DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11426 and PLPP4

DIOPT Version :9

Sequence 1:	NP_649394.1	Gene:	CG11426 / 40471	FlyBaseID:	FBgn0037166	Length:	340	Species:	Drosophila melanogaster
Sequence 2:	NP_001025230.1	Gene:	PLPP4 / 196051	HGNCID:	23531	Length:	271	Species:	Homo sapiens

Alignment Length:	266	Identity:	74/266 - (27%)
Similarity:	106/266 - (39%)	Gaps:	55/266 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 QRLLVELLVVVVLVIPICVYEFAVDPVRRGFFCDDESI---SYPF--QDNTITPVMLGLIVGLLP 95
            :.|.:| :.|..|:..:.|:...:||.:|  ....|.|   ..|.  .||..|.:|.. |..|.|
Human     2 RELAIE-IGVRALLFGVFVFTEFLDPFQR--VIQPEEIWLYKNPLVQSDNIPTRLMFA-ISFLTP 62

  Fly    96 ALVMVVVEYVSHLRAGDISATVDLLGWRVSTWYVELGRQSTYFCFGLLLTFD--ATEVGKYTIGR 158
            ..|:.||:.:......:|                    :..:....|.|..:  .|...|..:||
Human    63 LAVICVVKIIRRTDKTEI--------------------KEAFLAVSLALALNGVCTNTIKLIVGR 107

  Fly   159 LRPHFLAVCQPQIADGSMCSDPVNLHRYMENYDCAGEGFTVEDVRQARLSFPSGHSSLAFYAMIY 223
            .||.|...|.|   ||.|.|:   :|       |.|:   .:.|.:.|.||||.|||.||..:.:
Human   108 PRPDFFYRCFP---DGVMNSE---MH-------CTGD---PDLVSEGRKSFPSIHSSFAFSGLGF 156

  Fly   224 VALYLQRKI-----TWRGSKLSRHFVQFAVVMVAWYTALSRVMDHWHHWSDVLSGSLLGVAGALI 283
            ...||..|:     :.|| |..|.......:..|...||||:.|:.|||.|...|.::|:..|.|
Human   157 TTFYLAGKLHCFTESGRG-KSWRLCAAILPLYCAMMIALSRMCDYKHHWQDSFVGGVIGLIFAYI 220

  Fly   284 --TAHY 287
              ..||
Human   221 CYRQHY 226

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11426	NP_649394.1	PAP2_wunen	130..285	CDD:239479	50/163 (31%)
PLPP4	NP_001025230.1	PAP2_containing_1_like	37..225	CDD:239484	62/225 (28%)
		Phosphatase sequence motif I. /evidence=ECO:0000269\|PubMed:17590538	102..110		3/7 (43%)
		Phosphatase sequence motif II. /evidence=ECO:0000269\|PubMed:17590538	143..146		2/2 (100%)
		Phosphatase sequence motif III. /evidence=ECO:0000269\|PubMed:17590538	195..205		5/9 (56%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	250..271
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144665
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0671
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100228
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.730