DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ArfGAP3 and acap3a

DIOPT Version :9

Sequence 1:	NP_001097664.2	Gene:	ArfGAP3 / 40487	FlyBaseID:	FBgn0037182	Length:	553	Species:	Drosophila melanogaster
Sequence 2:	XP_021325699.1	Gene:	acap3a / 322991	ZFINID:	ZDB-GENE-030131-1711	Length:	845	Species:	Danio rerio

Alignment Length:	384	Identity:	81/384 - (21%)
Similarity:	144/384 - (37%)	Gaps:	97/384 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 ASP------AAGPSKQEI---ESVFSRLRAQPANKSCFDCAAKAPTWSSVTYGIFICIDCSAVHR 57
            |||      :|..|::..   |::..|:.:.|.|:.|.|||...|.|:|:..|:.:||:||.:||
Zfish   382 ASPSISSIDSASESRERSVRGENILQRILSLPGNQQCCDCAQTEPRWASINLGVLLCIECSGIHR 446

  Fly    58 NLGVHLTFVRSTNLDTNWTWLQLRQMQLGGNANAAQFFRAHNCSTTDAQVKYNSRAAQLYRDKLC 122
            :||||.:.|||..|| :|....|:.|...||:.....:..   |..:..:|..:..:.....:..
Zfish   447 SLGVHCSKVRSLTLD-SWEPELLKLMCELGNSIINHIYEG---SCEEQGLKKPAPNSSRQEKEAW 507

  Fly   123 AQAQQAMKTHGTKLHLEQTDKSEGNEAAREEDFFAQCDNEVDFNVQNNNVSKQDPNPPTVAPVIS 187
            .:|:...|....|:...:...:.|.::.|.               .|:...::..:..||.....
Zfish   508 IKAKYVEKKFLKKMMTGEVVVNGGRKSERR---------------WNSRKCRRHNSATTVPKTHR 557

  Fly   188 VETQQGGAPSVNLLNSVVPAAVPSSIGA--RKVQPKK---------------GGLGARKVGGL-- 233
            ...|..|:.|        ||.:.|:..|  ||.:.:.               .|.|.|...||
Zfish   558 KYRQDPGSAS--------PATLSSATAALERKFRRESLFCPDELDNLFSYFDTGSGPRSPTGLSS 614

  Fly   234 -----GATKVKTNFADIEARANAANEMKTSAAAAPVVKPQTAEDELETVASMRLAYQELSMQKTR 293
                 |:|...|:....|:..::..|.:     ..|.:..:.|.|||..||
Zfish   615 DSGLGGSTDGSTDVLVFESVVDSVTEEE-----CEVSEDSSNEAELEPEAS-------------- 660

  Fly   294 EEAKLKTMDPAKAKQMERLGMGFN--------LRGSDMAHSALGDMETIQQSAAPKAKL 344
                    ||..:::::...:.:.        :....:||.|  |:.::.:....|:.|
Zfish   661 --------DPEDSRELDAGALLYKACQARNLPVMAEALAHGA--DVNSVNEEDEGKSPL 709

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ArfGAP3	NP_001097664.2	ArfGap	17..121	CDD:214518	33/103 (32%)
acap3a	XP_021325699.1	BAR	16..215	CDD:325158
		PH_ACAP	271..367	CDD:270070
		ArfGap	403..520	CDD:307528	36/120 (30%)
		ANK	674..790	CDD:238125	6/38 (16%)
		ANK repeat	674..700	CDD:293786	4/27 (15%)
		ANK repeat	702..735	CDD:293786	2/8 (25%)
		ANK repeat	737..762	CDD:293786
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900