DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Trxr-2 and txnrd2

DIOPT Version :9

Sequence 1:	NP_524216.1	Gene:	Trxr-2 / 40475	FlyBaseID:	FBgn0037170	Length:	516	Species:	Drosophila melanogaster
Sequence 2:	NP_001120487.2	Gene:	txnrd2 / 100145605	XenbaseID:	XB-GENE-5767949	Length:	504	Species:	Xenopus tropicalis

Alignment Length:	488	Identity:	278/488 - (56%)
Similarity:	354/488 - (72%)	Gaps:	5/488 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 RYDYDLVVLGGGSAGLACAKEAAGCGARVLCFDYVKPTPVGTKWGIGGTCVNVGCIPKKLMHQAS 94
            |:||||:|:||||.||||||:||..|.:|..||||:|:|.||||||||||||||||||||||||:
Frog    17 RHDYDLLVIGGGSGGLACAKQAAQFGKKVAVFDYVEPSPRGTKWGIGGTCVNVGCIPKKLMHQAA 81

  Fly    95 LLGEAVHEAVAYGWNVDDTNIRPDWRKLVRSVQNHIKSVNWVTRVDLRDKKVEYVNSMATFRDSH 159
            |:|..:.:|..|||:..: .|:.:|.|:.::|||::||:||..|:.|:||||:|.|..|:|.|.|
Frog    82 LIGSTLKDAPHYGWDTPN-EIQHNWGKMAKAVQNYVKSLNWGHRIQLQDKKVKYFNMKASFVDEH 145

  Fly   160 TIEYVAMPGAEHRQVTSEYVVVAVGGRPRYP-DIPGAVELGITSDDIFSYEREPGRTLVVGAGYV 223
            .|..|...|.| ..||:|.:|:|.||||:|| .:|||:|.||||||:|..:..||:||||||.||
Frog   146 CIRGVTKAGKE-TLVTAENIVIATGGRPKYPTHVPGALEYGITSDDLFWLKESPGKTLVVGASYV 209

  Fly   224 GLECACFLKGLGYEPTVMVRSIVLRGFDRQMSELLAAMMTERGIPFLGTTIPKAVERQADGRLLV 288
            .||||.||.|:|.:...|||||.|||||:||:.|:...|...|..||....|..||:..:|:|.|
Frog   210 SLECAGFLTGIGLDTAAMVRSIPLRGFDQQMAYLVTDYMELHGTKFLWKCTPSNVEKLKNGKLEV 274

  Fly   289 RYRNTTTQMDGSDVFDTVLWAIGRKGLIEDLNLDAAGVKTHDD--KIVVDAAEATSVPHIFAVGD 351
            .::||.:..:|:|::|||:||:||....:.|||:..||....|  ||:|:|:||||||||:|:||
Frog   275 TWKNTESGKEGADIYDTVMWAVGRAAETQYLNLEKVGVDVKSDTGKIIVNASEATSVPHIYAIGD 339

  Fly   352 IIYGRPELTPVAILSGRLLARRLFAGSTQLMDYADVATTVFTPLEYSCVGMSEETAIELRGADNI 416
            |..|||||||.||.:|:|||.|||:||.:||||..|.|||||||||.|||:|||.|.|..|.|||
Frog   340 ITEGRPELTPTAIAAGKLLASRLFSGSAELMDYDSVPTTVFTPLEYGCVGISEEDAKERYGDDNI 404

  Fly   417 EVFHGYYKPTEFFIPQKSVRHCYLKAVAEVSGDQKILGLHYIGPVAGEVIQGFAAALKTGLTVKT 481
            ||||.:|||.||.:.:::...||:|.:...:.||:|||||:.||.|||||||||..:|.|.|...
Frog   405 EVFHAFYKPLEFIVAERNGSQCYIKIICLRTQDQRILGLHFTGPNAGEVIQGFALGIKCGATYHQ 469

  Fly   482 LLNTVGIHPTTAEEFTRLSITKRSGRDPTPASC 514
            |:.|||||||.|||.|:|.||||||.|||...|
Frog   470 LMRTVGIHPTCAEEVTKLHITKRSGLDPTVTGC 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Trxr-2	NP_524216.1	NADB_Rossmann	29..>68	CDD:304358	25/37 (68%)
		TGR	31..515	CDD:273624	277/487 (57%)
		NADB_Rossmann	<144..239	CDD:304358	53/95 (56%)
		Pyr_redox	214..288	CDD:278498	38/73 (52%)
		Pyr_redox_dim	388..497	CDD:280934	65/108 (60%)
txnrd2	NP_001120487.2	Pyr_redox_dim	18..504	CDD:332164	277/487 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	391	1.000	Domainoid score	I778
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H4701
Inparanoid	1	1.050	579	1.000	Inparanoid score	I1018
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D164705at33208
OrthoFinder	1	1.000	-	-		FOG0000578
OrthoInspector	1	1.000	-	-		otm47567
Panther	1	1.100	-	-	O	PTHR48105
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R529
SonicParanoid	1	1.000	-	-		X1089
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	9.190