQKLSEGFESLDVKSVK 444

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ArfGAP3	NP_001097664.2	ArfGap	17..121	CDD:214518	49/105 (47%)
ArfGAP1	NP_524040.2	ArfGap	7..114	CDD:279720	49/107 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45464125
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1155557at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.750