DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11426 and Plpp2

DIOPT Version :9

Sequence 1:	NP_649394.1	Gene:	CG11426 / 40471	FlyBaseID:	FBgn0037166	Length:	340	Species:	Drosophila melanogaster
Sequence 2:	NP_056632.2	Gene:	Plpp2 / 50784	MGIID:	1354945	Length:	276	Species:	Mus musculus

Alignment Length:	297	Identity:	105/297 - (35%)
Similarity:	151/297 - (50%)	Gaps:	43/297 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 LLVELLVVVVLVIPICVYEFAVDPVRRGFFCDDESISYPFQDNTIT-PVMLGLIVGLLPALVMVV 101
            :|:::|.|:|..:|..:......|.:|||:|.|:||.||::.:||| .:|.|:|:.....||.:.
Mouse     8 VLLDVLCVLVASLPFIILTLVNAPYKRGFYCGDDSIRYPYRPDTITHGLMAGVIITATVILVSLG 72

  Fly   102 VEYVSHLRAGDISATVDLLGWR------VSTWYVELGRQSTYFCFGLLLTFDATEVGKYTIGRLR 160
            ..|:.:         .|.|..|      |:..|..||.    |.||..::...|::.||.|||||
Mouse    73 EAYLVY---------TDRLYSRSNFNNYVAAIYKVLGT----FLFGAAVSQSLTDLAKYMIGRLR 124

  Fly   161 PHFLAVCQPQIADGSMCSDPVNLHRYMENYDCAGEGFTVEDVRQARLSFPSGHSSLAFYAMIYVA 225
            |.|||||.|   |.|.    ||...|::...|.|   :..:|.:|||||.|||||...|.|:::|
Mouse   125 PSFLAVCDP---DWSQ----VNCSGYVQLEVCRG---SPANVTEARLSFYSGHSSFGMYCMLFLA 179

  Fly   226 LYLQRKITWRGSKLSRHFVQFAVVMVAWYTALSRVMDHWHHWSDVLSGSLLGVAGALITAHYIAR 290
            ||:|.::.|:.::|.|..|||.:|..|.|...:||.||.|||||||.|.|.|...|.:|..|::.
Mouse   180 LYVQARLCWKWARLLRPTVQFFLVAFAIYVGYTRVSDHKHHWSDVLVGLLQGALVACLTVRYVSD 244

  Fly   291 MFDDGASNILSGGLRRENTAATLQEEVCPTTPPPYSV 327
            .|             :.......||:..|...|..|:
Mouse   245 FF-------------KSRPPQPCQEDEVPERKPSLSL 268

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11426	NP_649394.1	PAP2_wunen	130..285	CDD:239479	68/154 (44%)
Plpp2	NP_056632.2	PAP2_wunen	94..239	CDD:239479	69/158 (44%)
		Phosphatase sequence motif I. /evidence=ECO:0000250\|UniProtKB:O34349	117..125		6/7 (86%)
		Phosphatase sequence motif II. /evidence=ECO:0000250\|UniProtKB:O34349	164..167		1/2 (50%)
		Phosphatase sequence motif III. /evidence=ECO:0000250\|UniProtKB:O34349	212..223		7/10 (70%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	251..276		5/18 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167834791
Domainoid	1	1.000	159	1.000	Domainoid score	I4068
eggNOG	1	0.900	-	-		E1_COG0671
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	204	1.000	Inparanoid score	I3731
Isobase	1	0.950	-	0	Normalized mean entropy	S2943
OMA	1	1.010	-	-		QHG48083
OrthoDB	1	1.010	-	-		D434801at33208
OrthoFinder	1	1.000	-	-		FOG0000694
OrthoInspector	1	1.000	-	-		mtm8794
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10165
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X571
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.910