DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment laza and Plpp4

DIOPT Version :9

Sequence 1:	NP_649391.1	Gene:	laza / 40468	FlyBaseID:	FBgn0037163	Length:	334	Species:	Drosophila melanogaster
Sequence 2:	NP_001074432.1	Gene:	Plpp4 / 381925	MGIID:	2685936	Length:	271	Species:	Mus musculus

Alignment Length:	256	Identity:	71/256 - (27%)
Similarity:	104/256 - (40%)	Gaps:	69/256 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 YKDCTI---TVPMLLLMML--LLPMLFVAVVEIMRICKRFRTRLYFRNLWRAEAT-FSFGFIATY 77
            ||:..:   .:|..|:..:  |.|:..:.||:|:|               |.:.| ....|:|..
Mouse    39 YKNPLVQSDNIPTRLMFAISFLTPLAVICVVKIIR---------------RTDKTEIKEAFLAVS 88

  Fly    78 LT-------TELAKHAVGRLRPHFFHGCQPRLDDGSSCSDLQNAELYVEQFHCTNNNLSTRQIRE 135
            |.       |...|..|||.||.||:.|.|   ||     :.|:|:     .||.:   ...:.|
Mouse    89 LALALNGVCTNTIKLIVGRPRPDFFYRCFP---DG-----VMNSEM-----RCTGD---PDLVSE 137

  Fly   136 LHVSFPSAHSSLSFYSMVLLALYVHG-----VWRGRGGVRVLRHVLQFLLLMAALCVSLSRVADY 195
            ...||||.|||.:|..:.....|:.|     ...|||  :..|.....|.|..|:.::|||:.||
Mouse   138 GRKSFPSIHSSFAFSGLGFTTFYLAGKLHCFTESGRG--KSWRLCAAILPLYCAMMIALSRMCDY 200

  Fly   196 WHHWSDVLAGALLGVTYAAI-----------TAAY-------VGNLLRRQTSSTGRIPPSL 238
            .|||.|...|.::|:.:|.|           ||.:       |...|:::...|....|||
Mouse   201 KHHWQDSFVGGVIGLIFAYICYRQHYPPLANTACHKPYVSLRVPTSLKKEERPTADSAPSL 261

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
laza	NP_649391.1	PAP2_wunen	62..217	CDD:239479	53/178 (30%)
Plpp4	NP_001074432.1	PAP2_containing_1_like	37..225	CDD:239484	63/218 (29%)
		Phosphatase sequence motif I. /evidence=ECO:0000250\|UniProtKB:Q5VZY2	102..110		4/7 (57%)
		Phosphatase sequence motif II. /evidence=ECO:0000250\|UniProtKB:Q5VZY2	143..146		2/2 (100%)
		Phosphatase sequence motif III. /evidence=ECO:0000250\|UniProtKB:Q5VZY2	195..205		6/9 (67%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	249..271		4/13 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167834778
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0671
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1621899at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3374
SonicParanoid	1	1.000	-	-		X622
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.780