DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Trxr-2 and trxr-2

DIOPT Version :9

Sequence 1:	NP_524216.1	Gene:	Trxr-2 / 40475	FlyBaseID:	FBgn0037170	Length:	516	Species:	Drosophila melanogaster
Sequence 2:	NP_498971.1	Gene:	trxr-2 / 176259	WormBaseID:	WBGene00014028	Length:	503	Species:	Caenorhabditis elegans

Alignment Length:	523	Identity:	239/523 - (45%)
Similarity:	328/523 - (62%)	Gaps:	31/523 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSTIKFLRSSTHNALRSSLGWCRLAASRPRYDYDLVVLGGGSAGLACAKEAAGCGARVLCFDYVK 65
            :||.|     .|..:|      ||.:|.   .:||:|:|.||.||:|:|.||..||.|...|.|:
Worm     3 LSTFK-----RHLPIR------RLFSSN---KFDLIVIGAGSGGLSCSKRAADLGANVALIDAVE 53

  Fly    66 PTPVGTKWGIGGTCVNVGCIPKKLMHQASLLGEAVHEAVAYGWN-VDDTNIRPDWRKLVRSVQNH 129
            |||.|..|||||||.|||||||||||||:::|:.:..|..|||| :|...|:.||..|.::|.:.
Worm    54 PTPHGHSWGIGGTCANVGCIPKKLMHQAAIVGKELKHADKYGWNGIDQEKIKHDWNVLSKNVNDR 118

  Fly   130 IKSVNWVTRVDLRDKKVEYVNSMATFRDSHTIEYVAMPGAEHRQ----VTSEYVVVAVGGRPRYP 190
            :|:.||:.||.|..||:.|.|:.|.|.|.   :.:.:.|.:..:    :::..||::.|.||:||
Worm   119 VKANNWIYRVQLNQKKINYFNAYAEFVDK---DKIVITGTDKNKTKNFLSAPNVVISTGLRPKYP 180

  Fly   191 DIPGAVELGITSDDIFSYEREPGRTLVVGAGYVGLECACFLKGLGYEPTVMVRSIVLRGFDRQMS 255
            :|||| ||||||||:|:....||:||:||.|||.||||.||........|:||||.|:||||...
Worm   181 NIPGA-ELGITSDDLFTLASVPGKTLIVGGGYVALECAGFLSAFNQNVEVLVRSIPLKGFDRDCV 244

  Fly   256 ELLAAMMTERGIPFLGTTIPKAVERQADGRLLVRYRNTTTQMDGSDVFDTVLWAIGRKGLIEDLN 320
            ..:...:...|:     .:.:.||.:....:..:.:.|.|...|.:.:|||:||.||...::.||
Worm   245 HFVMEHLKTTGV-----KVKEHVEVERVEAVGSKKKVTFTGNGGVEEYDTVIWAAGRVPNLKSLN 304

  Fly   321 LDAAGVKT--HDDKIVVDAAEATSVPHIFAVGDIIYGRPELTPVAILSGRLLARRLFAGSTQLMD 383
            ||.|||:|  ...||:.|..:..|...::|||||:..|.||||:||.||:|||.|||:.|.|::.
Worm   305 LDNAGVRTDKRSGKILADEFDRASCNGVYAVGDIVQDRQELTPLAIQSGKLLADRLFSNSKQIVR 369

  Fly   384 YADVATTVFTPLEYSCVGMSEETAIELRGADNIEVFHGYYKPTEFFIPQ-KSVRHCYLKAVAEVS 447
            :..||||||||||.|.||::||.||:..|.|:|||||.::.|.|:.:|| |....||:|||....
Worm   370 FDGVATTVFTPLELSTVGLTEEEAIQKHGEDSIEVFHSHFTPFEYVVPQNKDSGFCYVKAVCTRD 434

  Fly   448 GDQKILGLHYIGPVAGEVIQGFAAALKTGLTVKTLLNTVGIHPTTAEEFTRLSITKRSGRDPTPA 512
            ..|||||||::||.|.|||||:|.|.:.|:::..|.||:.|||.::|||.:|.||||||:||...
Worm   435 ESQKILGLHFVGPNAAEVIQGYAVAFRVGISMSDLQNTIAIHPCSSEEFVKLHITKRSGQDPRTQ 499

  Fly   513 SCC 515
            .||
Worm   500 GCC 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Trxr-2	NP_524216.1	NADB_Rossmann	29..>68	CDD:304358	18/38 (47%)
		TGR	31..515	CDD:273624	229/491 (47%)
		NADB_Rossmann	<144..239	CDD:304358	43/98 (44%)
		Pyr_redox	214..288	CDD:278498	26/73 (36%)
		Pyr_redox_dim	388..497	CDD:280934	59/109 (54%)
trxr-2	NP_498971.1	TGR	19..503	CDD:273624	231/496 (47%)
		NADB_Rossmann	20..>49	CDD:304358	15/28 (54%)
		Pyr_redox	203..279	CDD:278498	27/80 (34%)
		Pyr_redox_dim	374..484	CDD:280934	59/109 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	128	1.000	Domainoid score	I3301
eggNOG	1	0.900	-	-		E1_COG1249
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H4701
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57703
OrthoDB	1	1.010	-	-		D164705at33208
OrthoFinder	1	1.000	-	-		FOG0000578
OrthoInspector	1	1.000	-	-		otm14419
orthoMCL	1	0.900	-	-		OOG6_100956
Panther	1	1.100	-	-	O	PTHR48105
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R529
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.860