DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Trxr-2 and LPD1

DIOPT Version :9

Sequence 1:	NP_524216.1	Gene:	Trxr-2 / 40475	FlyBaseID:	FBgn0037170	Length:	516	Species:	Drosophila melanogaster
Sequence 2:	NP_001078165.1	Gene:	LPD1 / 820951	AraportID:	AT3G16950	Length:	623	Species:	Arabidopsis thaliana

Alignment Length:	559	Identity:	139/559 - (24%)
Similarity:	226/559 - (40%)	Gaps:	109/559 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 IKFL--RSSTHNALRSSLGWCRLAASRPRYDYDLVVLGGGSAGLACAKEAAGCGARVLCFDYVKP 66
            |:||  :|...:|..||.|   ..|....:||||:::|.|..|...|..|...|.:....:
plant    59 IQFLSRKSFQVSASASSNG---NGAPPKSFDYDLIIIGAGVGGHGAALHAVEKGLKTAIIE---- 116

  Fly    67 TPVGTKWG--IGGTCVNVGCIPKKLMHQAS-----LLGEAVHEAVAYGWNV-----DDTNIRPDW 119
                   |  :||||||.||:|.|.:...|     |..|  |...::|..|     |...:....
plant   117 -------GDVVGGTCVNRGCVPSKALLAVSGRMRELQNE--HHMKSFGLQVSAAGYDRQGVADHA 172

  Fly   120 RKLVRSVQNHIKSVNWVTRVD--------LRDKKVEYVNSMATFRDSHTIEYVAMPGAEHRQVTS 176
            ..|...::|::.:......||        |..:||:|                    .:...:|:
plant   173 NNLATKIRNNLTNSMKAIGVDILTGFGSVLGPQKVKY--------------------GKDNIITA 217

  Fly   177 EYVVVAVGGRPRYPDIPGAVELG----ITSDDIFSYEREPGRTLVVGAGYVGLECACFLKGLGYE 237
            :.:::|.|.   .|.:|..:|:.    ||||.....|..|....:||:||:|||.:.....||.|
plant   218 KDIIIATGS---VPFVPKGIEVDGKTVITSDHALKLESVPEWIAIVGSGYIGLEFSDVYTALGSE 279

  Fly   238 PT-VMVRSIVLRGFDRQMSELL-AAMMTERGIPFLGTTIPKAVERQADGR-LLVRYRNTTTQ--M 297
            .| :.....::.|||.::|:|. ..::..|.|.:........:....||: :|:...:..|:  .
plant   280 VTFIEALDQLMPGFDPEISKLAQRVLINPRKIDYHTGVFASKITPARDGKPVLIELIDAKTKEPK 344

  Fly   298 DGSDVFDTVLWAIGRKGLIEDLNLDAAGVKTH------DDKIVVDAAEATSVPHIFAVGDIIYGR 356
            |..:| |..|.|.||......|.|:...|.|.      |:::.|...:.|.||:::.:|| ..|:
plant   345 DTLEV-DAALIATGRAPFTNGLGLENVNVVTQRGFIPVDERMRVIDGKGTLVPNLYCIGD-ANGK 407

  Fly   357 PELTPVAILSGRLLARRLFAGSTQLMDYADVATTVFTPLEYSCVGMSEETAIELRGADNIEVFHG 421
            ..|...|...|..:..:: :|...::::..:....||..|.|.||::|..|.| :|..  |.|..
plant   408 LMLAHAASAQGISVVEQV-SGRDHVLNHLSIPAACFTHPEISMVGLTEPQAKE-KGEK--EGFKV 468

  Fly   422 YYKPTEFFIPQKSVRHCYLKAVAEVSGD-----------QKILGLHYIGPVAGEVIQGFAAALKT 475
            ....|.|        ....||:||..|:           .:|||:|..|..|.::|...:.|:..
plant   469 SVVKTSF--------KANTKALAENEGEGIAKMIYRPDNGEILGVHIFGLHAADLIHEASNAIAL 525

  Fly   476 GLTVKTLLNTVGIHPTTAEEFTRL--------SITKRSG 506
            |..::.:...|..|||.:|....|        ..|.|:|
plant   526 GTRIQDIKLAVHAHPTLSEVLDELFKAAKVESHATTRTG 564

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Trxr-2	NP_524216.1	NADB_Rossmann	29..>68	CDD:304358	10/38 (26%)
		TGR	31..515	CDD:273624	130/530 (25%)
		NADB_Rossmann	<144..239	CDD:304358	25/98 (26%)
		Pyr_redox	214..288	CDD:278498	20/76 (26%)
		Pyr_redox_dim	388..497	CDD:280934	33/119 (28%)
LPD1	NP_001078165.1	PRK06416	103..553	CDD:235798	119/499 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1249
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D581771at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820