DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Trxr-2 and pgr1

DIOPT Version :9

Sequence 1:	NP_524216.1	Gene:	Trxr-2 / 40475	FlyBaseID:	FBgn0037170	Length:	516	Species:	Drosophila melanogaster
Sequence 2:	NP_595589.1	Gene:	pgr1 / 2540156	PomBaseID:	SPBC17A3.07	Length:	464	Species:	Schizosaccharomyces pombe

Alignment Length:	491	Identity:	168/491 - (34%)
Similarity:	250/491 - (50%)	Gaps:	59/491 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 YDLVVLGGGSAGLACAKEAAGCGARVLCFDYVKPTPVGTKWGIGGTCVNVGCIPKKLMHQASLLG 97
            :|.:|:||||.|||.|:.||..||:|...:        ....:||||||.||:|||:|
pombe     8 FDYLVIGGGSGGLASARRAAKHGAKVALIE--------ASGRLGGTCVNYGCVPKKIM------- 57

  Fly    98 EAVHEAVAYGWNVDD---------TNIRP-------DWRKLVRSVQNHIKSVNWVTRVDLRDKKV 146
                      ||:.|         .|..|       ||..:.|....:|..:|.:...::....|
pombe    58 ----------WNIADLVAKMKTAKQNGFPNSQLGSFDWGMIKRKRDAYIGRLNGIYERNVNKDGV 112

  Fly   147 EYVNSMATFRDSHTIEYVAMPGAEHRQVTSEYVVVAVGGRPRYPD-IPGAVELGITSDDIFSYER 210
            .|::..|:|.....:......|:..:..:::|:::||||.|.:|. |||| |.||.||..|..|.
pombe   113 AYISGHASFVSPTEVAVDMNDGSGTQVFSAKYILIAVGGHPIWPSHIPGA-EYGIDSDGFFELES 176

  Fly   211 EPGRTLVVGAGYVGLECACFLKGLGYEPTVMVR-SIVLRGFDRQMSELLAAMMTERGIPFLGTTI 274
            :|.|..:|||||:.:|.|.....||.|..:.:| |..||.||..:|:.:.......||.....::
pombe   177 QPKRVAIVGAGYIAVELAGVFAALGTETHMFIRQSKFLRKFDPIISDGIMDHFQHIGINVHTNSL 241

  Fly   275 P-KAVERQADGRLLVRYRNTTTQMDGSDV-FDTVLWAIGRKGLIEDLNLDAAGVKTHDDKIVV-D 336
            . |.||:...|.|.:.      |.|||.. .||:||||||...|:.|.|:.|||||..:.|:: |
pombe   242 EFKKVEKLPSGELCIH------QQDGSTFNVDTLLWAIGRAPKIQGLRLEKAGVKTLPNGIIIAD 300

  Fly   337 AAEATSVPHIFAVGDIIYGRPELTPVAILSGRLLARRLFAGSTQL-MDYADVATTVFTPLEYSCV 400
            ..:.|:||.:.::||:. |:.|||||||.:||.|:.|||.|.... :||.:|.:.||...|...:
pombe   301 TYQRTNVPTVLSLGDVC-GKLELTPVAIAAGRRLSDRLFGGIKDAHLDYEEVPSVVFAHPEAGTI 364

  Fly   401 GMSEETAIELRGADNIEVFHGYYKPTEF-FIPQKSVRHCYLKAVAEVSGD-QKILGLHYIGPVAG 463
            |::|:.||:..|...|:|::..:....: .:.|:.......|.|.  :|. ||::|||.:|..:.
pombe   365 GLTEQEAIDKYGESQIKVYNTKFNGLNYSMVEQEDKVPTTYKLVC--AGPLQKVVGLHLVGDFSA 427

  Fly   464 EVIQGFAAALKTGLTVKTLLNTVGIHPTTAEEFTRL 499
            |::|||..|:|.|.|.....:.|.||||:|||...|
pombe   428 EILQGFGVAIKMGATKSDFDSCVAIHPTSAEELVTL 463

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Trxr-2	NP_524216.1	NADB_Rossmann	29..>68	CDD:304358	15/34 (44%)
		TGR	31..515	CDD:273624	168/491 (34%)
		NADB_Rossmann	<144..239	CDD:304358	35/95 (37%)
		Pyr_redox	214..288	CDD:278498	25/75 (33%)
		Pyr_redox_dim	388..497	CDD:280934	36/110 (33%)
pgr1	NP_595589.1	PRK06116	5..463	CDD:235701	167/489 (34%)
		NADB_Rossmann	20..209	CDD:304358	65/214 (30%)
		Pyr_redox	180..256	CDD:278498	25/75 (33%)
		Pyr_redox_dim	352..462	CDD:280934	36/111 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	176	1.000	Domainoid score	I846
eggNOG	1	0.900	-	-		E1_COG1249
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	253	1.000	Inparanoid score	I769
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000578
OrthoInspector	1	1.000	-	-		otm47011
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R529
SonicParanoid	1	1.000	-	-		X1089
TreeFam	0	0.000	Not matched by this tool.
	8	7.890