DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ArfGAP3 and cnt-1

DIOPT Version :9

Sequence 1:	NP_001097664.2	Gene:	ArfGAP3 / 40487	FlyBaseID:	FBgn0037182	Length:	553	Species:	Drosophila melanogaster
Sequence 2:	NP_001369802.1	Gene:	cnt-1 / 174848	WormBaseID:	WBGene00000565	Length:	826	Species:	Caenorhabditis elegans

Alignment Length:	359	Identity:	84/359 - (23%)
Similarity:	141/359 - (39%)	Gaps:	84/359 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 SPAAGPSKQEIESVFSRLRAQPANKSCFDCAAKAPTWSSVTYGIFICIDCSAVHRNLGVHLTFVR 67
            |.|||.|..  .:.|.::|..|.|:.|.||.:.||.|.|:..|:.:||:||..||:|||..:.||
Worm   438 STAAGFSSS--TTAFEQVRRVPGNEVCADCGSPAPKWVSINLGVVLCIECSGAHRSLGVQTSKVR 500

  Fly    68 STNLDT--NWTWLQLRQMQLG-GNANAAQFFRAHNCSTTDAQV--KYNSRAAQLYRDKLCAQAQQ 127
            |..:|:  |    :||.:.|. ||....:.|.|| ....|:.|  :.|.::|:..|:...
Worm   501 SLCMDSIDN----ELRDVLLALGNRQVNEIFLAH-LPPADSIVPPQINEKSARPAREAWI----- 555

  Fly   128 AMKTHGTKLHLEQTDKSEGNEAAREEDFFAQCDNEVDFNVQNNNVSKQDPNPPTVAPVISVETQQ 192
                                :|...|..||..:   |...:::..::|:.        :..:|..
Worm   556 --------------------KAKYVERRFAVAE---DTRARSSATNRQEH--------LKHKTSI 589

  Fly   193 GGAPSVNLLNSVVPAAVPSSIGARKVQPKKGGLGARKVGGLGATKVKTNFADIEARANAANEMKT 257
            ||..|.|.:|.       ||..|.....:.|||       |.|....   ||:......|:: :.
Worm   590 GGNSSSNGVNR-------SSSYADVQDAESGGL-------LDADPWS---ADLSVPVPTASK-RL 636

  Fly   258 SAAAAPVVKPQTAEDELETVASMRLAYQELSMQKTREEAKLKTMDPAKAKQMERLGMGFNLRGSD 322
            ||..        ::..|:.:.|..:..:.:.....:|..:...:    ...|.....||:|....
Worm   637 SACG--------SDTNLDAIGSSSIDTKTVEWDSVKEACECGDL----LALMTAYAQGFDLNALH 689

  Fly   323 MAHSALGDMETIQQSAAPK------AKLSLLESE 350
            ...:||.......|:||.:      ||:::|:.:
Worm   690 NGTTALHIATRNGQTAAVEFLLLNGAKINMLDEK 723

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ArfGAP3	NP_001097664.2	ArfGap	17..121	CDD:214518	39/108 (36%)
cnt-1	NP_001369802.1	BAR_ACAPs	30..233	CDD:153287
		PH_ACAP	278..377	CDD:270070
		ArfGap_ACAP	447..565	CDD:350064	41/147 (28%)
		PTZ00322	628..>795	CDD:140343	18/109 (17%)
		ANK repeat	690..721	CDD:293786	7/30 (23%)
		Ank_2	695..775	CDD:403870	7/29 (24%)
		ANK repeat	723..754	CDD:293786	0/1 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910