DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Trxr-2 and GLR1

DIOPT Version :9

Sequence 1:	NP_524216.1	Gene:	Trxr-2 / 40475	FlyBaseID:	FBgn0037170	Length:	516	Species:	Drosophila melanogaster
Sequence 2:	NP_015234.1	Gene:	GLR1 / 856014	SGDID:	S000006012	Length:	483	Species:	Saccharomyces cerevisiae

Alignment Length:	517	Identity:	174/517 - (33%)
Similarity:	270/517 - (52%)	Gaps:	63/517 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 SSTHNALRSSLGWCRLAASRPRYDYDLVVLGGGSAGLACAKEAAGCGARVLCFDYVKPTPVGTKW 73
            |:|....| ||....::.:...|||  :|:||||.|:|.|:.||..||:.|.        |..|
Yeast     3 SATKQTFR-SLQIRTMSTNTKHYDY--LVIGGGSGGVASARRAASYGAKTLL--------VEAK- 55

  Fly    74 GIGGTCVNVGCIPKKLMHQASLLGEAVHEAVAYG----WNVDDTNIRPDWRKLVRSVQNHIKSVN 134
            .:|||||||||:|||:|..||.|...|..|..||    ..:|..::..:|.:..:....::..:|
Yeast    56 ALGGTCVNVGCVPKKVMWYASDLATRVSHANEYGLYQNLPLDKEHLTFNWPEFKQKRDAYVHRLN 120

  Fly   135 WVTRVDLRDKKVEYVNSMATFRDSHTIEYVAMPGAEHRQVTSE-----YVVVAVGGRPRYPD-IP 193
            .:.:.:|..:||:.|...|.|.....:|      .:.|..|:|     :::||.||:..:|: ||
Yeast   121 GIYQKNLEKEKVDVVFGWARFNKDGNVE------VQKRDNTTEVYSANHILVATGGKAIFPENIP 179

  Fly   194 GAVELGITSDDIFSYEREPGRTLVVGAGYVGLECACFLKGLGYEPTVMVR-SIVLRGFDRQMSEL 257
            | .|||..||..|..|.:|.:.:||||||:|:|.|....|||.|..:::| ..|||.||..:...
Yeast   180 G-FELGTDSDGFFRLEEQPKKVVVVGAGYIGIELAGVFHGLGSETHLVIRGETVLRKFDECIQNT 243

  Fly   258 LAAMMTERGIPFLGTTIPKAVERQADGRLLVRYRNTTTQMDGSDVFDTVLWAIGRKGLIEDLNLD 322
            :.....:.||.....:....||:..:...|..:.|.:..:|  || |.::|.||||..: .:..:
Yeast   244 ITDHYVKEGINVHKLSKIVKVEKNVETDKLKIHMNDSKSID--DV-DELIWTIGRKSHL-GMGSE 304

  Fly   323 AAGVKTHD-DKIVVDAAEATSVPHIFAVGDIIYGRPELTPVAILSGRLLARRLFAGS---TQLMD 383
            ..|:|.:. |:|:.|..:.|:||:|:::||:: |:.|||||||.:||.|:.|||...   ...:|
Yeast   305 NVGIKLNSHDQIIADEYQNTNVPNIYSLGDVV-GKVELTPVAIAAGRKLSNRLFGPEKFRNDKLD 368

  Fly   384 YADVATTVFTPLEYSCVGMSEETAIELRGADNIEVFHG-----YY------KPTEFFIPQKSVRH 437
            |.:|.:.:|:..|...:|:||:.|||..|.:||:|::.     ||      .||.:
Yeast   369 YENVPSVIFSHPEAGSIGISEKEAIEKYGKENIKVYNSKFTAMYYAMLSEKSPTRY--------- 424

  Fly   438 CYLKAVAEVSGDQKILGLHYIGPVAGEVIQGFAAALKTGLTVKTLLNTVGIHPTTAEEFTRL 499
               |.|. ...::|::|||.:|..:.|::|||..|:|.|.|.....|.|.||||:|||...:
Yeast   425 ---KIVC-AGPNEKVVGLHIVGDSSAEILQGFGVAIKMGATKADFDNCVAIHPTSAEELVTM 482

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Trxr-2	NP_524216.1	NADB_Rossmann	29..>68	CDD:304358	16/38 (42%)
		TGR	31..515	CDD:273624	169/495 (34%)
		NADB_Rossmann	<144..239	CDD:304358	38/100 (38%)
		Pyr_redox	214..288	CDD:278498	23/74 (31%)
		Pyr_redox_dim	388..497	CDD:280934	40/119 (34%)
GLR1	NP_015234.1	gluta_reduc_1	22..483	CDD:273614	169/497 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	175	1.000	Domainoid score	I738
eggNOG	1	0.900	-	-		E1_COG1249
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	253	1.000	Inparanoid score	I652
Isobase	1	0.950	-	0	Normalized mean entropy	S706
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000578
OrthoInspector	1	1.000	-	-		otm46525
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R529
SonicParanoid	1	1.000	-	-		X1089
TreeFam	0	0.000	Not matched by this tool.
	9	8.840