DRSC/TRiP Functional Genomics Resources

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Protein Alignment ArfGAP3 and ACAP3

DIOPT Version :9

Sequence 1:NP_001097664.2 Gene:ArfGAP3 / 40487 FlyBaseID:FBgn0037182 Length:553 Species:Drosophila melanogaster
Sequence 2:XP_011538908.1 Gene:ACAP3 / 116983 HGNCID:16754 Length:844 Species:Homo sapiens


Alignment Length:334 Identity:85/334 - (25%)
Similarity:131/334 - (39%) Gaps:73/334 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 AGPSKQEI-------------ESVFSRLRAQPANKSCFDCAAKAPTWSSVTYGIFICIDCSAVHR 57
            |.||...|             |||..|:::...|..|.||....|.|:|:..|:.:||:||.:||
Human   392 ASPSTSSIDSATDTRERGVKGESVLQRVQSVAGNSQCGDCGQPDPRWASINLGVLLCIECSGIHR 456

  Fly    58 NLGVHLTFVRSTNLDTNWTWLQLRQMQLGGNANAAQFFRAH-----------NCSTTDAQV---- 107
            :||||.:.|||..|| :|....|:.|...||:...|.:.|.           :.|..|.:.    
Human   457 SLGVHCSKVRSLTLD-SWEPELLKLMCELGNSAVNQIYEAQCEGAGSRKPTASSSRQDKEAWIKD 520

  Fly   108 KYNSR-------------AAQLYRDKLCAQAQQAMK--THGTKLHLE------QTDKSEG--NEA 149
            ||..:             |.:.:|.:.|.:...:.:  |...|:.||      ....|.|  :..
Human   521 KYVEKKFLRKAPMAPALEAPRRWRVQKCLRPHSSPRAPTARRKVRLEPVLPCVAALSSVGTLDRK 585

  Fly   150 AREEDFFAQCDNEVD--FNVQNNNVSKQDPNPPTVAPVISVETQQGGAP--SVNLL----NSVVP 206
            .|.:..|  |.:|:|  |:..:...:...|..      :|.::..||:.  |.::|    .|||.
Human   586 FRRDSLF--CPDELDSLFSYFDAGAAGAGPRS------LSSDSGLGGSSDGSSDVLAFGSGSVVD 642

  Fly   207 AAVPSSIGARKVQPKKGGLGARKVGGLGATKVKTNFADIEA-RANAANEMKTSAAA---APVVKP 267
             :|....||...:......|..:....|...|:.....:.| ||..|.::...|||   ...|..
Human   643 -SVTEEEGAESEESSGEADGDTEAEAWGLADVRELHPGLLAHRAARARDLPALAAALAHGAEVNW 706

  Fly   268 QTAEDELET 276
            ..||||.:|
Human   707 ADAEDEGKT 715

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ArfGAP3NP_001097664.2 ArfGap 17..121 CDD:214518 37/131 (28%)
ACAP3XP_011538908.1 BAR 16..225 CDD:299863
PH 279..373 CDD:278594
PH_ACAP 281..377 CDD:270070
ArfGap 413..531 CDD:279720 38/118 (32%)
ANK 711..>798 CDD:238125 3/5 (60%)
ANK repeat 712..743 CDD:293786 2/4 (50%)
Ank_4 715..766 CDD:290365 1/1 (100%)
ANK repeat 745..776 CDD:293786
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5347
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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