DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ArfGAP3 and Agap1

DIOPT Version :9

Sequence 1:	NP_001097664.2	Gene:	ArfGAP3 / 40487	FlyBaseID:	FBgn0037182	Length:	553	Species:	Drosophila melanogaster
Sequence 2:	NP_835220.1	Gene:	Agap1 / 347722	MGIID:	2653690	Length:	857	Species:	Mus musculus

Alignment Length:	167	Identity:	47/167 - (28%)
Similarity:	68/167 - (40%)	Gaps:	45/167 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 LRAQPANKSCFDCAAKAPTWSSVTYGIFICIDCSAVHRNLGVHLTFVRSTNLDTNWTWLQLRQMQ 84
            :|....|..|.||..:.|.|:|:..|..:||:||.:|||||.||:.|||.:|| :|....::.|.
Mouse   615 IRNMRGNSHCVDCDTQNPNWASLNLGALMCIECSGIHRNLGTHLSRVRSLDLD-DWPMELIKVMS 678

  Fly    85 LGGNANAAQFFRAHNCSTTD-------------AQVKYN-------------SRAAQLYRDKLCA 123
            ..||..|...:...:...|.             .:.||.             |...||.|    |
Mouse   679 SIGNELANSVWEEGSQGRTKPSLDSTREEKERWIRAKYEQKLFLAPLPCTEFSLGQQLLR----A 739

  Fly   124 QAQQAMKT------HGTKLHLEQTDKSEGNEAAREED 154
            .|::.::|      ||:        :.|.||...|.|
Mouse   740 TAEEDLRTVILLLAHGS--------RDEVNETCGEGD 768

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ArfGAP3	NP_001097664.2	ArfGap	17..121	CDD:214518	37/126 (29%)
Agap1	NP_835220.1	Small GTPase-like	66..276
		Centaurin_gamma	72..229	CDD:133303
		RAS	73..235	CDD:214541
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	267..342
		PH_AGAP	344..592	CDD:241281
		PH	347..>411	CDD:278594
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	407..431
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	497..547
		ArfGap	611..725	CDD:279720	33/110 (30%)
		Ank_2	736..826	CDD:289560	12/45 (27%)
		ANK	736..>825	CDD:238125	12/45 (27%)
		ANK repeat	768..799	CDD:293786	1/1 (100%)
		ANK 1	768..797		1/1 (100%)
		ANK 2	801..830
		ANK repeat	801..826	CDD:293786
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900