DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment laza and Plpp5

DIOPT Version :9

Sequence 1:	NP_649391.1	Gene:	laza / 40468	FlyBaseID:	FBgn0037163	Length:	334	Species:	Drosophila melanogaster
Sequence 2:	NP_082276.1	Gene:	Plpp5 / 71910	MGIID:	1919160	Length:	260	Species:	Mus musculus

Alignment Length:	227	Identity:	66/227 - (29%)
Similarity:	93/227 - (40%)	Gaps:	68/227 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 MLFVAVVEIMRICKRFRTRLYFRNLW-----RAEATF---------------SFGFIATYLT--- 79
            :||||.: :..:...|:.|:....||     ..||.:               |..|:|.:|.
Mouse    15 LLFVAFL-VTELLPPFQRRIQPEELWLYRNPYVEAEYFPTGRMFVIAFLTPLSLIFLAKFLRKAD 78

  Fly    80 ---------------------TELAKHAVGRLRPHFFHGCQPRLDDGSSCSDLQNAELYVEQFHC 123
                                 |.:.|..|||.||.||:.|.|   ||.:.|||.          |
Mouse    79 ATDSKQACLAASLALALNGVFTNIIKLIVGRPRPDFFYRCFP---DGLAHSDLT----------C 130

  Fly   124 TNNNLSTRQIRELHVSFPSAHSSLSFYSMVLLALYVHG-----VWRGRGGVRVLRHVLQFLLLMA 183
            |.:.   ..:.|...||||.|||.:|..:...:.|:.|     ..:|||....|...|..||..|
Mouse   131 TGDE---DVVNEGRKSFPSGHSSFAFAGLAFASFYLAGKLHCFTPQGRGKSWRLCAFLSPLLFAA 192

  Fly   184 ALCVSLSRVADYWHHWSDVLAGALLGVTYAAI 215
            .  ::|||..||.|||.|||.|:::|:|:|.:
Mouse   193 V--IALSRTCDYKHHWQDVLVGSMIGMTFAYV 222

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
laza	NP_649391.1	PAP2_wunen	62..217	CDD:239479	60/203 (30%)
Plpp5	NP_082276.1	PAP2_containing_1_like	39..227	CDD:239484	59/202 (29%)
		Phosphatase sequence motif I. /evidence=ECO:0000250\|UniProtKB:Q8NEB5	104..112		4/7 (57%)
		Phosphatase sequence motif II. /evidence=ECO:0000250\|UniProtKB:Q8NEB5	145..148		2/2 (100%)
		Phosphatase sequence motif III. /evidence=ECO:0000250\|UniProtKB:Q8NEB5	197..207		6/9 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167834799
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0671
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S2488
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1621899at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3374
SonicParanoid	1	1.000	-	-		X622
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.730