DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment laza and Plppr4

DIOPT Version :9

Sequence 1:	NP_649391.1	Gene:	laza / 40468	FlyBaseID:	FBgn0037163	Length:	334	Species:	Drosophila melanogaster
Sequence 2:	NP_001001508.2	Gene:	Plppr4 / 295401	RGDID:	727806	Length:	766	Species:	Rattus norvegicus

Alignment Length:	352	Identity:	81/352 - (23%)
Similarity:	137/352 - (38%)	Gaps:	64/352 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 GFFCSDLSIRYPYKDCT-ITVPMLLLMMLLL--PMLFVAVVEIMRICKRFRTR------------ 56
            ||.|.|.|:..||.:.| ..:|.|:|:.|..  |.:.:.|.|.:..|...:.|
  Rat   101 GFSCYDRSLSMPYIEPTQEAIPFLMLLSLAFAGPAITIMVGEGILYCCLSKRRNGAGLEPNINAG 165

  Fly    57 -----LYFRNLWRAEATFSFGFIATYLTTELAKHAVGRLRPHFFHGCQPRLDD-GSSCSDLQNAE 115
                 .:.|...|......||..:|.|.|::.:.:.|...|:|...|:|.... ..||.:    .
  Rat   166 GCNFNSFLRRAVRFVGVHVFGLCSTALITDIIQLSTGYQAPYFLTVCKPNYTSLNVSCKE----N 226

  Fly   116 LYVEQFHCTNNNLSTRQIRELHVSFPSAHSSLSFYSMVLLALYVHGVWRGRGGVRVLRHVLQFLL 180
            .|:.:..|:.::|:.  |.....||||.|::|:.::.|.:::|.:.......  ::|:.:|.|..
  Rat   227 SYIVEDICSGSDLTV--INSGRKSFPSQHATLAAFAAVYVSMYFNSTLTDSS--KLLKPLLVFTF 287

  Fly   181 LMAALCVSLSRVADYWHHWSDVLAGALLGVTYAAITAAY-VGNLLRRQTS--------------- 229
            ::..:...|:|:..|.:|..||..|.|:|...|.....| |||.|..:.|
  Rat   288 IICGIICGLTRITQYKNHPVDVYCGFLIGGGIALYLGLYAVGNFLPSEDSMLQHRDALRSLTDLN 352

  Fly   230 -STGRIPPSLNYSHH---LHHQLMADNNNSTASAKVHFLAAAASASMTT-------------TTP 277
             ...|:..:.|.|..   .|.:.:.:.|:..||:..:...|.|...:.|             :..
  Rat   353 QDPSRVLSAKNGSSGDGIAHTEGILNRNHRDASSLTNLKRANADVEIITPRSPMGKESMVTFSNT 417

  Fly   278 LDDIQDSDVEDSRDCRDSEDSHDSQDS 304
            |.......|||  ..|.:...|.|.||
  Rat   418 LPRANTPSVED--PVRRNASIHASMDS 442

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
laza	NP_649391.1	PAP2_wunen	62..217	CDD:239479	38/155 (25%)
Plppr4	NP_001001508.2	PAP2_wunen	175..324	CDD:239479	38/156 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	454..503
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	510..529
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	634..654
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	672..705
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	741..766
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166338338
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0671
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1621899at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.750