DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ArfGAP3 and zgc:162872

DIOPT Version :9

Sequence 1:	NP_001097664.2	Gene:	ArfGAP3 / 40487	FlyBaseID:	FBgn0037182	Length:	553	Species:	Drosophila melanogaster
Sequence 2:	XP_009290262.1	Gene:	zgc:162872 / 100004931	ZFINID:	ZDB-GENE-081022-1	Length:	701	Species:	Danio rerio

Alignment Length:	353	Identity:	77/353 - (21%)
Similarity:	129/353 - (36%)	Gaps:	102/353 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 NKSCFDCAAKAPTWSSVTYGIFICIDCSAVHRNLGVHLTFVRSTNLDTNWTWLQLRQMQLGGNAN 90
            |:.|.||....|.|:||..||.:||:||.:||:|||||:.|||..|| :|...||:.:.:.||..
Zfish   400 NQHCCDCGEAEPRWASVNLGITMCIECSGIHRSLGVHLSKVRSLTLD-SWEPEQLKLLCVLGNEV 463

  Fly    91 AAQFFRAHNCSTTDAQVKYNSRAAQLYRDKLCAQAQQAMKTHGTKLHLEQTDKSEGNEAAREEDF 155
            ....:..   ...|...|.::.:.:  :||......:.::......||:..|.......||:..:
Zfish   464 INGIYER---EAADGLQKPSAGSPR--QDKEQWIRSKYVEKRFVARHLDGPDADALKLRARKRLY 523

  Fly   156 FAQCDNEV-----------DFNVQNNNVSKQDPNPPTVAPVISVETQQGGAPSVNLLNSVVPAAV 209
            .|....::           :.|..||.                   |:|       ..:::.:|:
Zfish   524 SASVSGDLVAMAESLAEGAEINWNNNE-------------------QEG-------RTALIGSAI 562

  Fly   210 PSSIGARKVQPKKG-GLGARKVGGLGATKVKTNFAD-------IEARAN--AANEMKTSAAAAPV 264
            ..|:.|.:...:.| .:..|...|.||......:..       ::..||  ||:|......:..:
Zfish   563 GGSLLACEFLLQNGANVNHRDQRGQGALHAAATYGHTGQVCLLLKRGANQYAADEKGNDPLSIAI 627

  Fly   265 VKPQTAEDELETVASMRLAYQELSMQKTREEAKLKTMDPAKAKQMERLGMGFNLRGSDMAHSALG 329
               :||..::.|:         |.|.:..||                      :|.|:....::|
Zfish   628 ---ETAHADIVTL---------LRMARMNEE----------------------MRDSEGFFGSVG 658

  Fly   330 DMETIQQSAAPKAKLSLLESENFFTDFS 357
            |.||.|               :.|.|||
Zfish   659 DDETFQ---------------DIFRDFS 671

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ArfGAP3	NP_001097664.2	ArfGap	17..121	CDD:214518	34/94 (36%)
zgc:162872	XP_009290262.1	BAR_ACAPs	18..217	CDD:153287
		PH	265..357	CDD:278594
		PH_ACAP	266..362	CDD:270070
		ArfGap	399..504	CDD:279720	35/109 (32%)
		Ank_2	<508..583	CDD:289560	13/100 (13%)
		ANK	522..638	CDD:238125	22/153 (14%)
		ANK repeat	552..583	CDD:293786	5/37 (14%)
		Ank_2	557..649	CDD:289560	20/125 (16%)
		ANK repeat	585..616	CDD:293786	6/30 (20%)
		ANK repeat	618..649	CDD:293786	7/64 (11%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900