DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Trxr-2 and Dld

DIOPT Version :9

Sequence 1:	NP_524216.1	Gene:	Trxr-2 / 40475	FlyBaseID:	FBgn0037170	Length:	516	Species:	Drosophila melanogaster
Sequence 2:	NP_955417.1	Gene:	Dld / 298942	RGDID:	735073	Length:	509	Species:	Rattus norvegicus

Alignment Length:	492	Identity:	120/492 - (24%)
Similarity:	228/492 - (46%)	Gaps:	43/492 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 DYDLVVLGGGSAGLACAKEAAGCGARVLCFDYVKPTPVGTKWGIGGTCVNVGCIPKKLMHQASLL 96
            |.|:.|:|.|..|...|.:||..|.:.:|.:..:.        :||||:||||||.|     :||
  Rat    41 DADVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNET--------LGGTCLNVGCIPSK-----ALL 92

  Fly    97 GEAVHEAVAYGWN-----VDDTNIRPDWRKLVRSVQNHIKSVNWVTRVDLRDKKVEYVNSMATFR 156
            ..:.:..:|:|.:     ::...:|.:..|::...::.:|::........:..||.:||......
  Rat    93 NNSHYYHLAHGKDFASRGIEIPEVRLNLEKMMEQKRSAVKALTGGIAHLFKQNKVVHVNGFGKIT 157

  Fly   157 DSHTIEYVAMPGAEHRQVTSEYVVVAVGGR-PRYPDIPGAVELGITSDDIFSYEREPGRTLVVGA 220
            ..:.:......|:. :.:.::.:::|.|.. ..:|.|....:..::|....|.::.|.:.:|:||
  Rat   158 GKNQVTATTADGST-QVIGTKNILIATGSEVTPFPGITIDEDTIVSSTGALSLKKVPEKLVVIGA 221

  Fly   221 GYVGLECACFLKGLGYEPTVM-----VRSIVLRGFDRQMSELLAAMMTERGIPFLGTTIPKAVER 280
            |.:|:|.....:.||.:.|.:     |..|   |.|.::|:....::.::|..|...|......:
  Rat   222 GVIGVELGSVWQRLGADVTAVEFLGHVGGI---GIDMEISKNFQRILQKQGFKFKLNTKVTGATK 283

  Fly   281 QADGRLLVRYRNTTTQMDGSDVFDTVLWAIGRKGLIEDLNLDAAGVKTHDDK--IVVDAAEATSV 343
            ::||::.|.....:.........|.:|..|||:...::|.|:..|::. |.|  |.|:....|.:
  Rat   284 KSDGKIDVSVEAASGGKAEVITCDVLLVCIGRRPFTQNLGLEELGIEL-DPKGRIPVNTRFQTKI 347

  Fly   344 PHIFAVGDIIYGRPELTPVAILSGRLLARRLFAGSTQLMDYADVATTVFTPLEYSCVGMSEETAI 408
            |:|||:||::.| |.|...|...|.:....:..|:..: ||..|.:.::|..|.:.||.|||...
  Rat   348 PNIFAIGDVVAG-PMLAHKAEDEGIICVEGMAGGAVHI-DYNCVPSVIYTHPEVAWVGKSEEQLK 410

  Fly   409 ELRGADNIEVFHGYYKPTEFFIPQKSVRHCYLKAVAEVSGDQ---KILGLHYIGPVAGEVIQGFA 470
            |    :.:|...|.:   .|....::..:.....:.::.|.:   :|||.|.:||.|||::...|
  Rat   411 E----EGVEFKVGKF---PFAANSRAKTNADTDGMVKILGHKSTDRILGAHILGPGAGEMVNEAA 468

  Fly   471 AALKTGLTVKTLLNTVGIHPTTAEEFTRLSITKRSGR 507
            .||:.|.:.:.:......|||.:|.|...::....|:
  Rat   469 LALEYGASCEDVARVCHAHPTLSEAFREANLAASFGK 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Trxr-2	NP_524216.1	NADB_Rossmann	29..>68	CDD:304358	11/35 (31%)
		TGR	31..515	CDD:273624	120/492 (24%)
		NADB_Rossmann	<144..239	CDD:304358	20/95 (21%)
		Pyr_redox	214..288	CDD:278498	19/78 (24%)
		Pyr_redox_dim	388..497	CDD:280934	29/111 (26%)
Dld	NP_955417.1	lipoamide_DH	43..508	CDD:273568	119/490 (24%)
		NADB_Rossmann	45..222	CDD:304358	41/190 (22%)
		Pyr_redox	215..288	CDD:278498	18/75 (24%)
		Pyr_redox_dim	390..496	CDD:280934	30/112 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1249
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D581771at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820