DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11449 and Cfap45

DIOPT Version :9

Sequence 1:	NP_649390.1	Gene:	CG11449 / 40467	FlyBaseID:	FBgn0037162	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	NP_001020053.2	Gene:	Cfap45 / 304984	RGDID:	1561559	Length:	551	Species:	Rattus norvegicus

Alignment Length:	547	Identity:	142/547 - (25%)
Similarity:	260/547 - (47%)	Gaps:	47/547 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 AESQVQKKCNELRARARAQTAAYRPPACGFHPTATSFGSFRRP---LCDQSAAY--DQKQLKRN- 72
            |.|.:....|..|.|.|     ||..|.......:.||..:.|   .||.....  |:..:::.
  Rat     8 ASSSISTASNRSRNRTR-----YRTKAMNSEVDESLFGGVKPPPQDKCDSPIVVIRDKHAIRKTL 67

  Fly    73 ---------------ERDRKR-------NQGTKQVVLRAGELRRLKDQGKLETVSEKLQRIEQHE 115
                           .||..|       :...:.:::...|..|:|....:.|..|    :...|
  Rat    68 SALGLDHKPETIQLITRDMVRELIVPTEDPSGESLIISPEEFERIKWASHVLTKEE----LNARE 128

  Fly   116 EEHRKQLQMVEETRQRFKAIDEAKGVGASESRSTLLSEILE----EKESVLSRAFLARQEQEQEV 176
            :..:|:.:.:.:.....|.|.:.|.:..:.::.  ||::.|    ..:::|.||...|.|||:|:
  Rat   129 QAFKKEKEAILDAVTVRKKIMKQKEMAWNNNKK--LSDLEEVARARAQNLLQRANNLRMEQEEEL 191

  Fly   177 KQINRMILDAKCKAVREAQIHEKHLLSKALREDDERLARMVNERAQKALTEEDERERLEVEKRNR 241
            |.::::||:|||.|:|:|||.||..:.|.|.|::.||..|:....|::|..:::|||...|:|.|
  Rat   192 KDMSKIILNAKCHAIRDAQILEKQQIKKELDEEERRLDHMMEIDRQQSLQRQEDRERRRREERIR 256

  Fly   242 YAQEIRQQLSERENVRYLEAKRVADEAKDIRRATELLRSQEEQQRAFAQLRKQRLREELQRIRDM 306
            ..:.|.:|:.:.|..|.|:|:....|.:.:....|.|:.::.|........|.:::.|::||.|.
  Rat   257 GKRHIVEQMKKNEEERSLQAEHREQEKEQMLAYLERLQEEDLQDLERRHQEKLKMQAEIKRINDE 321

  Fly   307 SNVFKTMFSEQERLADLRVTAYMRDKQEKERQLKEMKRLAKKEFERRQQRIFTVAAEAMETRQTN 371
            :...|.....||:|||..|..:.:.|..:|.:.:..:...:||.|:...|:..:..:|.:.|...
  Rat   322 NQRQKAEMLAQEKLADQMVMEFTKKKMAREAEFEAEQEKIRKEKEKEIARLRALQEKAQDYRAEQ 386

  Fly   372 DELKYLKERDRVEREYRQREKEAAIARREAERDLLEARAQQAQEMKQRLALEIAHAGEEFAKVMD 436
            |.|:..:.::..:||:|.:|||.|..:.|.|..|.::|..|....:..||:::....:||.:::.
  Rat   387 DALRAKRNQEVADREWRLKEKENAQKKIETEEKLRKSRLDQVAFKEHTLAVQVQRDRDEFERILR 451

  Fly   437 RMREEEEKQKVMDRQRDAQRQAYRQDLRQQMTDKQAE--RRRLAELEAGRVQKWLDHEKQRDVNI 499
            ..||:.||:|....::.|....:..:||:|:.:.|.:  :.|||..|.||..|  :..::|...|
  Rat   452 AQREQIEKEKREQEKKAAGCLQHANELRRQVRENQQKQVQNRLATFEEGRRLK--EEAQKRRERI 514

  Fly   500 QQVINAKIAAMRDNCLPEKYLREVEKQ 526
            :.:...|:..:|...|||||..|.|::
  Rat   515 EDIKKQKLEELRATGLPEKYCIEAERK 541

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11449	NP_649390.1	TPH	172..517	CDD:290579	100/346 (29%)
Cfap45	NP_001020053.2	TPH	187..532	CDD:290579	100/346 (29%)
Cfap45	NP_001020053.2	GBP_C	<263..338	CDD:303769	19/74 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166339973
Domainoid	1	1.000	169	1.000	Domainoid score	I3716
eggNOG	1	0.900	-	-		E1_2C0KR
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H71837
Inparanoid	1	1.050	183	1.000	Inparanoid score	I3871
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1428717at2759
OrthoFinder	1	1.000	-	-		FOG0007075
OrthoInspector	1	1.000	-	-		oto97473
orthoMCL	1	0.900	-	-		OOG6_103772
Panther	1	1.100	-	-	LDO	PTHR15504
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X5954
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.760