DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Trxr-2 and DLD

DIOPT Version :9

Sequence 1:	NP_524216.1	Gene:	Trxr-2 / 40475	FlyBaseID:	FBgn0037170	Length:	516	Species:	Drosophila melanogaster
Sequence 2:	NP_000099.2	Gene:	DLD / 1738	HGNCID:	2898	Length:	509	Species:	Homo sapiens

Alignment Length:	506	Identity:	123/506 - (24%)
Similarity:	227/506 - (44%)	Gaps:	54/506 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 RLAASRPRYDYDLVVLGGGSAGLACAKEAAGCGARVLCFDYVKPTPVGTKWGIGGTCVNVGCIPK 87
            |..|.:| .|.|:.|:|.|..|...|.:||..|.:.:|.:..:.        :||||:||||||.
Human    33 RTYADQP-IDADVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNET--------LGGTCLNVGCIPS 88

  Fly    88 KLMHQASLLGEAVHEAVAYGWN-----VDDTNIRPDWRKLVRSVQNHIKSVNWVTRVDLRDKKVE 147
            |     :||..:.:..:|:|.:     ::.:.:|.:..|::......:|::........:..||.
Human    89 K-----ALLNNSHYYHMAHGKDFASRGIEMSEVRLNLDKMMEQKSTAVKALTGGIAHLFKQNKVV 148

  Fly   148 YVNSMATFRDSHTIEYVAMPGAEHRQVTSEYVVVAVGGR-PRYPDIPGAVELGITSDDIFSYERE 211
            :||........:.:......|.. :.:.::.:::|.|.. ..:|.|....:..::|....|.::.
Human   149 HVNGYGKITGKNQVTATKADGGT-QVIDTKNILIATGSEVTPFPGITIDEDTIVSSTGALSLKKV 212

  Fly   212 PGRTLVVGAGYVGLECACFLKGLGYEPTVM-----VRSIVLRGFDRQMSELLAAMMTERGIPFLG 271
            |.:.:|:|||.:|:|.....:.||.:.|.:     |..:   |.|.::|:....::.::|..|..
Human   213 PEKMVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGV---GIDMEISKNFQRILQKQGFKFKL 274

  Fly   272 TTIPKAVERQADGRLLVRYRNTTTQMDGSDVFDTVLWAIGRKGLIEDLNLDAAGVKTHD-DKIVV 335
            .|......:::||::.|.....:.........|.:|..|||:...::|.|:..|::... .:|.|
Human   275 NTKVTGATKKSDGKIDVSIEAASGGKAEVITCDVLLVCIGRRPFTKNLGLEELGIELDPRGRIPV 339

  Fly   336 DAAEATSVPHIFAVGDIIYGRPELTPVAILSGRLLARRLFAGSTQLMDYADVATTVFTPLEYSCV 400
            :....|.:|:|:|:||::.| |.|...|...|.:....:..|:..: ||..|.:.::|..|.:.|
Human   340 NTRFQTKIPNIYAIGDVVAG-PMLAHKAEDEGIICVEGMAGGAVHI-DYNCVPSVIYTHPEVAWV 402

  Fly   401 GMSEETAIELRGADNIEVFHGYYKPTEFFIPQKSVRHCYLKAVAEVSG---------DQKILGLH 456
            |.|||...|    :.||     ||..:|.....|    ..|..|:..|         ..::||.|
Human   403 GKSEEQLKE----EGIE-----YKVGKFPFAANS----RAKTNADTDGMVKILGQKSTDRVLGAH 454

  Fly   457 YIGPVAGEVIQGFAAALKTGLTVKTLLNTVGIHPTTAEEFTRLSITKRSGR 507
            .:||.|||::...|.||:.|.:.:.:......|||.:|.|...::....|:
Human   455 ILGPGAGEMVNEAALALEYGASCEDIARVCHAHPTLSEAFREANLAASFGK 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Trxr-2	NP_524216.1	NADB_Rossmann	29..>68	CDD:304358	12/38 (32%)
		TGR	31..515	CDD:273624	120/498 (24%)
		NADB_Rossmann	<144..239	CDD:304358	20/95 (21%)
		Pyr_redox	214..288	CDD:278498	18/78 (23%)
		Pyr_redox_dim	388..497	CDD:280934	33/117 (28%)
DLD	NP_000099.2	Pyr_redox_dim	43..509	CDD:332164	119/495 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1249
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D581771at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820