DRSC/TRiP Functional Genomics Resources

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Protein Alignment ArfGAP3 and Acap1

DIOPT Version :9

Sequence 1:NP_001097664.2 Gene:ArfGAP3 / 40487 FlyBaseID:FBgn0037182 Length:553 Species:Drosophila melanogaster
Sequence 2:NP_722483.2 Gene:Acap1 / 216859 MGIID:2388270 Length:740 Species:Mus musculus


Alignment Length:360 Identity:77/360 - (21%)
Similarity:125/360 - (34%) Gaps:85/360 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 AAGPSKQEIESVFSRLRAQPANKSCFDCAAKAPTWSSVTYGIFICIDCSAVHRNLGVHLTFVRST 69
            |.|.....:..|.:::::...|..|.||...||.|:|:..|:.:||.||.:||:||||.:.|||.
Mouse   396 ARGRESGGVGQVAAQVQSVDGNAQCCDCREPAPEWASINLGVTLCIQCSGIHRSLGVHFSKVRSL 460

  Fly    70 NLDTNWTWLQLRQMQLGGNANAAQFFRAH-----------NCSTTDAQVKYNSRAAQLYRDKLCA 123
            .|| :|....::.|...||....|.:.|.           :||..:.:...:::..:        
Mouse   461 TLD-SWEPELVKLMCELGNVIINQIYEARVEAMAVKKPGPSCSRQEKEAWIHAKYVE-------- 516

  Fly   124 QAQQAMKTHGTKLHLEQTDKSEGNEAAR-----------------------------EEDFFAQC 159
                       |..|.:..:..|....|                             .:|..:..
Mouse   517 -----------KKFLTKLPEIRGRRGGRGPPRGHPPVPPKPPIRPHSGIVRSKSECPSDDMGSLH 570

  Fly   160 DNEVDFNVQNNNVSKQDPNPPTVAPVIS-------VETQQGGAPSV---NLLNSVVPAAVPSSIG 214
            ...:.|....:     .|:.||:|..::       |...||.|..:   ...||::........|
Mouse   571 PGALLFQAAGH-----PPSLPTMADALAHGADVNWVNVGQGNATPLIRATAANSLLACEFLLQNG 630

  Fly   215 ARKVQPKKGGLG----ARKVG--GLGATKVKTNFADIEARANAANEMKTSA---AAAPVVKPQTA 270
            |...|....|.|    |..:|  ||....:|.. ||:.||.....:..|.|   ..|.:|.....
Mouse   631 ANVNQADSAGRGPLHHATILGHTGLACLFLKRG-ADLGARDTEGRDPLTIAMETTNADIVTLLRL 694

  Fly   271 EDELETVASMRLAYQELSMQKTREEAKLKTMDPAK 305
            ....|..|:...|..|..:...|:.:.:.:.||.|
Mouse   695 AKMREAEAAQGQAGDETYLDIFRDFSLMASDDPEK 729

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ArfGAP3NP_001097664.2 ArfGap 17..121 CDD:214518 32/114 (28%)
Acap1NP_722483.2 Required for formation of endosomal tubules when overexpressed with PIP5K1C. /evidence=ECO:0000250|UniProtKB:Q15027 1..382
BAR_ACAP1 18..217 CDD:153323
PH 266..360 CDD:278594
PH_ACAP 268..364 CDD:270070
Required for interaction with GULP1. /evidence=ECO:0000250|UniProtKB:Q15027 405..740 75/351 (21%)
ArfGap 406..519 CDD:279720 34/132 (26%)
Prevents interaction with ITGB1 when S-554 is not phosphorylated. /evidence=ECO:0000250 525..566 2/40 (5%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 525..562 2/36 (6%)
Ank_2 575..670 CDD:289560 24/100 (24%)
ANK repeat 575..602 CDD:293786 5/31 (16%)
ANK <592..692 CDD:238125 24/100 (24%)
ANK repeat 606..637 CDD:293786 7/30 (23%)
ANK repeat 639..670 CDD:293786 10/31 (32%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5347
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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