DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11449 and cfap45

DIOPT Version :9

Sequence 1:	NP_649390.1	Gene:	CG11449 / 40467	FlyBaseID:	FBgn0037162	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	XP_012825278.1	Gene:	cfap45 / 394876	XenbaseID:	XB-GENE-955093	Length:	544	Species:	Xenopus tropicalis

Alignment Length:	515	Identity:	133/515 - (25%)
Similarity:	249/515 - (48%)	Gaps:	37/515 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 QKKCNELRARARAQTAAYRPPACGFHPTATSFGSFRRPLCDQSAAYDQKQLKRNERDRKRNQGTK 83
            ||..|..|....|.|..|:|...   ...||  ...|.|...|.......|....:|..|.:...
Frog    51 QKNPNGRRKATSAPTRVYKPETI---QIITS--DLIRDLVVPSEDPSGMSLIMTPQDFVRVKSAA 110

  Fly    84 QVVLRAGE------LRRLKDQGKLETVSEKLQRIEQHEEEHRKQLQMVEETRQRFKAIDEAKGVG 142
            :|:.:..|      |::.|::. :|.|:|:        :.|.||.:|:.:..::...::|
Frog   111 RVLTKEEELMATQSLKKAKEEA-IEAVNER--------KNHMKQKEMLRKKNEKLSELEE----- 161

  Fly   143 ASESRSTLLSEILEEKESVLSRAFLARQEQEQEVKQINRMILDAKCKAVREAQIHEKHLLSKALR 207
                      |..:..:.:|.||...|.|||.|:|::|.:||..||.|:|:||:.||..:.|.|.
Frog   162 ----------EAQQRAQYLLQRANTLRMEQEDEIKRLNEVILHTKCHAIRDAQVLEKKQIIKELD 216

  Fly   208 EDDERLARMVNERAQKALTEEDERERLEVEKRNRYAQEIRQQLSERENVRYLEAKRVADEAKDIR 272
            .::.||.:|:....|||:..::|.|....:::.|....|.:|:.|.:..|.|..::...||:.:.
Frog   217 TEERRLDQMMEVERQKAIRMQEEVEEKRKQEKIRGKFHIIKQMEENQETRILAEEQKEQEAQQML 281

  Fly   273 RATELLRSQEEQQRAFAQLRKQRLREELQRIRDMSNVFKTMFSEQERLADLRVTAYMRDKQEKER 337
            :..:.|:.|:.::....:..:.:::.|:|:|...:...|....|||:||||||..|.:.|..:|.
Frog   282 QYLDELQMQDYEEMKRRRQEQLQVQGEIQQINAENAKKKIERKEQEKLADLRVLEYNKQKMAREA 346

  Fly   338 QLKEMKRLAKKEFERRQQRIFTVAAEAMETRQTNDELKYLKERDRVEREYRQREKEAAIARREAE 402
            :.:..::..|||.|....|:..:...|.:.|...|.|:..:.::.:||.:||:|||.|..:.|..
Frog   347 EYEAEQQRIKKEKELEVARLRALQERARDYRAEQDALRAKRNQEAMERAWRQKEKEVAQKQAEMN 411

  Fly   403 RDLLEARAQQAQEMKQRLALEIAHAGEEFAKVMDRMREEEEKQKVMDRQRDAQRQAYRQDLRQQM 467
            ..:.:.|.:|..:.:..||::......||.:|:...|...||::....::::|...:..:||:|:
Frog   412 SMMKQTRMEQIAQKEHCLAVQAQRDRSEFNRVLREQRMMIEKERKELEEKNSQLMKHAAELRRQV 476

  Fly   468 TDKQAERRRLAELEAGRVQKWLDHE-KQRDVNIQQVINAKIAAMRDNCLPEKYLREVEKQ 526
            .:.: :::.||.::.....|.||.| :||...:.::...|:..:|...||:|||..|.::
Frog   477 RENE-QKQVLARVDYFEEGKRLDEEARQRRARLDELKQKKLKELRTAGLPDKYLSMVTRK 535

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11449	NP_649390.1	TPH	172..517	CDD:290579	94/345 (27%)
cfap45	XP_012825278.1	TPH	178..525	CDD:372768	95/347 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	155	1.000	Domainoid score	I4192
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H71837
Inparanoid	1	1.050	178	1.000	Inparanoid score	I3918
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1428717at2759
OrthoFinder	1	1.000	-	-		FOG0007075
OrthoInspector	1	1.000	-	-		oto104164
Panther	1	1.100	-	-	LDO	PTHR15504
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5554
SonicParanoid	1	1.000	-	-		X5954
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	11.100