DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ArfGAP3 and AGAP1

DIOPT Version :9

Sequence 1:	NP_001097664.2	Gene:	ArfGAP3 / 40487	FlyBaseID:	FBgn0037182	Length:	553	Species:	Drosophila melanogaster
Sequence 2:	XP_006712302.2	Gene:	AGAP1 / 116987	HGNCID:	16922	Length:	1151	Species:	Homo sapiens

Alignment Length:	163	Identity:	46/163 - (28%)
Similarity:	67/163 - (41%)	Gaps:	37/163 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 LRAQPANKSCFDCAAKAPTWSSVTYGIFICIDCSAVHRNLGVHLTFVRSTNLDTNWTWLQLRQMQ 84
            :|....|..|.||..:.|.|:|:..|..:||:||.:|||||.||:.|||.:|| :|....::.|.
Human   909 IRNMRGNSHCVDCETQNPNWASLNLGALMCIECSGIHRNLGTHLSRVRSLDLD-DWPVELIKVMS 972

  Fly    85 LGGNANAAQFFRAHNCSTTDAQV-------------KYNSR---------AAQLYRDKLCAQAQQ 127
            ..||..|...:...:...|...|             ||..:         ...|.:..|.|.|.:
Human   973 SIGNELANSVWEESSQGRTKPSVDSTREEKERWIRAKYEQKLFLAPLPCTELSLGQHLLRATADE 1037

  Fly   128 AMKT------HGTKLHLEQTDKSEGNEAAREED 154
            .::|      ||:        :.|.||...|.|
Human  1038 DLRTAILLLAHGS--------RDEVNETCGEGD 1062

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ArfGAP3	NP_001097664.2	ArfGap	17..121	CDD:214518	35/122 (29%)
AGAP1	XP_006712302.2	Centaurin_gamma	337..498	CDD:133303
		RAS	338..504	CDD:214541
		PH_AGAP	613..886	CDD:241281
		PH	616..>680	CDD:278594
		PH	<830..881	CDD:278594
		ArfGap	905..1019	CDD:279720	34/110 (31%)
		Ank_2	1030..1120	CDD:289560	11/41 (27%)
		ANK	1030..>1119	CDD:238125	11/41 (27%)
		ANK repeat	1062..1093	CDD:293786	1/1 (100%)
		ANK repeat	1095..1120	CDD:293786
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900