DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11449 and Cfap45

DIOPT Version :9

Sequence 1:	NP_649390.1	Gene:	CG11449 / 40467	FlyBaseID:	FBgn0037162	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	NP_082248.1	Gene:	Cfap45 / 71870	MGIID:	1919120	Length:	551	Species:	Mus musculus

Alignment Length:	545	Identity:	138/545 - (25%)
Similarity:	264/545 - (48%)	Gaps:	43/545 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 AESQVQKKCNELRARARAQTAAYRPPACGFHPTATSFG---------------------SFRRPL 57
            |.|......|..|.|.|     ||..|.......:.||                     :.|:.|
Mouse     8 ASSSASTASNRSRTRTR-----YRTKAMNSEVDESLFGGVKPSSQGKSDSPIVVIHDKHAIRKTL 67

  Fly    58 CDQSAAYDQKQLKRNERDRKR-------NQGTKQVVLRAGELRRLKDQGKLETVSEKLQRIEQHE 115
            ......:..:.::...||..|       :...:.:::...|..|:|...::.|..|    :...|
Mouse    68 SALGLEHKTETIQLITRDMVRELIVPTEDPSGESLIISPEEFERIKWASQVLTKEE----LNARE 128

  Fly   116 EEHRKQLQ-MVEETRQRFKAIDEAKGVGASESRSTLLSEILEEK-ESVLSRAFLARQEQEQEVKQ 178
            :..:|:.: ::|....|.|.:.:.:....:..:.:.|.|:..|: :::|.||...|.|||:|:|.
Mouse   129 QALKKEKEGILEAVTIRKKIMKQKEMTWNNNKKLSDLEEVARERAQNLLQRADKLRMEQEEELKD 193

  Fly   179 INRMILDAKCKAVREAQIHEKHLLSKALREDDERLARMVNERAQKALTEEDERERLEVEKRNRYA 243
            ::::||:|||.|:|:|||.||..:.|.|.|::.||..|:....:::|..:::|||...|:|.|..
Mouse   194 MSKIILNAKCHAIRDAQILEKQQIQKELDEEERRLDHMMEIDRRESLQRQEDRERKRREERVRGK 258

  Fly   244 QEIRQQLSERENVRYLEAKRVADEAKDIRRATELLRSQEEQQRAFAQLRKQRLREELQRIRDMSN 308
            :.|.:|:.:.|..|.|:|:....|.:.:....:.|:.::.|........|.:::.|::||.|.:.
Mouse   259 RHIVEQIKKNEEERSLQAEHREQEKEQMLAYLDRLQEEDLQDLERRHQEKLKMQAEIKRINDENQ 323

  Fly   309 VFKTMFSEQERLADLRVTAYMRDKQEKERQLKEMKRLAKKEFERRQQRIFTVAAEAMETRQTNDE 373
            ..|.....||||||..|..:.:.|..:|.:.:..:...::|.|:...|:..:..:|.:.:...|.
Mouse   324 RQKAEMLAQERLADQMVMEFTKKKMAREAEYEAEQEKIRREKEKEIARLRALQEKAQDYQAEQDA 388

  Fly   374 LKYLKERDRVEREYRQREKEAAIARREAERDLLEARAQQAQEMKQRLALEIAHAGEEFAKVMDRM 438
            |:..:.::..:||:|::|||.|..:.|.|..|.::|.:|....:..||:::....:||.:::...
Mouse   389 LRAKRNQEVADREWRRKEKENAQKKIETEEKLRKSRLEQVAFKEHTLAVQVQRDRDEFERILRAQ 453

  Fly   439 REEEEKQKVMDRQRDAQRQAYRQDLRQQMTDKQAE--RRRLAELEAGRVQKWLDHEKQRDVNIQQ 501
            ||:.|::|....::......:..:||:|:.:.|.:  :.|||..|.||..| .:.||:|: .|:.
Mouse   454 REQIEREKQEQEKKAKGCLQHANELRRQVRENQQKHVQNRLATFEEGRRLK-EEAEKRRE-RIED 516

  Fly   502 VINAKIAAMRDNCLPEKYLREVEKQ 526
            :...|:..:|...|||||..|||::
Mouse   517 IKKQKLEELRATGLPEKYCIEVERK 541

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11449	NP_649390.1	TPH	172..517	CDD:290579	97/346 (28%)
Cfap45	NP_082248.1	TPH	187..532	CDD:290579	97/346 (28%)
Cfap45	NP_082248.1	DUF106	<330..>385	CDD:303007	13/54 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836308
Domainoid	1	1.000	163	1.000	Domainoid score	I3963
eggNOG	1	0.900	-	-		E1_2C0KR
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H71837
Inparanoid	1	1.050	183	1.000	Inparanoid score	I3955
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0007075
OrthoInspector	1	1.000	-	-		oto93941
orthoMCL	1	0.900	-	-		OOG6_103772
Panther	1	1.100	-	-	LDO	PTHR15504
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5554
SonicParanoid	1	1.000	-	-		X5954
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.780