Protein Alignment ArfGAP3 and Appl2

DIOPT Version :9

• Sequence 1: NP_001097664.2
• Gene: ArfGAP3 / 40487
• FlyBaseID: FBgn0037182
• Length: 553
• Species: Drosophila melanogaster
• Sequence 2: NP_001102211.1
• Gene: Appl2 / 362860
• RGDID: 1563028
• Length: 662
• Species: Rattus norvegicus
• Alignment Length: 455
• Identity: 91/455 - (20%)
• Similarity: 153/455 - (33%)
• Gaps: 129/455 - (28%)

  Fly     9 SKQEIESVFSRLRAQPANKSCFDCAAKAPTWSSVTYGIFICIDCSAVHRNL----GVHLTFVRST 69
            |:||:.||                       |...|...|.:....::|||    | :|.....|
  Rat   250 SQQELLSV-----------------------SESVYTPDIDVATPQINRNLIQKTG-YLNLRNKT 290

  Fly    70 NLDTNWTWLQLRQMQLGGN-------ANAAQFFR-AHNCS--TTDAQ----------------VK 108
            .|.|. ||.:|.....|||       |.|....: ..|||  ..|.:                :.
  Rat   291 GLVTT-TWERLYFFTQGGNLMCQPRGAVAGGLIQDLDNCSVMAVDCEDRRYCFQISTPSGKPGII 354

  Fly   109 YNSRAAQLYRDKLCA-------------QAQQAMKTHGTKLHLEQTDKSEGNEAAREEDFFAQCD 160
            ..:.:.:.|.:.:||             ....|:|.:.|.|.......|.|.:  :|..:|:|
  Rat   355 LQAESRKEYEEWICAINNISRQIYLTDNPEAVAIKLNQTALQAVTPITSFGKK--QESFYFSQ-- 415

  Fly   161 NEVDFNVQNNNVSKQDPNPPTVAPVISVETQQGGAPSVNL-LNSVVPAA--VPSSIGARKVQPKK 222
                 |::|::.......|...|.:  .||::..||...: .:.|:||.  :..:.|:|::.|
  Rat   416 -----NIKNSDTGYVKIVPKAAASI--PETEELIAPGTPIQFDIVLPATEFLDQNRGSRRINP-- 471

  Fly   223 GGLGARK-----------------VGGLGATKVKTNFADIEARANAANEMKTSAAAAPVVKPQTA 270
              .|..:                 |..||:..|||: :..|....|..::..:.|...:.:  |.
  Rat   472 --FGETEDDSFPDAEDSLLQQMFIVRFLGSMAVKTD-STTEVIYEAMRQVLAARAIHNIFR--TT 531

  Fly   271 EDELETVASMRLAYQELSMQKTREEAKLKTMDPAKAKQMERLGMGF------------------- 316
            |..| .|.|..|...:...|.:|...:|.::....|.|..:..:||
  Rat   532 ESHL-MVTSQTLRLIDPQTQVSRACFELTSVTQFAAHQENKRLVGFVIRVPESTGEESLSTYIFE 595

  Fly   317 -NLRGSDMAHSALGDMETIQQSAAPKAKLSLLESENFFTD--FSLYGNSSSGGGGGGSSEKRESS 378
             |..|..:.::.....|.|:....|:|...|:.|.....|  :.|..:.:...||..|..:...|
  Rat   596 SNSEGEKICYAINLGKEIIEVQKDPEALARLMLSVPLTNDGKYVLLNDQADDTGGSPSDHRGAES 660

  Fly   379  378
              Rat   661  660

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ArfGAP3	NP_001097664.2	ArfGap	17..121	CDD:214518	24/133 (18%)
Appl2	NP_001102211.1	BAR_APPL2	20..234	CDD:153316
		BAR-PH_APPL	252..376	CDD:270067	30/148 (20%)
		PTB_APPL	480..613	CDD:269980	24/136 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	643..662		4/18 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900