DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ArfGAP3 and Git2

DIOPT Version :9

Sequence 1:	NP_001097664.2	Gene:	ArfGAP3 / 40487	FlyBaseID:	FBgn0037182	Length:	553	Species:	Drosophila melanogaster
Sequence 2:	XP_006530402.1	Gene:	Git2 / 26431	MGIID:	1347053	Length:	761	Species:	Mus musculus

Alignment Length:	753	Identity:	142/753 - (18%)
Similarity:	231/753 - (30%)	Gaps:	305/753 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 RLRAQPANKSCFDCAAKAPTWSSVTYGIFICIDCSAVHRNLGVHLTFVRSTNLDTNW--TWLQLR 81
            |||:...   |.||....|:|:||..|.|||.:|.:|||:||.|::.||... .|.|  |.||:.
Mouse     4 RLRSSDV---CADCNGPDPSWASVNRGTFICDECCSVHRSLGRHISQVRHLK-HTAWPPTLLQMV 64

  Fly    82 QMQLGGNANA-----------------------------AQFFRA--------HN--CSTTD--- 104
            :......||:                             |:|.||        |.  |...|
Mouse    65 ETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRLPCREDDSVT 129

  Fly   105 ---------------------------AQVKY------------NSRAAQLYRDKLCA------- 123
                                       ||..:            .|:|.|:.:.:|.|
Mouse   130 AKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKGSTPLHVASKAGQILQAELLAVYGADPG 194

  Fly   124 -----------QAQQA----MKTHGTKLHLEQTDK------------------------------ 143
                       .|:|.    :.....::..|.||:
Mouse   195 TQDSSGKTPVDYARQGGHHELAERLIEIQYELTDRLAFYLCGRKPDHKSGQHFLIPQRADRRLSL 259

  Fly   144 --SEGNEAARE----------EDFFAQCDNEVD--------FNVQNNNVSKQDPNPPTVAPVISV 188
              ||..:||::          |:......:|||        ...||::....:   .||.|.:.|
Mouse   260 DLSELAKAAKKKLQSLSNHLFEELAMDVYDEVDRRETDAVWLATQNHSTLVTE---TTVVPFLPV 321

  Fly   189 -----ETQQGGAPSVNLLNSVVPAAVPSSIGARKVQPKKGG----------LGARKVGGLGATKV 238
                 .|:..|...:...|:...|.:...|.:...:.::|.          |..|.|....:|:.
Mouse   322 NPEYSSTRNQGRQKLARFNAHEFATLVIDILSDAKRRQQGSPLSRSKDNVELILRTVSTQHSTES 386

  Fly   239 KTN------------FADIEARANAANEMK---TSAAAAPVVKPQTAEDELETVASMRLAYQELS 288
            :.|            ..|:|.||:.||..|   :..:..||...:..|.:...|||
Mouse   387 QDNDQPDYDSVASDEDTDVETRASKANRQKSLDSDLSDGPVTVQEFMEVKSALVAS--------- 442

  Fly   289 MQKTREEAKLKTMDPAKAKQMERLGMGFNLRGSDMAHSALGDMETIQQSAAPKAKLSLLESENFF 353
                            :||:.:.:.:..||  ||       ::..:|:      ||..|:|||
Mouse   443 ----------------EAKRQQLMKVNNNL--SD-------ELRIMQK------KLQTLQSEN-- 474

  Fly   354 TDFSLYGNSSSGG-----------GGGGSSEKRESSVGGTSKLDKFELDALGYETIEPIG-GSHS 406
              .||...:::..           ....||.||..|..|:..:..:|..: |.:...|:| .||
Mouse   475 --SSLRRQATASACQVQTGSDHKDTASHSSLKRRPSARGSRPMSMYETGS-GQKPYLPMGEASH- 535

  Fly   407 NITSMFSRSNDYDKPKTS----APVKKNSGSSQTHTKGGTSTDPVIAQQKFGNSKGFGSDQYFAS 467
                          |:.|    .|...:.|.|...|  .:|:.|           .|.|...::.
Mouse   536 --------------PEESRTRLQPFPTHIGRSALVT--SSSSLP-----------SFPSTLSWSR 573

  Fly   468 EQSSADVSASLNRFQGSRAISSSDYFG---DGSPGGTGGNRA----------------SSVNFSA 513
            ::|:...|    |.:...:...|||..   |..|..||..|.                ::...|.
Mouse   574 DESARRAS----RLEKQNSTPESDYDNTACDPEPDDTGSTRKGRQRSMLWQGDGLLPDTAEPHSV 634

  Fly   514 PDLDVESVKESVRQGVHKVAGRLSNLANDVMTSWQDKY 551
            |...:.|.::.:|: ..::...:..|......:..|.|
Mouse   635 PSPTLPSTEDVIRK-TEQITKNIQELLRAAQENKHDSY 671

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ArfGAP3	NP_001097664.2	ArfGap	17..121	CDD:214518	42/184 (23%)
Git2	XP_006530402.1	ArfGap_GIT2	1..111	CDD:350072	34/110 (31%)
		Ank_2	137..229	CDD:372319	11/91 (12%)
		ANK repeat	137..165	CDD:293786	2/27 (7%)
		ANK repeat	167..197	CDD:293786	5/29 (17%)
		GIT_SHD	268..296	CDD:369921	5/27 (19%)
		GIT_SHD	332..360	CDD:369921	4/27 (15%)
		GIT_CC	416..480	CDD:374629	22/107 (21%)
		GIT1_C	640..754	CDD:371961	5/33 (15%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900