DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment laza and PLPP4

DIOPT Version :9

Sequence 1:	NP_649391.1	Gene:	laza / 40468	FlyBaseID:	FBgn0037163	Length:	334	Species:	Drosophila melanogaster
Sequence 2:	NP_001025230.1	Gene:	PLPP4 / 196051	HGNCID:	23531	Length:	271	Species:	Homo sapiens

Alignment Length:	286	Identity:	81/286 - (28%)
Similarity:	116/286 - (40%)	Gaps:	71/286 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 YKDCTI---TVPMLLLMML--LLPMLFVAVVEIMRICKRFRTRLYFRNLWRAEAT-FSFGFIATY 77
            ||:..:   .:|..|:..:  |.|:..:.||:|:|               |.:.| ....|:|..
Human    39 YKNPLVQSDNIPTRLMFAISFLTPLAVICVVKIIR---------------RTDKTEIKEAFLAVS 88

  Fly    78 LT-------TELAKHAVGRLRPHFFHGCQPRLDDGSSCSDLQNAELYVEQFHCTNNNLSTRQIRE 135
            |.       |...|..|||.||.||:.|.|   ||     :.|:|:     |||.:   ...:.|
Human    89 LALALNGVCTNTIKLIVGRPRPDFFYRCFP---DG-----VMNSEM-----HCTGD---PDLVSE 137

  Fly   136 LHVSFPSAHSSLSFYSMVLLALYVHG-----VWRGRGGVRVLRHVLQFLLLMAALCVSLSRVADY 195
            ...||||.|||.:|..:.....|:.|     ...|||  :..|.....|.|..|:.::|||:.||
Human   138 GRKSFPSIHSSFAFSGLGFTTFYLAGKLHCFTESGRG--KSWRLCAAILPLYCAMMIALSRMCDY 200

  Fly   196 WHHWSDVLAGALLGVTYAAITAAYVGNLLRRQTSSTGRIPPSLNYSHHLHHQLMADNNNSTASAK 260
            .|||.|...|.::|:.:|.|  .|      ||     ..||..|.:.|..:..:    ...||.|
Human   201 KHHWQDSFVGGVIGLIFAYI--CY------RQ-----HYPPLANTACHKPYVSL----RVPASLK 248

  Fly   261 VHFLAAAASASMTTTTPLDDIQDSDV 286
            ......|.||   .:.||:.|.:..|
Human   249 KEERPTADSA---PSLPLEGITEGPV 271

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
laza	NP_649391.1	PAP2_wunen	62..217	CDD:239479	54/167 (32%)
PLPP4	NP_001025230.1	PAP2_containing_1_like	37..225	CDD:239484	67/231 (29%)
		Phosphatase sequence motif I. /evidence=ECO:0000269\|PubMed:17590538	102..110		4/7 (57%)
		Phosphatase sequence motif II. /evidence=ECO:0000269\|PubMed:17590538	143..146		2/2 (100%)
		Phosphatase sequence motif III. /evidence=ECO:0000269\|PubMed:17590538	195..205		6/9 (67%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	250..271		6/23 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144666
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0671
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1621899at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3374
SonicParanoid	1	1.000	-	-		X622
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.780