DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment laza and Plpp2

DIOPT Version :9

Sequence 1:	NP_649391.1	Gene:	laza / 40468	FlyBaseID:	FBgn0037163	Length:	334	Species:	Drosophila melanogaster
Sequence 2:	NP_640345.1	Gene:	Plpp2 / 246115	RGDID:	628893	Length:	276	Species:	Rattus norvegicus

Alignment Length:	254	Identity:	89/254 - (35%)
Similarity:	127/254 - (50%)	Gaps:	36/254 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 FKRGFFCSDLSIRYPYKDCTITVPMLLLMMLLLPMLFVAVVEIMRICKRFRTRLYFRN------- 61
            :||||:|.|.||||||:..|||..::..:::...::.|:..|...:   :..|||.|:
  Rat    32 YKRGFYCGDDSIRYPYRPDTITHGLMAGVIITATVVLVSSGEAYLV---YTDRLYSRSDFNNYVA 93

  Fly    62 -LWRAEATFSFGFIATYLTTELAKHAVGRLRPHFFHGCQPRLDDGS--SCSDLQNAELYVEQFHC 123
             :::...||.||...:...|:|||:.:|||||.|...|.|   |.|  :||.      ||:...|
  Rat    94 AIYKVLGTFLFGAAVSQSLTDLAKYMIGRLRPSFLAVCDP---DWSRVNCSG------YVQVEVC 149

  Fly   124 TNNNLSTRQIRELHVSFPSAHSSLSFYSMVLLALYVHG--VWRGRGGVRVLRHVLQFLLLMAALC 186
            ..   |...:.|..:||.|.|||...|.|:.|||||..  .|:   ..|:||..:||.|:..|:.
  Rat   150 RG---SPANVTEARLSFYSGHSSFGMYCMLFLALYVQARLCWK---WARLLRPTVQFFLVAFAIY 208

  Fly   187 VSLSRVADYWHHWSDVLAGALLGVTYAAITAAYVGNLLRR------QTSSTGRIPPSLN 239
            |..:||:|..|||||||.|.|.|...|.:|..||.:..:.      |.:......|||:
  Rat   209 VGYTRVSDNKHHWSDVLVGLLQGALVACLTVCYVSDFFKSRPPQSCQENEESERKPSLS 267

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
laza	NP_649391.1	PAP2_wunen	62..217	CDD:239479	61/158 (39%)
Plpp2	NP_640345.1	PAP2_wunen	94..239	CDD:239479	61/159 (38%)
		Phosphatase sequence motif I. /evidence=ECO:0000250\|UniProtKB:O34349	117..125		4/7 (57%)
		Phosphatase sequence motif II. /evidence=ECO:0000250\|UniProtKB:O34349	164..167		1/2 (50%)
		Phosphatase sequence motif III. /evidence=ECO:0000250\|UniProtKB:O34349	212..223		6/10 (60%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	252..276		4/16 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166338374
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0671
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48083
OrthoDB	1	1.010	-	-		D1621899at2759
OrthoFinder	1	1.000	-	-		FOG0000694
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10165
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	9	8.820