DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Trxr-2 and TXNRD2

DIOPT Version :9

Sequence 1:	NP_524216.1	Gene:	Trxr-2 / 40475	FlyBaseID:	FBgn0037170	Length:	516	Species:	Drosophila melanogaster
Sequence 2:	NP_006431.2	Gene:	TXNRD2 / 10587	HGNCID:	18155	Length:	524	Species:	Homo sapiens

Alignment Length:	498	Identity:	274/498 - (55%)
Similarity:	352/498 - (70%)	Gaps:	6/498 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 GWCRLAASRPRYDYDLVVLGGGSAGLACAKEAAGCGARVLCFDYVKPTPVGTKWGIGGTCVNVGC 84
            |..|.||:..| ||||:|:||||.|||||||||..|.:|...|||:|:|.||:||:|||||||||
Human    28 GAARGAAAGQR-DYDLLVVGGGSGGLACAKEAAQLGRKVAVVDYVEPSPQGTRWGLGGTCVNVGC 91

  Fly    85 IPKKLMHQASLLGEAVHEAVAYGWNVDDTNIRPDWRKLVRSVQNHIKSVNWVTRVDLRDKKVEYV 149
            |||||||||:|||..:.:|..|||.|... :..||||:..:||||:||:||..||.|:|:||:|.
Human    92 IPKKLMHQAALLGGLIQDAPNYGWEVAQP-VPHDWRKMAEAVQNHVKSLNWGHRVQLQDRKVKYF 155

  Fly   150 NSMATFRDSHTIEYVAMPGAEHRQVTSEYVVVAVGGRPRYP-DIPGAVELGITSDDIFSYEREPG 213
            |..|:|.|.||:..||..|.| ..::::::::|.||||||| .|.||:|.||||||||..:..||
Human   156 NIKASFVDEHTVCGVAKGGKE-ILLSADHIIIATGGRPRYPTHIEGALEYGITSDDIFWLKESPG 219

  Fly   214 RTLVVGAGYVGLECACFLKGLGYEPTVMVRSIVLRGFDRQMSELLAAMMTERGIPFLGTTIPKAV 278
            :||||||.||.||||.||.|:|.:.|:|:|||.|||||:|||.::...|...|..||....|..|
Human   220 KTLVVGASYVALECAGFLTGIGLDTTIMMRSIPLRGFDQQMSSMVIEHMASHGTRFLRGCAPSRV 284

  Fly   279 ERQADGRLLVRYRNTTTQMDGSDVFDTVLWAIGRKGLIEDLNLDAAGVKTHDD--KIVVDAAEAT 341
            .|..||:|.|.:.::||..:.:..||||||||||......|||:.|||.|..|  ||:||:.|||
Human   285 RRLPDGQLQVTWEDSTTGKEDTGTFDTVLWAIGRVPDTRSLNLEKAGVDTSPDTQKILVDSREAT 349

  Fly   342 SVPHIFAVGDIIYGRPELTPVAILSGRLLARRLFAGSTQLMDYADVATTVFTPLEYSCVGMSEET 406
            |||||:|:||::.|||||||:||::||||.:|||.||:.||||.:|.|||||||||.|||:|||.
Human   350 SVPHIYAIGDVVEGRPELTPIAIMAGRLLVQRLFGGSSDLMDYDNVPTTVFTPLEYGCVGLSEEE 414

  Fly   407 AIELRGADNIEVFHGYYKPTEFFIPQKSVRHCYLKAVAEVSGDQKILGLHYIGPVAGEVIQGFAA 471
            |:...|.:::||:|.:|||.||.:..:....||:|.|......|.:||||::||.||||.||||.
Human   415 AVARHGQEHVEVYHAHYKPLEFTVAGRDASQCYVKMVCLREPPQLVLGLHFLGPNAGEVTQGFAL 479

  Fly   472 ALKTGLTVKTLLNTVGIHPTTAEEFTRLSITKRSGRDPTPASC 514
            .:|.|.:...::.|||||||.:||..:|.|:||||.|||...|
Human   480 GIKCGASYAQVMRTVGIHPTCSEEVVKLRISKRSGLDPTVTGC 522

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Trxr-2	NP_524216.1	NADB_Rossmann	29..>68	CDD:304358	25/38 (66%)
		TGR	31..515	CDD:273624	269/487 (55%)
		NADB_Rossmann	<144..239	CDD:304358	51/95 (54%)
		Pyr_redox	214..288	CDD:278498	39/73 (53%)
		Pyr_redox_dim	388..497	CDD:280934	55/108 (51%)
TXNRD2	NP_006431.2	TGR	39..524	CDD:273624	269/486 (55%)
		FMT_C_like	124..>190	CDD:301347	30/66 (45%)
		Pyr_redox	220..295	CDD:278498	39/74 (53%)
		Pyr_redox_dim	396..505	CDD:280934	55/108 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	380	1.000	Domainoid score	I847
eggNOG	1	0.900	-	-		E1_COG1249
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4701
Inparanoid	1	1.050	551	1.000	Inparanoid score	I1134
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57703
OrthoDB	1	1.010	-	-		D164705at33208
OrthoFinder	1	1.000	-	-		FOG0000578
OrthoInspector	1	1.000	-	-		otm40392
orthoMCL	1	0.900	-	-		OOG6_100956
Panther	1	1.100	-	-	O	PTHR48105
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1089
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.840