DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ArfGAP3 and ADAP1

DIOPT Version :9

Sequence 1:	NP_001097664.2	Gene:	ArfGAP3 / 40487	FlyBaseID:	FBgn0037182	Length:	553	Species:	Drosophila melanogaster
Sequence 2:	NP_001271237.1	Gene:	ADAP1 / 11033	HGNCID:	16486	Length:	385	Species:	Homo sapiens

Alignment Length:	247	Identity:	54/247 - (21%)
Similarity:	88/247 - (35%)	Gaps:	58/247 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 VFSRLRA-QPANK------SCFDCA-------AKAPTWSSVTYGIFICIDCSAVHRNLGVHLTFV 66
            ||||:.. .||.:      ....||       .:.|.|:|.|.|:|||:.||.:|||: ..::.|
Human     5 VFSRVYCINPARRKWKEFEKMLGCAEEGHASLGRDPDWASYTLGVFICLSCSGIHRNI-PQVSKV 68

  Fly    67 RSTNLDTNWTWLQLRQMQLGGNANAAQFFRAHNCSTTDAQVKYNSRAAQLYRDKLCAQAQ----Q 127
            :|..||. |...|:..|...||              ..|:.::.|:....|.....:..|    |
Human    69 KSVRLDA-WEEAQVEFMASHGN--------------DAARARFESKVPSFYYRPTPSDCQLLREQ 118

  Fly   128 AMKTHGTKLHLEQTDKSEGNEAAREEDFFAQCDNEVDFNVQNNNVSKQDPNPPTVAPVISVETQQ 192
            .::....:......:|.|...|...|.|..:...:               |...::....:..::
Human   119 WIRAKYERQEFIYPEKQEPYSAGYREGFLWKRGRD---------------NGQFLSRKFVLTERE 168

  Fly   193 GGAPSVNLLNSVVPAAVPSSIGARKVQPKKGGLGARKVG---GLGATKVKTN 241
            |.....|..::..|.||      .|::.........|:|   ||..|.:|.|
Human   169 GALKYFNRNDAKEPKAV------MKIEHLNATFQPAKIGHPHGLQVTYLKDN 214

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ArfGAP3	NP_001097664.2	ArfGap	17..121	CDD:214518	32/117 (27%)
ADAP1	NP_001271237.1	ArfGap	28..137	CDD:214518	30/124 (24%)
		PH1_ADAP	141..249	CDD:270072	16/95 (17%)
		PH	142..239	CDD:278594	16/94 (17%)
		PH2_ADAP	263..368	CDD:241282
		PH	266..366	CDD:278594
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.900