DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ArfGAP3 and agap1

DIOPT Version :9

Sequence 1:	NP_001097664.2	Gene:	ArfGAP3 / 40487	FlyBaseID:	FBgn0037182	Length:	553	Species:	Drosophila melanogaster
Sequence 2:	XP_009300560.1	Gene:	agap1 / 100148154	ZFINID:	ZDB-GENE-130405-1	Length:	1255	Species:	Danio rerio

Alignment Length:	165	Identity:	54/165 - (32%)
Similarity:	78/165 - (47%)	Gaps:	36/165 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 SKQEIESVFSRLRAQP------------ANKSCFDCAAKAPTWSSVTYGIFICIDCSAVHRNLGV 61
            |||:     |||.:|.            .|..|.||.|:.|.|:|:..|..|||:||.:|||||.
Zfish   994 SKQK-----SRLSSQSEAIALQSVRNMRGNTRCVDCEAQNPDWASLNLGALICIECSGIHRNLGT 1053

  Fly    62 HLTFVRSTNLDTNWTWLQLRQMQLGGNANAAQFFRAHNCSTTDAQVKYNSRAAQLYRDK-LCAQA 125
            ||:.|||.:|| .|....::.|...||..|...:.|:    ...::|....|::..|:: :.|:.
Zfish  1054 HLSRVRSLDLD-EWPLELIKVMSAIGNELANSVWEAN----AQGRLKPAPDASREERERWIRAKY 1113

  Fly   126 QQAMKTHGTKLHLEQ---TDKSEGNE---AAREED 154
            :|       ||.|..   |:.|.|.:   |..|||
Zfish  1114 EQ-------KLFLASLTCTELSLGQQLLRATAEED 1141

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ArfGAP3	NP_001097664.2	ArfGap	17..121	CDD:214518	39/116 (34%)
agap1	XP_009300560.1	Centaurin_gamma	439..601	CDD:133303
		RAS	440..607	CDD:214541
		PH_AGAP	716..989	CDD:241281
		PH	719..>783	CDD:278594
		PH	<933..984	CDD:278594
		ArfGap	1008..1118	CDD:279720	38/121 (31%)
		Ank_2	1133..1223	CDD:289560	4/9 (44%)
		ANK	1133..>1222	CDD:238125	4/9 (44%)
		ANK repeat	1165..1196	CDD:293786
		ANK repeat	1198..1223	CDD:293786
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900