DRSC/TRiP Functional Genomics Resources

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Protein Alignment LTA4H and CG10602

DIOPT Version :9

Sequence 1:NP_000886.1 Gene:LTA4H / 4048 HGNCID:6710 Length:611 Species:Homo sapiens
Sequence 2:NP_609916.5 Gene:CG10602 / 35146 FlyBaseID:FBgn0032721 Length:684 Species:Drosophila melanogaster


Alignment Length:616 Identity:274/616 - (44%)
Similarity:385/616 - (62%) Gaps:22/616 - (3%)


- Green bases have known domain annotations that are detailed below.


Human     4 IVDTCSLASPASVCRTKHLHLRCSVDFTRRTLTGTAALTVQSQEDNLRSLVLDTKDLTIEKVVI- 67
            :||..|.:.| .:..|:|..|...:||....:.|:.....:....||..::||.:|:.:....: 
  Fly    77 VVDPSSYSQP-DLITTEHSALNWKIDFAATKIQGSVLHRFKVLTANLDKILLDVRDINVTNATLL 140

Human    68 -NGQE--VKYALGERQSYKGSPMEISLPIALSKNQEIVIEISFETSPKSSALQWLTPEQTSGKEH 129
             .|.|  :.:.:.:.....|..:.:.||...:|. .:.:.|.:|||..:|.||||.|.||.||||
  Fly   141 AGGSELPINFFISDAVDDIGQKLTLELPSGTAKG-SLNVRIDYETSSSASGLQWLNPTQTLGKEH 204

Human   130 PYLFSQCQAIHCRAILPCQDTPSVKLTYTAEVSVPKELVALMSAIRDGETPDPEDPSRKIYKFIQ 194
            ||:||||||||.|:::||||||:||.||.|.|..|.||.|||||:     .|.::|.:.::|  |
  Fly   205 PYMFSQCQAIHARSVIPCQDTPAVKFTYDATVEHPSELTALMSAL-----IDKKEPGKTLFK--Q 262

Human   195 KVPIPCYLIALVVGALESRQIGPRTLVWSEKEQVEKSAYEFSETESMLKIAEDLGGPYVWGQYDL 259
            :||||.||:|:.:|.|.||.:|..:.||:|:..|:..|.|||||.:|||.|.:|.|||||.||||
  Fly   263 EVPIPAYLVAIAIGKLVSRPLGENSSVWAEEAIVDACAEEFSETATMLKTATELCGPYVWKQYDL 327

Human   260 LVLPPSFPYGGMENPCLTFVTPTLLAGDKSLSNVIAHEISHSWTGNLVTNKTWDHFWLNEGHTVY 324
            ||:|||||:||||||||||||||||||||||::|:||||:|||||||||||.::|||||||.||:
  Fly   328 LVMPPSFPFGGMENPCLTFVTPTLLAGDKSLADVVAHEIAHSWTGNLVTNKNFEHFWLNEGFTVF 392

Human   325 LERHICGRLFGEKFRHFNALGGWGELQNSVKT-FGETHPFTKLVVDLTDIDPDVAYSSVPYEKGF 388
            :|..|.||:.|.|...|..|....:||..::| ..:|...|||||||::..||.|:|||||.||.
  Fly   393 VESKIVGRMQGAKELDFKMLSNLTDLQECIRTQLNKTPELTKLVVDLSNCGPDDAFSSVPYIKGS 457

Human   389 ALLFYLEQLLGGPEIFLGFLKAYVEKFSYKSITTDDWKDFLYSYF--KDKVDVLNQVDWNAWLYS 451
            ..|.|||.|.|||.:|..||:.|::|::||||.|.|::..||.||  .||.|.|:.|||:.||.|
  Fly   458 TFLRYLEDLFGGPTVFEPFLRDYLKKYAYKSIETKDFQSALYDYFIDTDKKDKLSAVDWDLWLKS 522

Human   452 PGLPPIKPNYDMTLTNACIALSQRWITAKEDDLNSFNATDLK-DLSSHQLNEFLAQTLQR---AP 512
            .|:||:.||:|.:|.|....|:..|.:....:|  .::.::| .:|.|||.:||.:.::.   ..
  Fly   523 EGMPPVIPNFDESLANVTKELASLWSSKSVAEL--ADSAEIKTTISIHQLIDFLGKLIESKDIVD 585

Human   513 LPLGHIKRMQEVYNFNAINNSEIRFRWLRLCIQSKWEDAIPLALKMATEQGRMKFTRPLFKDLAA 577
            |..|.|..::..||..:..|:|:|||..||.|:::....:...|:.|....||||.||:::|||.
  Fly   586 LNEGKINLLESTYNLKSSKNAEVRFRLNRLIIRARLIKRLDEILEFANSNFRMKFCRPIYRDLAG 650

Human   578 FDKSHDQAVRTYQEHKASMHPVTAMLVGKDL 608
            :.::...|:|.:...|..|..|.:..:.|||
  Fly   651 WPEAKPAAIRNFVNVKDQMMAVCSHTIEKDL 681

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LTA4HNP_000886.1 leuko_A4_hydro 6..608 CDD:274120 271/612 (44%)
Substrate binding. /evidence=ECO:0000269|PubMed:18804029 135..137 1/1 (100%)
Substrate binding. /evidence=ECO:0000269|PubMed:18804029 267..272 3/4 (75%)
Inhibitor ARM1 binding. /evidence=ECO:0000269|PubMed:24591641 362..365 0/2 (0%)
Substrate binding. /evidence=ECO:0000269|PubMed:18804029 564..566 1/1 (100%)
CG10602NP_609916.5 Ribosomal_L13 16..>50 CDD:294238
leuko_A4_hydro 79..681 CDD:274120 271/612 (44%)
M1_LTA4H 79..520 CDD:189006 220/449 (49%)
Leuk-A4-hydro_C 541..680 CDD:286244 39/140 (28%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165147923
Domainoid 1 1.000 243 1.000 Domainoid score I2225
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H6820
Inparanoid 1 1.050 511 1.000 Inparanoid score I1322
Isobase 1 0.950 - 0 Normalized mean entropy S1006
OMA 1 1.010 - - QHG54868
OrthoDB 1 1.010 - - D306356at33208
OrthoFinder 1 1.000 - - FOG0003813
OrthoInspector 1 1.000 - - oto90123
orthoMCL 1 0.900 - - OOG6_101703
Panther 1 1.100 - - LDO PTHR45726
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R661
SonicParanoid 1 1.000 - - X2657
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
1514.890

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