DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ArfGAP3 and CG8243

DIOPT Version :9

Sequence 1:	NP_001097664.2	Gene:	ArfGAP3 / 40487	FlyBaseID:	FBgn0037182	Length:	553	Species:	Drosophila melanogaster
Sequence 2:	NP_610424.1	Gene:	CG8243 / 35890	FlyBaseID:	FBgn0033349	Length:	517	Species:	Drosophila melanogaster

Alignment Length:	579	Identity:	133/579 - (22%)
Similarity:	220/579 - (37%)	Gaps:	155/579 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MASPAAGPS----KQEIESVFSRLRAQPANKSCFDCAAKAPTWSSVTYGIFICIDCSAVHRNLGV 61
            |:|..||..    :::.:::.:::.....||.|.||.||.|.|:|...|:|:||.|:.:||||||
  Fly     1 MSSSNAGQRTKLIQEKCQTLLTQMLRDEDNKYCVDCDAKGPRWASWNLGMFLCIRCAGIHRNLGV 65

  Fly    62 HLTFVRSTNLDTNWTWLQLRQMQLGGNANAAQFFRAHNCSTTDAQVKYNSRAAQLYRDKLCAQAQ 126
            |::.|:|.|||| ||..|:..:|..||:.|...:        :||:....|..|  .|.......
  Fly    66 HISRVKSVNLDT-WTPEQVISLQQMGNSRARAVY--------EAQLPDGFRRPQ--TDTALENFI 119

  Fly   127 QAMKTHGTKLHLEQTDKSEGNEAAREEDFFAQCDNEVDFNVQNNNVSKQDPNPPTVAPVI--SVE 189
            :|...|...|..|....|     ..:.|:..:.|.|:: ..:....|.|......:|.|.  |.:
  Fly   120 RAKYEHKKYLAREWVPPS-----PPKVDWAKEIDEELE-RQKRKKKSTQAQATLGLAGVAGGSGD 178

  Fly   190 TQQGGAPSVNLLNSVVPAAVPSSIGARKVQPKKGGLGARKVGGLG---ATKVKTNFADIEARANA 251
            .:..|:.:..|.|:.:||.:|        :||     ..:|||..   ..:|:.|.:.:.: |..
  Fly   179 KRLSGSSASALKNTPLPAPLP--------KPK-----PNQVGGCSPKTTQRVQLNSSGVSS-AGE 229

  Fly   252 ANEMKTSAAAAPVVKPQTAED-ELETVASMRLAYQELSMQKTREEAKLKTMDPAKAKQMERLGMG 315
            ::.:..|:...|:|....::| :.|:..|. |:.:.::.|..              |.:...|..
  Fly   230 SDLLGLSSPTKPIVATNASQDLQNESFTSF-LSAESIAGQPD--------------KPIGSNGDA 279

  Fly   316 FNLRGSDMAHSALGDMETIQQSAAPKAKLSLLESENFFTDFSLYGNSSSGGGGGGSSEKRESSVG 380
            .||.||                   |......|.::||...||         |.|.:||.:|
  Fly   280 ANLMGS-------------------KPNSLAQEEQDFFNQGSL---------GAGGNEKDQS--- 313

  Fly   381 GTSKLDKFELDAL---------------GYETIEPIGGSHS--------------NITSMFSRSN 416
              .|:.|..:.||               |:..:.|.|..|.              |..||
  Fly   314 --GKMSKDSILALYGSAPATHNPQMNFGGFTGMAPGGYMHQQQQQQIPHQFMTPPNSVSM----- 371

  Fly   417 DYDKPKTSAPVKKNSGSSQTHTKGGTSTDPVIAQQKFGNSKGFGSDQY---FASEQSSADVSASL 478
             |:.|..:||...::.:..:.|           ....|.|.||...|:   ..|..::|..:|:.
  Fly   372 -YNSPVMAAPNAFSNAAISSAT-----------AMSMGGSHGFTGAQFPSTGGSPYAAAGQAAAT 424

  Fly   479 NRFQGSRAISSSDYFGDGSPGGTGGNRASSVNFSAPDLDVESVKESVRQGVHKVAGRLS 537
            |..|.:::|.|      |.|           .|.|.....:..::.::|..|...|.||
  Fly   425 NLMQTNQSILS------GMP-----------LFGAVPQQQQQHQQQLQQQHHPQLGGLS 466

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ArfGAP3	NP_001097664.2	ArfGap	17..121	CDD:214518	40/103 (39%)
CG8243	NP_610424.1	ArfGap	18..132	CDD:279720	43/124 (35%)
CG8243	NP_610424.1	COG5347	20..300	CDD:227651	85/344 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45464131
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.740