DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ArfGAP3 and AGFG2

DIOPT Version :9

Sequence 1:	NP_001097664.2	Gene:	ArfGAP3 / 40487	FlyBaseID:	FBgn0037182	Length:	553	Species:	Drosophila melanogaster
Sequence 2:	XP_005250363.1	Gene:	AGFG2 / 3268	HGNCID:	5177	Length:	492	Species:	Homo sapiens

Alignment Length:	549	Identity:	114/549 - (20%)
Similarity:	173/549 - (31%)	Gaps:	166/549 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 PAAGPS--KQEIESVFS----RLR-----AQPANKSCFDCAAKAPTWSSVTYGIFICIDCSAVHR 57
            |..|.|  |.|.|:...    |:|     :|..|:.||:||.:..|:..:|.|.|:|..||.:.|
Human    11 PGGGVSGGKAEAEAASEVWCRRVRELGGCSQAGNRHCFECAQRGVTYVDITVGSFVCTTCSGLLR 75

  Fly    58 NLG-VHLTFVRSTNLDTNWTWLQLRQMQLGGNANAAQFFRAHNCSTTDAQVKYNSRAAQLYRDKL 121
            .|. .|.  |:|.:: |.:|..::..:|..||                               ::
Human    76 GLNPPHR--VKSISM-TTFTEPEVVFLQSRGN-------------------------------EV 106

  Fly   122 CAQAQQAMKTHGTKLHLEQTDKSEGNEAARE----EDFFAQCDNEVDFNVQNNNVSKQDPNPPTV 182
            |.:....:....|.|..:..|..:..|..:|    :.::...|     .|:....:|...:.|..
Human   107 CRKIWLGLFDARTSLVPDSRDPQKVKEFLQEKYEKKRWYVPPD-----QVKGPTYTKGSASTPVQ 166

  Fly   183 APVIS---VETQQGG-APSVNLLNSVVPAAVPSSIG----ARKVQPKKGGLGARKVGGLGATKVK 239
            ..:..   :.|..|. |||:::..|.....|..|..    ||..||....         ...|..
Human   167 GSIPEGKPLRTLLGDPAPSLSVAASTSSQPVSQSHARTSQARSTQPPPHS---------SVKKAS 222

  Fly   240 TN-FADIEARANAANEMKTSAAAAPVVKPQTAEDELETVASMRLAYQELSMQKTREEAKLKTMDP 303
            |: .|||.....||.:|..:.||.|....||                                 |
Human   223 TDLLADIGGDPFAAPQMAPAFAAFPAFGGQT---------------------------------P 254

  Fly   304 AKAKQMERLGM-GFNLRGSDMAHSALGDM-----ETIQQSAAPKAKLSLLESENFFTDFSLYGNS 362
            ::.      |. .|:...|..:.|..|.:     .:.|....|.|...|.||.:|        .|
Human   255 SQG------GFANFDAFSSGPSSSVFGSLPPAGQASFQAQPTPAASRMLTESYSF--------GS 305

  Fly   363 SSGGGGGGSSEKRESSVGGTSKLDKFELDALGYETIEPIGGSHSNITSMFSRSNDYDKPKTSAPV 427
            |.|...|.:.....|.....:.:..|    ||...  |..|..|::..|..:     .|...:..
Human   306 SQGTPFGATPLAPASQPNSLADVGSF----LGPGV--PAAGVPSSLFGMAGQ-----VPPLQSVT 359

  Fly   428 KKNSGSSQTHTKGGTSTDPVIAQQKFGNSKGFGSDQYFASEQSSADVSASLNRFQGSR------- 485
            ....|.|.|....|..|:|..|                .:.||..   .|.|.||.:.
Human   360 MGGGGGSSTGLAFGAFTNPFTA----------------PAAQSPL---PSTNPFQPNGLAPGPGF 405

  Fly   486 AISSSDYFGDGSPGGTGGNRASSVNFSAP 514
            .:||:   |.|.|.......|.:.:|.||
Human   406 GMSSA---GPGFPQAVPPTGAFASSFPAP 431

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ArfGAP3	NP_001097664.2	ArfGap	17..121	CDD:214518	25/113 (22%)
AGFG2	XP_005250363.1	ArfGap	40..147	CDD:295313	29/140 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900