DRSC/TRiP Functional Genomics Resources

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Protein Alignment ArfGAP3 and AGAP2

DIOPT Version :9

Sequence 1:NP_001097664.2 Gene:ArfGAP3 / 40487 FlyBaseID:FBgn0037182 Length:553 Species:Drosophila melanogaster
Sequence 2:NP_001116244.1 Gene:AGAP2 / 116986 HGNCID:16921 Length:1192 Species:Homo sapiens


Alignment Length:56 Identity:29/56 - (51%)
Similarity:37/56 - (66%) Gaps:1/56 - (1%)


- Green bases have known domain annotations that are detailed below.


  Fly    20 LRAQPANKSCFDCAAKAPTWSSVTYGIFICIDCSAVHRNLGVHLTFVRSTNLDTNW 75
            :|....|..|.||.|..|||:|:..|..|||:||.:|||||.||:.|||.:|| :|
Human   937 IRNAKGNSICVDCGAPNPTWASLNLGALICIECSGIHRNLGTHLSRVRSLDLD-DW 991

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ArfGAP3NP_001097664.2 ArfGap 17..121 CDD:214518 29/56 (52%)
AGAP2NP_001116244.1 Interaction with EPB41L1. /evidence=ECO:0000250 1..23
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 24..377
Interactions with HOMER1 and NF2. /evidence=ECO:0000250 180..225
Interaction with PLCG1. /evidence=ECO:0000250 267..390
G domain 405..572
small_GTPase 405..572 CDD:197466
Centaurin_gamma 407..566 CDD:133303
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 582..619
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 634..673
PH_AGAP 674..914 CDD:241281
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 769..854
PH <845..909 CDD:278594
ArfGap 933..1047 CDD:279720 29/56 (52%)
Ank_2 1058..1148 CDD:289560
ANK 1058..>1147 CDD:238125
ANK repeat 1058..1088 CDD:293786
ANK repeat 1090..1121 CDD:293786
ANK 1 1090..1119
ANK 2 1123..1152
ANK repeat 1123..1148 CDD:293786
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1153..1192
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5347
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.900

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