DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment laza and Plppr3

DIOPT Version :9

Sequence 1:	NP_649391.1	Gene:	laza / 40468	FlyBaseID:	FBgn0037163	Length:	334	Species:	Drosophila melanogaster
Sequence 2:	NP_859009.2	Gene:	Plppr3 / 216152	MGIID:	2388640	Length:	716	Species:	Mus musculus

Alignment Length:	458	Identity:	101/458 - (22%)
Similarity:	163/458 - (35%)	Gaps:	142/458 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 KRGFFCSDLSIRYPYKDCT-ITVPMLLLMMLLL--PMLFVAVVEIMRICKRFRTRLYFRNLWRAE 66
            |.||.|.|.::..||.:.. ..:|:|:|:.|..  |...:.|.|.|..|  .::||:.|.....|
Mouse    49 KVGFQCYDRALSMPYVETNEELIPLLMLLSLAFAAPAASIMVGEGMVYC--LQSRLWGRGPGGVE 111

  Fly    67 ATFS---------------------FGFIATYLTTELAKHAVGRLRPHFFHGCQPRLD-DGSSCS 109
            .:.:                     ||..||.|.|::.:.|.|...|.|...|:|... .|:||
Mouse   112 GSINAGGCNFNSFLRRTVRFVGVHVFGLCATALVTDVIQLATGYHTPFFLTVCKPNYTLLGTSC- 175

  Fly   110 DLQNAELYVEQFHCTNNNLSTRQIRELHVSFPSAHSSLSFYSMVLLALYVHGVWRGRGGVRVLRH 174
               .:..|:.|..|:.::  |..|.....:|||.|::||.::.|.:::|.:.|....  .::|:.
Mouse   176 ---ESNPYITQDICSGHD--THAILSARKTFPSQHATLSAFAAVYVSMYFNAVISDT--TKLLKP 233

  Fly   175 VLQFLLLMAALCVSLSRVADYWHHWSDVLAGALLGVTYAAITAAY-VGNLLRRQTSSTGRIP--- 235
            :|.|...:||....|:::..|..|..||.||.|:|...||..|.: |||.   |.....::|
Mouse   234 ILVFAFAIAAGVCGLTQITQYRSHPVDVYAGFLIGAGIAAYLACHAVGNF---QAPPAEKVPTPA 295

  Fly   236 ---PSLNYSHHLHHQLMADNNNST------------------------------ASAKVHFLAA- 266
               .:|.......|:.|...|.|.                              ||..|..||.
Mouse   296 PAKDALRALTQRGHESMYQQNKSVSTDELGPPGRLEGVPRPVAREKTSLGSLKRASVDVDLLAPR 360

  Fly   267 -------------------------AASASMTTTTPLDDIQDSDV-----EDSRDCRD------- 294
                                     .|...||...|||..:...:     :.|.:.|.
Mouse   361 SPMGKEGMVTFSNTLPRVSTPSLDDPARRHMTIHVPLDASRSRQLIGEWKQKSLEGRGLGLPDEA 425

  Fly   295 ------------SEDSHDSQDSHAENEDDNEE-------VYKSQMSRP------VTP----PTDL 330
                        :|:..:.::...|.|::.||       :|.:..:||      :.|    |..|
Mouse   426 SPVHLRAPAEQVAEEEEEEEEEEEEEEEEEEEEGPVPPSLYPTVQARPGLGPRVILPPRPGPQPL 490

  Fly   331 THV 333
            .|:
Mouse   491 VHI 493

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
laza	NP_649391.1	PAP2_wunen	62..217	CDD:239479	46/176 (26%)
Plppr3	NP_859009.2	PAP2_wunen	127..276	CDD:239479	45/156 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	311..335		3/23 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	416..515		13/78 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	548..589
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	630..651
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	663..693
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167834785
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0671
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1621899at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.750