DRSC/TRiP Functional Genomics Resources

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Protein Alignment ArfGAP3 and Git1

DIOPT Version :9

Sequence 1:NP_001097664.2 Gene:ArfGAP3 / 40487 FlyBaseID:FBgn0037182 Length:553 Species:Drosophila melanogaster
Sequence 2:NP_001004144.1 Gene:Git1 / 216963 MGIID:1927140 Length:770 Species:Mus musculus


Alignment Length:503 Identity:104/503 - (20%)
Similarity:176/503 - (34%) Gaps:89/503 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly    21 RAQPANKSCFDCAAKAPTWSSVTYGIFICIDCSAVHRNLGVHLTFVRSTNLDTNW--TWLQLRQM 83
            |..|..:.|.||:|..|.|:|::.|:.:|.:|.:|||:||.|::.|:... .:.|  |.||:...
Mouse     3 RKGPRAEVCADCSAPDPGWASISRGVLVCDECCSVHRSLGRHISIVKHLR-HSAWPPTLLQMVHT 66

  Fly    84 QLGGNANAAQFFRAHNCSTTDAQVKYNSRAAQLYRDKL------CAQAQQAMKTHGTKLHLEQTD 142
            .....||:..    .:.....|||:...|.|. .:||:      ..:|:..|.....||.....|
Mouse    67 LASNGANSIW----EHSLLDPAQVQSGRRKAN-PQDKVHPIKSEFIRAKYQMLAFVHKLPCRDDD 126

  Fly   143 KSEGNEAARE------EDFFAQCDNEVDFNVQNNNVSKQDPNPPTVAPVISVETQQGGAPSVNLL 201
            .....:.:::      ......|...:....|.|....:....|     :.|..:.|......||
Mouse   127 GVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKGTTP-----LHVAAKAGQTLQAELL 186

  Fly   202 NSVVPAAVPSSIGARKVQPKKGGLG----ARKVG--GLGATKVKTNFADIEARANAANEMKTSAA 260
              ||..|.|.|       |...|..    ||:.|  .|....|:..:...:..|......|....
Mouse   187 --VVYGADPGS-------PDVNGRTPIDYARQAGHHELAERLVECQYELTDRLAFYLCGRKPDHK 242

  Fly   261 AAPVVKPQTAEDELETVASMRLAYQELSMQKTREEAKLKTMDPAKAKQMERLGMG----FNLRGS 321
            ....:.||.|:...:...|..|...||:      :|..|.:.....:..|.|.|.    .:.|.:
Mouse   243 NGHYIIPQMADRSRQKCMSQSLDLSELA------KAAKKKLQALSNRLFEELAMDVYDEVDRREN 301

  Fly   322 DMAHSALGDMETI--QQSAAP---------------KAKLSLLESENFFT---DFSLYGNSSSGG 366
            |....|..:..|:  ::||.|               :.||:...:..|.|   |..         
Mouse   302 DAVWLATQNHSTLVTERSAVPFLPVNPEYSATRNQGRQKLARFNAREFATLIIDIL--------- 357

  Fly   367 GGGGSSEKRESSVGGTSKLDKFELDALGYETIEPIGGSHSNITSMFSRSNDYDKPKTSAPVKKNS 431
               ..:::|:.....:|..|..||.|.....::    ...:..|:.|..:...:|..||...:|:
Mouse   358 ---SEAKRRQQGKSLSSPTDNLELSARSQSELD----DQHDYDSVASDEDTDQEPLPSAGATRNN 415

  Fly   432 GSSQTHTKGGTSTDPVIAQQKFGNSKGFGSDQYFASEQSSADVSASLN 479
             .:::......|...|..|:.....|...:.:  |..|....|::||:
Mouse   416 -RARSMDSSDLSDGAVTLQEYLELKKALATSE--AKVQQLMKVNSSLS 460

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ArfGAP3NP_001097664.2 ArfGap 17..121 CDD:214518 31/101 (31%)
Git1NP_001004144.1 Interaction with gamma-tubulin and localization to the centrosome. /evidence=ECO:0000250|UniProtKB:Q9Y2X7 1..124 36/126 (29%)
ArfGap_GIT1 1..111 CDD:350071 33/113 (29%)
ANK 1 132..161 2/28 (7%)
Ank_2 137..229 CDD:372319 20/105 (19%)
ANK repeat 137..165 CDD:293786 3/27 (11%)
ANK 2 166..195 9/35 (26%)
ANK repeat 167..197 CDD:293786 10/43 (23%)
ANK 3 199..228 6/28 (21%)
Interaction with PCLO. /evidence=ECO:0000250|UniProtKB:Q9Z272 245..374 26/146 (18%)
Interaction with PTK2/FAK1. /evidence=ECO:0000250|UniProtKB:Q9Z272 253..424 33/193 (17%)
Interaction with ARHGEF7. /evidence=ECO:0000250|UniProtKB:Q9Z272 254..376 24/139 (17%)
GIT_SHD <281..301 CDD:369921 4/19 (21%)
GIT_SHD 337..365 CDD:369921 6/39 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 363..425 12/66 (18%)
Interaction with NCK2 and GRIN3A. /evidence=ECO:0000250|UniProtKB:Q9Z272 375..596 18/93 (19%)
Required for localization at synapses. /evidence=ECO:0000250|UniProtKB:Q9Y2X7 375..596 18/93 (19%)
GIT_CC 418..482 CDD:374629 9/45 (20%)
Interaction with MAPK1. /evidence=ECO:0000269|PubMed:15923189 420..475 9/43 (21%)
Interaction with IKBKG. /evidence=ECO:0000250|UniProtKB:Q9Y2X7 429..629 8/34 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 578..615
Interaction with PXN and TGFB1I1. /evidence=ECO:0000250|UniProtKB:Q9Z272 646..770
GIT1_C 649..763 CDD:371961
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5347
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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