DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Trxr-2 and gsr-1

DIOPT Version :9

Sequence 1:	NP_524216.1	Gene:	Trxr-2 / 40475	FlyBaseID:	FBgn0037170	Length:	516	Species:	Drosophila melanogaster
Sequence 2:	NP_001021220.1	Gene:	gsr-1 / 175467	WormBaseID:	WBGene00008117	Length:	473	Species:	Caenorhabditis elegans

Alignment Length:	500	Identity:	189/500 - (37%)
Similarity:	277/500 - (55%)	Gaps:	45/500 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 CRLAASRPRY----DYDLVVLGGGSAGLACAKEAAGCGARVLCFDYVKPTPVGTKWGIGGTCVNV 82
            |.|:.||...    ::|.:|:||||.|:|.|:.|...|..|...:..:         :|||||||
Worm     6 CILSTSRSIMSGVKEFDYLVIGGGSGGIASARRAREFGVSVGLIESGR---------LGGTCVNV 61

  Fly    83 GCIPKKLMHQASLLGEAVHEAVAYGWNVDDTNIRPDWRKLVRSVQNHIKSVNWVTRVDLRDKKVE 147
            ||:|||:|:..||..|.:.:...||::|  |..:.||:.:.:|...:||.:|.:....|:...||
Worm    62 GCVPKKVMYNCSLHAEFIRDHADYGFDV--TLNKFDWKVIKKSRDEYIKRLNGLYESGLKGSSVE 124

  Fly   148 YVNSMATFRDSHTIEYVAMPGAEHRQVTSEYVVVAVGGRPRYPDIPGAVELGITSDDIFSYEREP 212
            |:...|||.:..|:|   :.||::|   .:..::||||:|..|:|.|| |.||.||..|..|..|
Worm   125 YIRGRATFAEDGTVE---VNGAKYR---GKNTLIAVGGKPTIPNIKGA-EHGIDSDGFFDLEDLP 182

  Fly   213 GRTLVVGAGYVGLECACFLKGLGYEPTVMVR-SIVLRGFDRQMSELLAAMMTERGIPF---LGTT 273
            .||:||||||:.:|.|..|..||.:..:::| ..|||.||:.:|:.|.|.|.|...|.   ..|.
Worm   183 SRTVVVGAGYIAVEIAGVLANLGSDTHLLIRYDKVLRTFDKMLSDELTADMDEETNPLHLHKNTQ 247

  Fly   274 IPKAVERQADGRLLVRYRNTTTQMDGSDVFDTVLWAIGRKGLIEDLNLDAAGVKTHDDK---IVV 335
            :.:.::.. ||.|.::   |||.:  .:...|::|||||..|.::|||:..||||  ||   |:|
Worm   248 VTEVIKGD-DGLLTIK---TTTGV--IEKVQTLIWAIGRDPLTKELNLERVGVKT--DKSGHIIV 304

  Fly   336 DAAEATSVPHIFAVGDIIYGRPELTPVAILSGRLLARRLFAGST-QLMDYADVATTVFTPLEYSC 399
            |..:.||.|.|.:|||.. |:..||||||.:||.|:.|||.|.| ..:.|.::||.||:......
Worm   305 DEYQNTSAPGILSVGDDT-GKFLLTPVAIAAGRRLSHRLFNGETDNKLTYENIATVVFSHPLIGT 368

  Fly   400 VGMSEETAIELRGADNIEVFHGYYKPTEFFIPQKSVRHCYLKAVAEVSGDQKILGLHYIGPVAGE 464
            ||::|..|:|..|.|.:.::...:.|..|.: .|......:|.|. |..|:|::|:|..|..:.|
Worm   369 VGLTEAEAVEKYGKDEVTLYKSRFNPMLFAV-TKHKEKAAMKLVC-VGKDEKVVGVHVFGVGSDE 431

  Fly   465 VIQGFAAALKTGLTVKTLLNTVGIHPTTAEEFTRLSITKRSGRDP 509
            ::||||.|:..|.|.|....||.||||:|||.    :|.|.|..|
Worm   432 MLQGFAVAVTMGATKKQFDQTVAIHPTSAEEL----VTMRGGVKP 472

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Trxr-2	NP_524216.1	NADB_Rossmann	29..>68	CDD:304358	12/42 (29%)
		TGR	31..515	CDD:273624	184/490 (38%)
		NADB_Rossmann	<144..239	CDD:304358	41/94 (44%)
		Pyr_redox	214..288	CDD:278498	29/77 (38%)
		Pyr_redox_dim	388..497	CDD:280934	40/108 (37%)
gsr-1	NP_001021220.1	PRK06116	19..467	CDD:235701	182/480 (38%)
		Pyr_redox	184..261	CDD:278498	29/77 (38%)
		Pyr_redox_dim	357..465	CDD:280934	40/113 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S706
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D164705at33208
OrthoFinder	1	1.000	-	-		FOG0000578
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R529
SonicParanoid	1	1.000	-	-		X1089
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.900