Protein Alignment ArfGAP3 and AGFG1

DIOPT Version :9

• Sequence 1: NP_001097664.2
• Gene: ArfGAP3 / 40487
• FlyBaseID: FBgn0037182
• Length: 553
• Species: Drosophila melanogaster
• Sequence 2: NP_001128659.1
• Gene: AGFG1 / 3267
• HGNCID: 5175
• Length: 584
• Species: Homo sapiens
• Alignment Length: 635
• Identity: 134/635 - (21%)
• Similarity: 211/635 - (33%)
• Gaps: 184/635 - (28%)

  Fly     5 AAGPSKQEIESVFSRLR---AQPANKSCFDCAAKAPTWSSVTYGIFICIDCSAVHRNLG-VHLTF 65
            ||...:::.|.....||   ..|.|:.||||..:.||:.::|.|.|:|..||...|.|. .|.
Human     2 AASAKRKQEEKHLKMLRDMTGLPHNRKCFDCDQRGPTYVNMTVGSFVCTSCSGSLRGLNPPHR-- 64

  Fly    66 VRSTNLDTNWTWLQLRQMQLGGN--------------ANAAQFFRAHNCSTTDAQVKYNSR---- 112
            |:|.:: |.:|..::..:|..||              ::|...||.........|.||..:
Human    65 VKSISM-TTFTQQEIEFLQKHGNEVCKQIWLGLFDDRSSAIPDFRDPQKVKEFLQEKYEKKRWYV 128

  Fly   113 -------AAQLYRDKLCAQAQQAMKTHGTK------------LHLEQ--------TDKSEGNEAA 150
                   .|.::.....:.|.....|...|            |||.:        ..:|:|.:..
Human   129 PPEQAKVVASVHASISGSSASSTSSTPEVKPLKSLLGDSAPTLHLNKGTPSQSPVVGRSQGQQQE 193

  Fly   151 REE---------DFFA-------QCDNEVDFNVQNNNVSKQDPNPP----TVAPVISVETQQGGA 195
            :::         |.||       ...|..:|...|::.::...|..    ......|..:..||.
Human   194 KKQFDLLSDLGSDIFAAPAPQSTATANFANFAHFNSHAAQNSANADFANFDAFGQSSGSSNFGGF 258

  Fly   196 PSVN------------LLNSVVPAAVPSSIG----ARKVQPKKGGLGARKVGGLGATKVKTNFAD 244
            |:.:            :|:|      ..|.|    |..:|....|         .|..|..|||.
Human   259 PTASHSPFQPQTTAFRMLSS------SCSFGEFTSAFPLQATHSG---------SAASVNANFAH 308

  Fly   245 IEARANAANEMKTSAAAAPVVKPQTAEDELETVASMRLAYQELSMQKTREEAKLKTMDPA-KAKQ 308
            .:      |..|:|:|.....  .|::......|..:::..:..:|...:.|.|..:|.. .|.|
Human   309 FD------NFPKSSSADFGTF--NTSQSHQTASAVSKVSTNKAGLQTADKYAALANLDNIFSAGQ 365

  Fly   309 MERLGMGFNLRG----------------SDMAHSALGDMETIQQSAAPKAKLSLLESENFFTDFS 357
            ....|.||...|                |...::||.:::::..|||        .|.|.:|..|
Human   366 GGDQGSGFGTTGKAPVGSVVSVPSQSSASSDKYAALAELDSVFSSAA--------TSSNAYTSTS 422

  Fly   358 LYGNSSSGGGG------GGSSEKRESSV----GGT---------------SKLDKFELDALGYET 397
               |:||...|      ...::...|||    |.|               |..:.|:.:|.| .|
Human   423 ---NASSNVFGTVPVVASAQTQPASSSVPAPFGATPSTNPFVAAAGPSVASSTNPFQTNARG-AT 483

  Fly   398 IEPIGGSHSNITSMFSRSNDYDKPKTSAPVKKNSGSSQTHTKGGTSTDPVI-AQQKFGNSKGFGS 461
            ....|.:..::.:.|.....|..|.:.      |||.|         .|.. ||..|.....|..
Human   484 AATFGTASMSMPTGFGTPAPYSLPTSF------SGSFQ---------QPAFPAQAAFPQQTAFSQ 533

  Fly   462 D-QYFASEQSSADVSASLNRFQGSRAISSSDYFGDGSPGGTGGNRASSVN 510
            . ..||:...:..|.....  |.:.|..||:.|..|:|.|.....:||.|
Human   534 QPNGFAAFGQTKPVVTPFG--QVAAAGVSSNPFMTGAPTGQFPTGSSSTN 581

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ArfGAP3	NP_001097664.2	ArfGap	17..121	CDD:214518	33/132 (25%)
AGFG1	NP_001128659.1	COG5347	8..319	CDD:227651	68/334 (20%)
		ArfGap	14..135	CDD:214518	32/123 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900