Protein Alignment ArfGAP3 and APPL1

DIOPT Version :9

• Sequence 1: NP_001097664.2
• Gene: ArfGAP3 / 40487
• FlyBaseID: FBgn0037182
• Length: 553
• Species: Drosophila melanogaster
• Sequence 2: NP_036228.1
• Gene: APPL1 / 26060
• HGNCID: 24035
• Length: 709
• Species: Homo sapiens
• Alignment Length: 521
• Identity: 97/521 - (18%)
• Similarity: 173/521 - (33%)
• Gaps: 176/521 - (33%)

  Fly    78 LQLRQM-QLGGNANAAQFFRAHNCS--TTDAQVK-------YNSRAAQ--------------LYR 118
            |.|::: |:..|.:.|...|....|  ..:.:||       |.||..|              .|:
Human   127 LTLKEVFQIASNDHDAAINRYSRLSKKRENDKVKYEVTEDVYTSRKKQHQTMMHYFCALNTLQYK 191

  Fly   119 DKLC--------AQAQQAMKTHGTKLHLEQTDKSEGNEAAREEDFFAQCDNEV--------DFNV 167
            .|:.        .|||.:....|::...||.::...|.....::...:.|:::        |..|
Human   192 KKIALLEPLLGYMQAQISFFKMGSENLNEQLEEFLANIGTSVQNVRREMDSDIETMQQTIEDLEV 256

  Fly   168 QNNNVSKQDPNPPTVAPVISVETQQGGAPSVNLLNSVVPAAVPSSIGARKVQPKKGG---LGAR- 228
            .::.:...||: ||..||....|::.|     .||:.....:.||...|:....:||   ..||
Human   257 ASDPLYVPDPD-PTKFPVNRNLTRKAG-----YLNARNKTGLVSSTWDRQFYFTQGGNLMSQARG 315

  Fly   229 -KVGGLG--ATKVKTNFADIEARANAANEMKTSAAAAPVVKPQTAEDELETVASMRLAYQELSMQ 290
             ..|||.  .........|.|.|.............:.:::.::.:|..|.:.::....:::.:.
Human   316 DVAGGLAMDIDNCSVMAVDCEDRRYCFQITSFDGKKSSILQAESKKDHEEWICTINNISKQIYLS 380

  Fly   291 KTREE-------AKLKTMDPAKAKQMERLGMGFNLRGSDMAHSALGDMETIQQSAAPKAKLSLLE 348
            :..||       :.|:.:.|:.:.|..              |.:|  .....||..|.|:
Human   381 ENPEETAARVNQSALEAVTPSPSFQQR--------------HESL--RPAAGQSRPPTAR----- 424

  Fly   349 SENFFTDFSLYGNSSSGGGGGGSSEKRESSVGGTSKLDKFELDAL-------GYETIEPIGGSHS 406
                        .||||..|..|           :.|....||:|       .::.|.|:
Human   425 ------------TSSSGSLGSES-----------TNLAALSLDSLVAPDTPIQFDIISPV----- 461

  Fly   407 NITSMFSRSNDYDKPKTSAPVKKNSGSSQTHTKGGTSTDPVIAQQKFGNSKGFGSDQYFASEQSS 471
                      ..|:|          |.::...:||..|:|      ||.|.|        |.:|.
Human   462 ----------CEDQP----------GQAKAFGQGGRRTNP------FGESGG--------STKSE 492

  Fly   472 ADVS----ASLNRFQGSRAISSSDYFGDGSPGGTGGNRASSVNFSAPDLDVESVKESV-RQGVHK 531
            .:.|    ..:.||.||..:.|.|:                     ||:..|::::.: .:.:|.
Human   493 TEDSILHQLFIVRFLGSMEVKSDDH---------------------PDVVYETMRQILAARAIHN 536

  Fly   532 V 532
            :
Human   537 I 537

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ArfGAP3	NP_001097664.2	ArfGap	17..121	CDD:214518	14/66 (21%)
APPL1	NP_036228.1	Required for RAB5A binding	1..428		62/339 (18%)
		BAR_APPL1	20..234	CDD:153315	22/106 (21%)
		BAR-PH_APPL	252..376	CDD:270067	27/129 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	397..434		13/69 (19%)
		F&H	403..414		3/26 (12%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	467..491		10/37 (27%)
		PTB_APPL	490..625	CDD:269980	12/69 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	645..709

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900