DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Trxr-2 and GR

DIOPT Version :9

Sequence 1:	NP_524216.1	Gene:	Trxr-2 / 40475	FlyBaseID:	FBgn0037170	Length:	516	Species:	Drosophila melanogaster
Sequence 2:	NP_191026.1	Gene:	GR / 824631	AraportID:	AT3G54660	Length:	565	Species:	Arabidopsis thaliana

Alignment Length:	508	Identity:	169/508 - (33%)
Similarity:	249/508 - (49%)	Gaps:	43/508 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 SSTHNALRSSLGWCRLAASRPRYDYDLVVLGGGSAGLACAKEAAGCGARV----LCFDYVKPTPV 69
            :||.|.          |.|...||:||..:|.||.|:..::.|...||..    |.|..:.....
plant    74 ASTDNG----------AESDRHYDFDLFTIGAGSGGVRASRFATSFGASAAVCELPFSTISSDTA 128

  Fly    70 GTKWGIGGTCVNVGCIPKKLMHQASLLGEAVHEAVAYGWNVDDTNIRPDWRKLVRSVQNHIKSVN 134
            |   |:|||||..||:||||:..||.......::..:||.. :|....||..|:.:....::.:.
plant   129 G---GVGGTCVLRGCVPKKLLVYASKYSHEFEDSHGFGWKY-ETEPSHDWTTLIANKNAELQRLT 189

  Fly   135 WVTRVDLRDKKVEYVNSMATFRDSHTIEYVAMPGAEHRQVTSEYVVVAVGGRPRYPDIPGAVELG 199
            .:.:..|....|:.:.......|.||::      .:.:..|:..:::||||||..|||||. |..
plant   190 GIYKNILSKANVKLIEGRGKVIDPHTVD------VDGKIYTTRNILIAVGGRPFIPDIPGK-EFA 247

  Fly   200 ITSDDIFSYEREPGRTLVVGAGYVGLECACFLKGLGYEPTVMVR-SIVLRGFDRQMSELLAAMMT 263
            |.||.......:|.:..:||.||:.||.|....||..|..|.:| ..||||||..:.:.:...|:
plant   248 IDSDAALDLPSKPKKIAIVGGGYIALEFAGIFNGLNCEVHVFIRQKKVLRGFDEDVRDFVGEQMS 312

  Fly   264 ERGIPFLGTTIPKAVERQADGRLLVRYRNTTTQMDGSDVFDTVLWAIGRKGLIEDLNLDAAGVK- 327
            .|||.|.....|:|:.:..||...::....|  ::|   |..|::|.|||...::|.|:..|||
plant   313 LRGIEFHTEESPEAIIKAGDGSFSLKTSKGT--VEG---FSHVMFATGRKPNTKNLGLENVGVKM 372

  Fly   328 THDDKIVVDAAEATSVPHIFAVGDIIYGRPELTPVAILSGRLLARRLFAGSTQLMDYADVATTVF 392
            ..:..|.||....||||.|:||||:. .|..|||||::.|..||:.||.......||..|...||
plant   373 AKNGAIEVDEYSQTSVPSIWAVGDVT-DRINLTPVALMEGGALAKTLFQNEPTKPDYRAVPCAVF 436

  Fly   393 TPLEYSCVGMSEETAIELRGADNIEVFHGYYKP---TEFFIPQKSVRHCYLKAVAEVSGDQKILG 454
            :......||::||.|||..|  :::|:...::|   |...:|.:    .::|.:. .:...|:||
plant   437 SQPPIGTVGLTEEQAIEQYG--DVDVYTSNFRPLKATLSGLPDR----VFMKLIV-CANTNKVLG 494

  Fly   455 LHYIGPVAGEVIQGFAAALKTGLTVKTLLNTVGIHPTTAEEFTRLSITKRSGR 507
            :|..|..:.|:||||..|:|.|||......|||:|||.||||..:....|..|
plant   495 VHMCGEDSPEIIQGFGVAVKAGLTKADFDATVGVHPTAAEEFVTMRAPTRKFR 547

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Trxr-2	NP_524216.1	NADB_Rossmann	29..>68	CDD:304358	13/42 (31%)
		TGR	31..515	CDD:273624	164/486 (34%)
		NADB_Rossmann	<144..239	CDD:304358	31/94 (33%)
		Pyr_redox	214..288	CDD:278498	27/74 (36%)
		Pyr_redox_dim	388..497	CDD:280934	39/111 (35%)
GR	NP_191026.1	PLN02546	1..565	CDD:215301	169/508 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	187	1.000	Domainoid score	I973
eggNOG	1	0.900	-	-		E1_COG1249
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	264	1.000	Inparanoid score	I952
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D581771at2759
OrthoFinder	1	1.000	-	-		FOG0000578
OrthoInspector	1	1.000	-	-		mtm1060
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR48105
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1089
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.970