DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Trxr-2 and Txnrd2

DIOPT Version :9

Sequence 1:	NP_524216.1	Gene:	Trxr-2 / 40475	FlyBaseID:	FBgn0037170	Length:	516	Species:	Drosophila melanogaster
Sequence 2:	NP_038739.2	Gene:	Txnrd2 / 26462	MGIID:	1347023	Length:	527	Species:	Mus musculus

Alignment Length:	510	Identity:	264/510 - (51%)
Similarity:	351/510 - (68%)	Gaps:	7/510 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 RSSTHNALRSSLGWCRLAASRPRYDYDLVVLGGGSAGLACAKEAAGCGARVLCFDYVKPTPVGTK 72
            |..|....|.:.|  ..:|:..:..:||:|:||||.|||||||||..|.:|...|||:|:|.|||
Mouse    20 RPRTRALTRGTRG--AASAAGGQQSFDLLVIGGGSGGLACAKEAAQLGKKVAVADYVEPSPRGTK 82

  Fly    73 WGIGGTCVNVGCIPKKLMHQASLLGEAVHEAVAYGWNVDDTNIRPDWRKLVRSVQNHIKSVNWVT 137
            ||:||||||||||||||||||:|||..:.:|..|||.|... ::.:|:.:..:||||:||:||..
Mouse    83 WGLGGTCVNVGCIPKKLMHQAALLGGMIRDAHHYGWEVAQP-VQHNWKTMAEAVQNHVKSLNWGH 146

  Fly   138 RVDLRDKKVEYVNSMATFRDSHTIEYVAMPGAEHRQVTSEYVVVAVGGRPRYP-DIPGAVELGIT 201
            ||.|:|:||:|.|..|:|.|.||:..|. .|.:...:::|::|:|.||||||| .:.||:|.|||
Mouse   147 RVQLQDRKVKYFNIKASFVDEHTVRGVD-KGGKATLLSAEHIVIATGGRPRYPTQVKGALEYGIT 210

  Fly   202 SDDIFSYEREPGRTLVVGAGYVGLECACFLKGLGYEPTVMVRSIVLRGFDRQMSELLAAMMTERG 266
            |||||..:..||:||||||.||.||||.||.|:|.:.|||:|||.|||||:|||.|:...|...|
Mouse   211 SDDIFWLKESPGKTLVVGASYVALECAGFLTGIGLDTTVMMRSIPLRGFDQQMSSLVTEHMESHG 275

  Fly   267 IPFLGTTIPKAVERQADGRLLVRYRNTTTQMDGSDVFDTVLWAIGRKGLIEDLNLDAAGVKTH-- 329
            ..||...:|..:::....:|.|.:.:..:..:.:..||||||||||......|||:.||:.|:
Mouse   276 TQFLKGCVPSHIKKLPTNQLQVTWEDHASGKEDTGTFDTVLWAIGRVPETRTLNLEKAGISTNPK 340

  Fly   330 DDKIVVDAAEATSVPHIFAVGDIIYGRPELTPVAILSGRLLARRLFAGSTQLMDYADVATTVFTP 394
            :.||:|||.||||||||:|:||:..|||||||.||.:|:|||:|||..|:.||||::|.||||||
Mouse   341 NQKIIVDAQEATSVPHIYAIGDVAEGRPELTPTAIKAGKLLAQRLFGKSSTLMDYSNVPTTVFTP 405

  Fly   395 LEYSCVGMSEETAIELRGADNIEVFHGYYKPTEFFIPQKSVRHCYLKAVAEVSGDQKILGLHYIG 459
            |||.|||:|||.|:.|.|.:::||:|.||||.||.:..:....||:|.|......|.:||||::|
Mouse   406 LEYGCVGLSEEEAVALHGQEHVEVYHAYYKPLEFTVADRDASQCYIKMVCMREPPQLVLGLHFLG 470

  Fly   460 PVAGEVIQGFAAALKTGLTVKTLLNTVGIHPTTAEEFTRLSITKRSGRDPTPASC 514
            |.||||.||||..:|.|.:...::.|||||||.:||..:|.|:||||.:||...|
Mouse   471 PNAGEVTQGFALGIKCGASYAQVMQTVGIHPTCSEEVVKLHISKRSGLEPTVTGC 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Trxr-2	NP_524216.1	NADB_Rossmann	29..>68	CDD:304358	22/38 (58%)
		TGR	31..515	CDD:273624	259/487 (53%)
		NADB_Rossmann	<144..239	CDD:304358	50/95 (53%)
		Pyr_redox	214..288	CDD:278498	37/73 (51%)
		Pyr_redox_dim	388..497	CDD:280934	57/108 (53%)
Txnrd2	NP_038739.2	TGR	43..527	CDD:273624	259/485 (53%)
		NADB_Rossmann	43..>70	CDD:304358	18/26 (69%)
		Pyr_redox	223..289	CDD:278498	36/65 (55%)
		Pyr_redox_dim	399..508	CDD:280934	57/108 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	369	1.000	Domainoid score	I909
eggNOG	1	0.900	-	-		E1_COG1249
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4701
Inparanoid	1	1.050	540	1.000	Inparanoid score	I1165
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57703
OrthoDB	1	1.010	-	-		D164705at33208
OrthoFinder	1	1.000	-	-		FOG0000578
OrthoInspector	1	1.000	-	-		otm42464
orthoMCL	1	0.900	-	-		OOG6_100956
Panther	1	1.100	-	-	O	PTHR48105
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1089
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.840