DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Trxr-2 and txnrd3

DIOPT Version :9

Sequence 1:	NP_524216.1	Gene:	Trxr-2 / 40475	FlyBaseID:	FBgn0037170	Length:	516	Species:	Drosophila melanogaster
Sequence 2:	NP_001340296.1	Gene:	txnrd3 / 779989	XenbaseID:	XB-GENE-973837	Length:	598	Species:	Xenopus tropicalis

Alignment Length:	515	Identity:	247/515 - (47%)
Similarity:	332/515 - (64%)	Gaps:	12/515 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 KFLRSSTHNALRSSLGWCRLAASRPRYDYDLVVLGGGSAGLACAKEAAGCGARVLCFDYVKPTPV 69
            |.|::....:|...||     .:...|||||:|:||||.||||:||||..|.:|:..|||.|||.
Frog    89 KTLKAHKDGSLAKLLG-----DNSVTYDYDLIVIGGGSGGLACSKEAASFGKKVMVLDYVVPTPK 148

  Fly    70 GTKWGIGGTCVNVGCIPKKLMHQASLLGEAVHEAVAYGWNVDDTNIRPDWRKLVRSVQNHIKSVN 134
            ||.||:||||||||||||||||||::||:::.::..:||..:: .::.:|..:..::||:|.|:|
Frog   149 GTSWGLGGTCVNVGCIPKKLMHQAAILGQSLKDSRKFGWEYEE-QVKHNWDTMREAIQNYIGSLN 212

  Fly   135 WVTRVDLRDKKVEYVNSMATFRDSHTIEYVAMPGAEHRQVTSEYVVVAVGGRPRYPDIPGAVELG 199
            |..||.||||:|.|.|:...|.:.|.|:.....|.| ...|:|..|||.|.||||.:|||..|..
Frog   213 WGYRVSLRDKQVRYENAYGEFVEPHKIKATNKRGKE-SFFTAEKFVVATGERPRYLNIPGDKEYC 276

  Fly   200 ITSDDIFSYEREPGRTLVVGAGYVGLECACFLKGLGYEPTVMVRSIVLRGFDRQMSELLAAMMTE 264
            |||||:||....||:||||||.||.||||.||.|||.:.|||||||:|||||::|:....|.|..
Frog   277 ITSDDLFSLPYCPGKTLVVGASYVALECAGFLAGLGLDATVMVRSILLRGFDQEMANRAGAYMET 341

  Fly   265 RGIPFLGTTIPKAV---ERQADGRLLVRYRNTTTQMDGSDVFDTVLWAIGRKGLIEDLNLDAAGV 326
            .|:.|:...:|.:|   |....|||.|..:.|.......|.::|||.|:||.....::.|:..||
Frog   342 HGVKFIKQFVPISVELLEEGTPGRLKVTAKATEGDQIIEDEYNTVLIAVGRDACTRNIGLEKIGV 406

  Fly   327 KTHD--DKIVVDAAEATSVPHIFAVGDIIYGRPELTPVAILSGRLLARRLFAGSTQLMDYADVAT 389
            |.::  .||.|...|.||||:::|:|||:.|:.|||||||.:||||||||:.||....||.:|.|
Frog   407 KVNERNGKIPVSDEEQTSVPYVYAIGDILDGKLELTPVAIQAGRLLARRLYKGSKLKCDYVNVPT 471

  Fly   390 TVFTPLEYSCVGMSEETAIELRGADNIEVFHGYYKPTEFFIPQKSVRHCYLKAVAEVSGDQKILG 454
            ||||||||.|.|.:||.|||:.|.:|:||:|..:.|.|:.:|.:....|:.|.:.....|.:::|
Frog   472 TVFTPLEYGCCGYAEEKAIEIYGEENLEVYHTLFWPLEWTVPSRDNNTCFAKIICNKQDDDRVVG 536

  Fly   455 LHYIGPVAGEVIQGFAAALKTGLTVKTLLNTVGIHPTTAEEFTRLSITKRSGRDPTPASC 514
            .|.:||.|||:.|||.||:|.|||.:.|..|:|||||.||.||.:.::|.||.|.|...|
Frog   537 FHVLGPNAGEITQGFGAAIKCGLTKEKLDETIGIHPTCAEVFTTMDVSKSSGGDITQKGC 596

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Trxr-2	NP_524216.1	NADB_Rossmann	29..>68	CDD:304358	24/38 (63%)
		TGR	31..515	CDD:273624	242/489 (49%)
		NADB_Rossmann	<144..239	CDD:304358	49/94 (52%)
		Pyr_redox	214..288	CDD:278498	40/76 (53%)
		Pyr_redox_dim	388..497	CDD:280934	52/108 (48%)
txnrd3	NP_001340296.1	GRX_GRXh_1_2_like	21..102	CDD:239511	3/12 (25%)
txnrd3	NP_001340296.1	TGR	110..598	CDD:273624	242/489 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D164705at33208
OrthoFinder	1	1.000	-	-		FOG0000578
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010