DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ten-m and TENM2

DIOPT Version :9

Sequence 1:NP_001262211.1 Gene:Ten-m / 40464 FlyBaseID:FBgn0004449 Length:3349 Species:Drosophila melanogaster
Sequence 2:NP_001382389.1 Gene:TENM2 / 57451 HGNCID:29943 Length:2774 Species:Homo sapiens


Alignment Length:2963 Identity:919/2963 - (31%)
Similarity:1443/2963 - (48%) Gaps:482/2963 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly   584 TTVRSDTDDIVEINTPPSQTAQRTFAAVSHQPAIEHDFQIKGTDAGGLQTEKPATDDINNERD-- 646
            |:...|::| ..:.|..|.::..|..|..|...:.:..::              ||.|:.|.|  
Human    23 TSSSLDSED-CRVPTQKSYSSSETLKAYDHDSRMHYGNRV--------------TDLIHRESDEF 72

  Fly   647 ------------------------------LADNYEV----DSKEPTSPGTPPQ------GKVSQ 671
                                          |...|.:    |:...|..|..|:      |:..:
Human    73 PRQGTNFTLAELGICEPSPHRSGYCSDMGILHQGYSLSTGSDADSDTEGGMSPEHAIRLWGRGIK 137

  Fly   672 QTGKASLQSLQSESDLMMNDASHYEDIDIVKLDGLTISHEEEIYKTADKEN-------MAPKNQP 729
            ....:.|.|.::.:                    ||::..:...| :|.||       .:|...|
Human   138 SRRSSGLSSRENSA--------------------LTLTDSDNENK-SDDENGRPIPPTSSPSLLP 181

  Fly   730 SQHIDRSQN-----------EVLKGHQQGDEKQPQLEPLKPYVSERVDLPGKRIFLNLTIATDEG 783
            |..:..|.|           :....||..|....:......|:......|.:        |:..|
Human   182 SAQLPSSHNPPPVSCQMPLLDSNTSHQIMDTNPDEEFSPNSYLLRACSGPQQ--------ASSSG 238

  Fly   784 ---SDSVYTLHVEVPTGGGPHFIKEVLTHEKPTAQA---------DSCVPEPPPRMPDCPCSCLP 836
               ..|..||...:|.   ||  ...|:|...:|.:         .|.:..|.|    .|.....
Human   239 PPNHHSQSTLRPPLPP---PH--NHTLSHHHSSANSLNRNSLTNRRSQIHAPAP----APNDLAT 294

  Fly   837 PPAPIYLDDTVDIDSAPPAKT----VTTSTISAPINPFHSEEEDDEDGVRDEEQTPSSSTATNLP 897
            .|..:.|.|:..::|..|.:|    ..||:.|.|:                     .||::...|
Human   295 TPESVQLQDSWVLNSNVPLETRHFLFKTSSGSTPL---------------------FSSSSPGYP 338

  Fly   898 STEIDNHIAAFTEPAVGAGGVPFACPDVMPVLILEGARTFPARSF-------------------- 942
            .|.    ...:|.|           |.::|      ..||..::|                    
Human   339 LTS----GTVYTPP-----------PRLLP------RNTFSRKAFKLKKPSKYCSWKCAALSAIA 382

  Fly   943 -------------------------PPDGTTF--------------------------------- 949
                                     |.||.||                                 
Human   383 AALLLAILLAYFIAMHLLGLNWQLQPADGHTFNNGIRTGLPGNDDVATMPSGGKVPWSLKNSSID 447

  Fly   950 -GQITLGQKLTKEIQPYSYWNMQFYQSEPAYVKFDYTIPRGASIGVYGRRNALPTHTQYHFKEVL 1013
             |:..:|:::|:|:.|..:|..|.:.|:|.::||:.::.:.|..|||.||...|:|.||.|.|.|
Human   448 SGEAEVGRRVTQEVPPGVFWRSQIHISQPQFLKFNISLGKDALFGVYIRRGLPPSHAQYDFMERL 512

  Fly  1014 SG-----FSASTRTARAAHLSITREV--TRYMEPGHWFVSLYNDDGDVQELTFYAAVAEDMTQNC 1071
            .|     ...|.|..|:....:..|.  .:|::.|.|.::.|||..| :|:..:..|..|..|:|
Human   513 DGKEKWSVVESPRERRSIQTLVQNEAVFVQYLDVGLWHLAFYNDGKD-KEMVSFNTVVLDSVQDC 576

  Fly  1072 PNGCSGNGQCLLGHCQCNPGFGGDDCSESVCPVLCSQHGEYTNGECICNPGWKGKECSLRHDECE 1136
            |..|.|||:|:.|.|.|.|||.|.||:::.||||||.:|:|:.|.|.|..||||.||.:..::|.
Human   577 PRNCHGNGECVSGVCHCFPGFLGADCAKAACPVLCSGNGQYSKGTCQCYSGWKGAECDVPMNQCI 641

  Fly  1137 VADCSGHGHCVSGKCQCMRGYKGKFCEEVDCPHPNCSGHGFCADGTCICKKGWKGPDCATMDQDA 1201
            ...|.|||.|:.|.|.|..||||:.||||||..|.||.||.|.:|.|:|..||.|.:|   :...
Human   642 DPSCGGHGSCIDGNCVCSAGYKGEHCEEVDCLDPTCSSHGVCVNGECLCSPGWGGLNC---ELAR 703

  Fly  1202 LQCLPDCSGHGTFDLDTQTCTCEAKWSGDDCSKELCDLDCGQHGRCEGDACACDPEWGGEYCNTR 1266
            :||...||||||:..||..|:|:..|.|.|||.|:|.:|||.||.|.|.||.|:..|.|..|:.|
Human   704 VQCPDQCSGHGTYLPDTGLCSCDPNWMGPDCSVEVCSVDCGTHGVCIGGACRCEEGWTGAACDQR 768

  Fly  1267 LCDVRCNEHGQCKNGTCLCVTGWNGKHCTI---------EGCPNSCAGHGQCRVSGEGQWECRCY 1322
            :|..||.|||.||:|.|.|..||||:||||         :|||:.|.|:|:|.: |:..|:|.|.
Human   769 VCHPRCIEHGTCKDGKCECREGWNGEHCTIGRQTAGTETDGCPDLCNGNGRCTL-GQNSWQCVCQ 832

  Fly  1323 EGWDGPDCGIALELNCGDSKDNDKDGLVDCEDPECCASHVCKTSQLCVSAPKPIDVLLRKQP--P 1385
            .||.||.|.:|:|.:|.|:|||:.||||||.||:||....|:.|.||..:..|:|::.:.|.  |
Human   833 TGWRGPGCNVAMETSCADNKDNEGDGLVDCLDPDCCLQSACQNSLLCRGSRDPLDIIQQGQTDWP 897

  Fly  1386 AITASFFERMKFLIDESSLQNYAKLETFNESIFWNYFNASRSAVIRGRVVTSLGMGLVGVRVSTT 1450
            |: .||::|:|.|..:.|.....     .|    |.||:|..::|||:|||:.|..||||.||..
Human   898 AV-KSFYDRIKLLAGKDSTHIIP-----GE----NPFNSSLVSLIRGQVVTTDGTPLVGVNVSFV 952

  Fly  1451 TLLE-GFTLTRDDGWFDLMVNGGGAVTLQFGRAPFRPQSRIVQVPWNEVVIIDLVVMSMSEEKGL 1514
            ...: |:|:||.||.|||:.|||.::||.|.||||..|.|.|.:|||....:|.:||. :||..:
Human   953 KYPKYGYTITRQDGTFDLIANGGASLTLHFERAPFMSQERTVWLPWNSFYAMDTLVMK-TEENSI 1016

  Fly  1515 AVTTTHTCFAHDYDLMKPVVLASWKHGFQGACPDRSAILAESQVIQESLQIPGTGLNLVYHSSRA 1579
            .     :|....:....|::::|....|..|.|.::.|:.|:||:.|.:::||:.:.|.|.|||.
Human  1017 P-----SCDLSGFVRPDPIIISSPLSTFFSAAPGQNPIVPETQVLHEEIELPGSNVKLRYLSSRT 1076

  Fly  1580 AGYLSTIKLQLTPDVIPTSLHLIHLRITIEGILFERIFEADPGIKFTYAWNRLNIYRQRVYGVTT 1644
            |||.|.:|:.:|...:|.:|..:||.:.:||.||::.|:|.|.:.:|:.|::.:.|.|||||::.
Human  1077 AGYKSLLKITMTQSTVPLNLIRVHLMVAVEGHLFQKSFQASPNLAYTFIWDKTDAYGQRVYGLSD 1141

  Fly  1645 AVVKVGYQYTDCTD-IVWDIQTTKLSGHDMSISEVGGWNLDIHHRYNFHEGILQKGDGSNIYLRN 1708
            |||.||::|..|.. |:|:.:|..|.|.::..|.:|||:||.||..|...|||.||.|.|.:|..
Human  1142 AVVSVGFEYETCPSLILWEKRTALLQGFELDPSNLGGWSLDKHHILNVKSGILHKGTGENQFLTQ 1206

  Fly  1709 KPRIILTTMGDGHQRPLECPDCDGQATKQRLLAPVALAAAPDGSLFVGDFNYIRRIMTDGSIRTV 1773
            :|.||.:.||:|.:|.:.||.|:|.|...:||||||||...||||:||||||||||....::.::
Human  1207 QPAIITSIMGNGRRRSISCPSCNGLAEGNKLLAPVALAVGIDGSLYVGDFNYIRRIFPSRNVTSI 1271

  Fly  1774 VKL------NATRVSYRYHMALSPLDGTLYVSDPESHQIIRVRDTNDYSQPELNWEAVVGSGERC 1832
            ::|      ::...:::|::|:.|:.|:|||||..|.:|.||:..:.......|.|.|.|:||:|
Human  1272 LELRNKEFKHSNNPAHKYYLAVDPVSGSLYVSDTNSRRIYRVKSLSGTKDLAGNSEVVAGTGEQC 1336

  Fly  1833 LPGDEAHCGDGALAKDAKLAYPKGIAISSDNILYFADGTNIRMVDRDGIVSTLIGNHMHKSHWKP 1897
            ||.|||.||||..|.||.|..|:|||:..:.::||.|.|.||.||::||:|||:|:: ..:..:|
Human  1337 LPFDEARCGDGGKAIDATLMSPRGIAVDKNGLMYFVDATMIRKVDQNGIISTLLGSN-DLTAVRP 1400

  Fly  1898 IPCEGTLKLEEMHLRWPTELAVSPMDNTLHIIDDHMILRMTPDGRVRVISGRPLHCATASTAYD- 1961
            :.|:.::.:.::.|.|||:|||:||||:|:::::::|||:|.:.:|.:|:|||:||......|. 
Human  1401 LSCDSSMDVAQVRLEWPTDLAVNPMDNSLYVLENNVILRITENHQVSIIAGRPMHCQVPGIDYSL 1465

  Fly  1962 TDLATHATLVMPQSIAFGPLGELYVAESDSQRINRVRVIGTDGRIAPFAGAESKCNCL-ERGCDC 2025
            :.||.|:.|....:||....|.||:.|:|.::|||:|.:.|:|.|...|||.|.|:|. :..|:|
Human  1466 SKLAIHSALESASAIAISHTGVLYITETDEKKINRLRQVTTNGEICLLAGAASDCDCKNDVNCNC 1530

  Fly  2026 FEAEHYLATSAKFNTIAALAVTPDSHVHIADQANYRIRSVMSSIPEASPSREYEIYAPDMQEIYI 2090
            :..:...||.|..|:.::|||.||..::|||..|.|||:|..:.|..:...:||..:|..||:|:
Human  1531 YSGDDAYATDAILNSPSSLAVAPDGTIYIADLGNIRIRAVSKNKPVLNAFNQYEAASPGEQELYV 1595

  Fly  2091 FNRFGQHVSTRNILTGETTYVFTYNVNTSNGKLSTVTDAAGNKVFLLRDYTSQVNSIENTKGQKC 2155
            ||..|.|..|.:::|||..|.|||:           ||             :.|..:.:..|...
Human  1596 FNADGIHQYTVSLVTGEYLYNFTYS-----------TD-------------NDVTELIDNNGNSL 1636

  Fly  2156 RLRMTRMKMLHELSTPDNYNVT---------------------YEYHGPTGLLRTKLDSTGRSYV 2199
            ::|.....|...|..|||..:|                     ..|.|.||||.||.|.||.:..
Human  1637 KIRRDSSGMPRHLLMPDNQIITLTVGTNGGLKVVSTQNLELGLMTYDGNTGLLATKSDETGWTTF 1701

  Fly  2200 YNYDEFGRLTSAVTPTGRVIELSFDLSVKGAQVKVSENAQKEMSLLIQGATVIVRNGAAESRTTV 2264
            |:||..||||:...|||.|..|..::. |...:.: ||:.::     ...|||....:.|:..||
Human  1702 YDYDHEGRLTNVTRPTGVVTSLHREME-KSITIDI-ENSNRD-----DDVTVITNLSSVEASYTV 1759

  Fly  2265 DMD-----------GSTTSITPWGHNLQMEVAPYTILAEQSPLLGE---SYPVPAKQRTEIAGDL 2315
            ..|           |:...:...|..:.....|:.:....:|.:|.   |.|:.         :.
Human  1760 VQDQVRNSYQLCNNGTLRVMYANGMGISFHSEPHVLAGTITPTIGRCNISLPME---------NG 1815

  Fly  2316 ANRFEWRYFVRRQQPLQAGKQSKGPPRPVTEVGRKLRVNGDNVLTLEYDRETQSVVVMVDDKQEL 2380
            .|..|||  :|::       |.||   .||..||||||:|.|:|:::|||..::..:..|.::..
Human  1816 LNSIEWR--LRKE-------QIKG---KVTIFGRKLRVHGRNLLSIDYDRNIRTEKIYDDHRKFT 1868

  Fly  2381 LNVTYDRTSRPISFRPQSGDYADVDLEYDRFGRLVSWKWGVLQEAYSFDRNGRLNEIKYGDGSTM 2445
            |.:.||:..||..:.|.|| .|.|::.|...|||...:.|.:.|....|:.||:....:.||...
Human  1869 LRIIYDQVGRPFLWLPSSG-LAAVNVSYFFNGRLAGLQRGAMSERTDIDKQGRIVSRMFADGKVW 1932

  Fly  2446 VYAFKDMFGSLPLKVTTPRRSDYLLQYDDAGALQSLTTPRGHIHAFSLQTSLGFFKYQYYSPINR 2510
            .|::.|.  |:.|.:.:.|:  |:.:||.:..|.::|.|....|:.|..||:|:.:..|..|.:.
Human  1933 SYSYLDK--SMVLLLQSQRQ--YIFEYDSSDRLLAVTMPSVARHSMSTHTSIGYIRNIYNPPESN 1993

  Fly  2511 HPFEILYNDEGQILAKIHPHQSGKVAFVHDTAGRLETILAGLSSTHYTYQDTTSLVKSVEVQEPG 2575
            ......|:|:|:||.........:|.:.:....:|..|:...::..:.|.:||.::|.|.:|..|
Human  1994 ASVIFDYSDDGRILKTSFLGTGRQVFYKYGKLSKLSEIVYDSTAVTFGYDETTGVLKMVNLQSGG 2058

  Fly  2576 FELRREFKYHAGILKDEKLRFGSKNSLASARYKYAY-DGNARLSGIEMAIDDKELPTTRYKYSQN 2639
            |.....:: ..|.|.|:::...|:..:.:||:.|.| |.:.|::.|:..|.:..||...|:|.:.
Human  2059 FSCTIRYR-KIGPLVDKQIYRFSEEGMVNARFDYTYHDNSFRIASIKPVISETPLPVDLYRYDEI 2122

  Fly  2640 LGQLE-------VVQDLKITRNAFNRTVIQDSAKQFFAIVDYDQHGRVKSVLMNVKNIDVFRLEL 2697
            .|::|       :..|:    |....|.:...:|.|      |.|||:|.|...:....::.:.:
Human  2123 SGKVEHFGKFGVIYYDI----NQIITTAVMTLSKHF------DTHGRIKEVQYEMFRSLMYWMTV 2177

  Fly  2698 DYDLRNRIKSQKTTFGRSTAFDKINYNADG----HVVEVLGTNNWKYLFDENGNTVGVVDQGEKF 2758
            .||...|:..::...|......|..|:.||    ..|.|.....|:|.:|.||| :.:::.|...
Human  2178 QYDSMGRVIKRELKLGPYANTTKYTYDYDGDGQLQSVAVNDRPTWRYSYDLNGN-LHLLNPGNSV 2241

  Fly  2759 N---LGYDIGDRVIKVGDVEFNNYDARGFVVKRGEQKYRYNNRGQLIHSFERERFQSW---YYYD 2817
            .   |.||:.||:.::|||:: ..|..|::.:||...:.||::|.|..::.:.  ..|   |.||
Human  2242 RLMPLRYDLRDRITRLGDVQY-KIDDDGYLCQRGSDIFEYNSKGLLTRAYNKA--SGWSVQYRYD 2303

  Fly  2818 DRSRLVAWHDNKGNTTQYYYANPRTPHLVTHVHFPKISRTMKLFYDDRDMLIALEHED-QRYYVA 2881
            ...|..::..|.|:..||:|::...|..:|||:....|....|:||.:..|.|:|... :.||||
Human  2304 GVGRRASYKTNLGHHLQYFYSDLHNPTRITHVYNHSNSEITSLYYDLQGHLFAMESSSGEEYYVA 2368

  Fly  2882 TDQNGSPLAFFDQNGSIVKEMKRTPFGRIIKDTKPEFFVPIDFHGGLIDPHTKLVYTEQRQYDPH 2946
            :|..|:|||.|..||.::|:::.|.:|.|..|:.|:|.:.|.|||||.||.||||:..||.||..
Human  2369 SDNTGTPLAVFSINGLMIKQLQYTAYGEIYYDSNPDFQMVIGFHGGLYDPLTKLVHFTQRDYDVL 2433

  Fly  2947 VGQWMTP---LWETLATEMSHPTDVFIYRYHNNDPINPNKP-QNYMIDLDSWLQLFGYDLNNMQS 3007
            .|:|.:|   :|:.:..|   |....:|.:.:|:|::.... :||:.|:.|||.:||:.|:|:..
Human  2434 AGRWTSPDYTMWKNVGKE---PAPFNLYMFKSNNPLSSELDLKNYVTDVKSWLVMFGFQLSNIIP 2495

  Fly  3008 SRYTKLAQYTPQASIKSNTLAPDFG-VISGLECIVEKTSEKFSDFDFVPKPLLKMEPKM--RNLL 3069
            ........:.|.....|.:.|.:.| :|:|::...|:.::.|          :.:|.::  :.|.
Human  2496 GFPRAKMYFVPPPYELSESQASENGQLITGVQQTTERHNQAF----------MALEGQVITKKLH 2550

  Fly  3070 PRVSYRRG--------VFGEGVLLSRIGGRALVSVVDGSNSVVQD---VVSSVFNNSYFLD-LHF 3122
            ..:..:.|        :.|:|::.:...||    |..|.:|:..:   .|:||.||:|:|| :|:
Human  2551 ASIREKAGHWFATTTPIIGKGIMFAIKEGR----VTTGVSSIASEDSRKVASVLNNAYYLDKMHY 2611

  Fly  3123 SIHDQDVFYFVKDNVLKLRDDNEELRRLGGMFNISTHEISDHGGSAAKELRLHG----------- 3176
            ||..:|..|||     |:...:.:|..||........|...:...:...|.::|           
Human  2612 SIEGKDTHYFV-----KIGSADGDLVTLGTTIGRKVLESGVNVTVSQPTLLVNGRTRRFTNIEFQ 2671

  Fly  3177 -PDAVVIIKYGVDP---EQERHRILKHAHKRAVERAWELEKQLVAAGFQGRGDWTEEEKEELVQH 3237
             ...::.|:||:.|   ::|:.|:|..|.:||:..||..|:|....|.:|...|||.||::|:..
Human  2672 YSTLLLSIRYGLTPDTLDEEKARVLDQARQRALGTAWAKEQQKARDGREGSRLWTEGEKQQLLST 2736

  Fly  3238 GDVDGWNGIDIHSIHKYPQLADDPGNVAFQRDAKRKRR 3275
            |.|.|:.|..:..:.:||:|||...|:.|.|..:..:|
Human  2737 GRVQGYEGYYVLPVEQYPELADSSSNIQFLRQNEMGKR 2774

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ten-mNP_001262211.1 TNFRSF 1069..1198 CDD:304602 66/128 (52%)
CRD2 1106..1151 CDD:276900 20/44 (45%)
EGF_2 1139..1162 CDD:285248 12/22 (55%)
Keratin_B2 1162..1330 CDD:279797 86/176 (49%)
EGF_2 1167..1194 CDD:285248 13/26 (50%)
DUF3844 1171..>1235 CDD:289707 29/63 (46%)
EGF_2 <1272..1294 CDD:285248 13/21 (62%)
NHL 1750..2065 CDD:302697 134/322 (42%)
NHL repeat 1784..1830 CDD:271320 17/45 (38%)
NHL repeat 1854..1888 CDD:271320 17/33 (52%)
NHL repeat 1911..1950 CDD:271320 19/38 (50%)
NHL repeat 1972..2005 CDD:271320 12/32 (38%)
NHL repeat 2039..2065 CDD:271320 13/25 (52%)
RHS_repeat 2183..2218 CDD:283287 19/34 (56%)
RhsA 2347..3020 CDD:225750 206/695 (30%)
YD_repeat_2x 2795..2836 CDD:273728 12/43 (28%)
Rhs_assc_core 2905..2980 CDD:274730 31/77 (40%)
Tox-GHH 3193..3268 CDD:292269 28/74 (38%)
TENM2NP_001382389.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 111..271 34/193 (18%)
NHL 1 1272..1316 14/43 (33%)
NHL 2 1342..1386 22/43 (51%)
NHL 3 1401..1452 19/50 (38%)
NHL 4 1474..1501 10/26 (38%)
NHL 5 1530..1573 18/42 (43%)
YD 1 1583..1602 9/18 (50%)
YD 2 1619..1639 5/43 (12%)
YD 3 1682..1701 11/18 (61%)
YD 4 1702..1724 11/21 (52%)
YD 5 1895..1914 6/18 (33%)
YD 6 1936..1954 5/21 (24%)
YD 7 1955..1975 6/19 (32%)
YD 8 1982..1999 2/16 (13%)
YD 9 2000..2021 6/20 (30%)
YD 10 2022..2039 2/16 (13%)
YD 11 2042..2062 8/19 (42%)
YD 12 2065..2085 4/20 (20%)
YD 13 2093..2113 5/19 (26%)
YD 14 2119..2136 3/16 (19%)
YD 15 2137..2163 10/35 (29%)
YD 16 2165..2178 0/12 (0%)
YD 17 2179..2202 5/22 (23%)
YD 18 2205..2225 5/19 (26%)
YD 19 2226..2246 5/20 (25%)
YD 20 2248..2268 8/20 (40%)
YD 21 2280..2300 5/21 (24%)
YD 22 2302..2322 6/19 (32%)
YD 23 2348..2389 18/40 (45%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165147779
Domainoid 1 1.000 72 1.000 Domainoid score I9322
eggNOG 1 0.900 - - E1_KOG1225
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H22672
Inparanoid 1 1.050 1457 1.000 Inparanoid score I111
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG52630
OrthoDB 1 1.010 - - D5817at33208
OrthoFinder 1 1.000 - - FOG0000741
OrthoInspector 1 1.000 - - otm41291
orthoMCL 1 0.900 - - OOG6_100953
Panther 1 1.100 - - O PTHR11219
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X442
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1514.770

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