DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Trxr-2 and CG7430

DIOPT Version :9

Sequence 1:	NP_524216.1	Gene:	Trxr-2 / 40475	FlyBaseID:	FBgn0037170	Length:	516	Species:	Drosophila melanogaster
Sequence 2:	NP_001262000.1	Gene:	CG7430 / 39988	FlyBaseID:	FBgn0036762	Length:	504	Species:	Drosophila melanogaster

Alignment Length:	515	Identity:	141/515 - (27%)
Similarity:	232/515 - (45%)	Gaps:	63/515 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 SSTHNALRSSLGWCRLAASRPRYDYDLVVLGGGSAGLACAKEAAGCGARVLCFDYVKPTPVGTKW 73
            ||||.|                   |:||:|.|..|...|.:||..|        :|...|..:.
  Fly    33 SSTHEA-------------------DIVVIGSGPGGYVAAIKAAQMG--------MKTVSVEKEA 70

  Fly    74 GIGGTCVNVGCIPKKLMHQASLLGEAVHEAVAYGWNVDDT-----NIRPDWRKLVRSVQNHIKSV 133
            .:||||:||||||.|     :||..:.:..:|:..:::..     ::..|..||:....|.:|::
  Fly    71 TLGGTCLNVGCIPSK-----ALLNNSHYYHMAHSGDLEKRGISCGSVSLDLEKLMGQKSNAVKAL 130

  Fly   134 NWVTRVDLRDKKVEYVNSMATFRDSHTIEYVAMPGAEHRQVTSEYVVVAVGGR-PRYPDIPGAVE 197
            .....:..:..||..:....|..:.:.:|.....|:. ..|.::.:::|.|.. ..:|.|....|
  Fly   131 TGGIAMLFKKNKVTQLTGFGTIVNPNEVEVKKSDGST-ETVKTKNILIATGSEVTPFPGIEIDEE 194

  Fly   198 LGITSDDIFSYEREPGRTLVVGAGYVGLECACFLKGLGYEPTVM--VRSIVLRGFDRQMSELLAA 260
            :.::|.......:.|...:|:|||.:|||.......||.|.|.:  :.:|...|.|.::|:....
  Fly   195 VIVSSTGALKLAKVPKHLVVIGAGVIGLELGSVWSRLGAEVTAIEFMDTIGGVGIDNEVSKTFQK 259

  Fly   261 MMTERGIPF-LGTTIPKAVERQADGRLLVRYRNTTTQMDGSDVFDTVLWAIGRKGLIEDLNLDAA 324
            ::|::|:.| |||.: .|..|..| .:.|...|..:........|.:|.::||:...|.|.|:|.
  Fly   260 VLTKQGLKFKLGTKV-TAASRSGD-NVTVSVENAKSGEKEEIQCDALLVSVGRRPYTEGLGLEAV 322

  Fly   325 G-VKTHDDKIVVDAAEATSVPHIFAVGDIIYGRPELTPVAILSGRLLARRLFAGSTQLMDYADVA 388
            | ||....:|.|:|...|.||:|:|:||.|:| |.|...|...|.:....:..|...: ||..|.
  Fly   323 GIVKDDRGRIPVNATFQTVVPNIYAIGDCIHG-PMLAHKAEDEGLITIEGINGGHVHI-DYNCVP 385

  Fly   389 TTVFTPLEYSCVGMSEETAIELRGADNIEVFHGYYKPTEF-FIPQKSVR-----HCYLKAVAEVS 447
            :.|:|..|.:.||.||| .::..|.        .||..:| |:.....:     ..::|.:|:.:
  Fly   386 SVVYTHPEVAWVGKSEE-QLKQEGV--------AYKVGKFPFLANSRAKTNNDTDGFVKVLADQA 441

  Fly   448 GDQKILGLHYIGPVAGEVIQGFAAALKTGLTVKTLLNTVGIHPTTAEEFTRLSITKRSGR 507
            .| ||||.|.|||.|||:|.....|::.|...:.:......|||.:|.....::....|:
  Fly   442 TD-KILGTHIIGPGAGELINEAVLAMEYGAAAEDVARVCHAHPTCSEALREANVAAAFGK 500

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Trxr-2	NP_524216.1	NADB_Rossmann	29..>68	CDD:304358	11/38 (29%)
		TGR	31..515	CDD:273624	136/493 (28%)
		NADB_Rossmann	<144..239	CDD:304358	23/95 (24%)
		Pyr_redox	214..288	CDD:278498	24/76 (32%)
		Pyr_redox_dim	388..497	CDD:280934	34/114 (30%)
CG7430	NP_001262000.1	PRK06327	35..504	CDD:235779	139/513 (27%)
		NADB_Rossmann	35..>74	CDD:304358	15/65 (23%)
		Pyr_redox	211..290	CDD:278498	25/80 (31%)
		Pyr_redox_dim	385..491	CDD:280934	34/115 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45464302
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1249
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D38341at50557
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.750