DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ten-m and tenm2b

DIOPT Version :9

Sequence 1:	NP_001262211.1	Gene:	Ten-m / 40464	FlyBaseID:	FBgn0004449	Length:	3349	Species:	Drosophila melanogaster
Sequence 2:	XP_021324871.1	Gene:	tenm2b / 568845	ZFINID:	ZDB-GENE-060503-100	Length:	2703	Species:	Danio rerio

Alignment Length:	2917	Identity:	931/2917 - (31%)
Similarity:	1456/2917 - (49%)	Gaps:	369/2917 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   512 LVNKRRKYDHGTVEAE-HIKHEEEEEED----EQKLERHEAIGMATELTTESETSTLPAVIDDDN 571
            |.::||....||...| |......:.|:    .||              :.|.:.||.|.    .
Zfish     3 LKDRRRSLTRGTSGKEMHYATSSLDSENCHIVSQK--------------SYSSSKTLKAY----Q 49

  Fly   572 QSDNSSSGPTPETTVRSDTDDIVEINTPPSQTAQRTFAAVSHQPAIEHDFQIKGTDAGGLQTEKP 636
            |......|......|..:|::.|       :.|....|.|:....:...|.:  .|.|..:...|
Zfish    50 QDGRLRYGACVAELVHQETEEYV-------RQAYVELAPVAVGYYLSGSFAL--ADLGMCEPPPP 105

  Fly   637 ATDDINNERDLADNYEVDSKEPTSPGTPPQGKVSQQTGKA--SLQSLQSESDLMMNDASHYEDID 699
            ::...::...|.|.|.:::  .:...:.|:|.::.:....  |.|.|:|.....::...|
Zfish   106 SSVYCSDISLLQDRYSLNA--VSDADSDPEGVMTPERAVQLWSRQPLKSRRSSCLSSPDH----- 163

  Fly   700 IVKLDGLTISHEEEIYKTADKENMA-----------PKNQP-SQHIDRSQNEVLKGHQQGDEKQP 752
                ..||::..|..:|| |:|:.|           |...| :.|...|.|.:.:..|.|...|.
Zfish   164 ----SVLTLTDSENEHKT-DEESGASSHHSQTSLRPPLPPPHNHHHQSSANSLNRSAQAGRRNQQ 223

  Fly   753 QLEPLK------PYVSERVDLPGKRIFLNLTIATDEGSDSVYTLHVEVPTGGGPHFIKEVLTHEK 811
            ...|..      |...|.|.|                .|| :.|:..||. ...||:.:..:...
Zfish   224 SHAPAAVAPPDGPSTPESVQL----------------QDS-WALNSSVPL-ETRHFLFKTPSGST 270

  Fly   812 PTAQADS--------CVPEPPPRMPDCPCSCLPPPAPIYLDDTVDIDSAPPAKTVTTSTISAPIN 868
            |...:.|        .|..||||:                         .|..|.:.|:...
Zfish   271 PLFSSSSPGYPLTGGTVYSPPPRL-------------------------LPRNTFSRSSFKL--- 307

  Fly   869 PFHSEEEDDEDGVRDEEQTPS----------SSTATNLPSTEIDNHIAAF-----------TEPA 912
                             :.||          |:.|..:....:.:::.|.           ||..
Zfish   308 -----------------KKPSKYCSWKCAAVSAIAAAVLLAVLLSYVIALNLLGLNWRLKPTEGH 355

  Fly   913 VGAGGVPFACPDVMPVLILEGARTFPARSFPP-----DGTTFGQITLGQKLTKEIQPYSYWNMQF 972
            :...|:..:.|.:..|      .|.|:....|     ...:.|::.|||::::::.|..:|....
Zfish   356 LVNTGLSMSIPGIGDV------ATVPSGGRGPWVLKNSSISSGELELGQRVSQDVPPGVFWRSLL 414

  Fly   973 YQSEPAYVKFDYTIPRGASIGVYGRRNALPTHTQYHFKEVLSG-----FSASTRTARAAHLSITR 1032
            :..:|.::||:.::.:.|..|||.|:...|:|.||.|.|.|.|     ...|.|..|:....:..
Zfish   415 HLRQPHFLKFNISLGKDALFGVYMRKGLPPSHAQYDFMERLDGKEKWSVIESPRERRSIQTVVQN 479

  Fly  1033 EV--TRYMEPGHWFVSLYNDDGDVQELTFYAAVAEDMTQNCPNGCSGNGQCLLGHCQCNPGFGGD 1095
            |.  .:|::||.|.::.|| ||..:|...::.||.|..:.|...|.|||:|:.|.|.|.|||.|.
Zfish   480 EAIFVQYLDPGTWHLAFYN-DGKEKEPVSFSTVALDSVEECSQNCHGNGECMSGACHCFPGFHGS 543

  Fly  1096 DCSESVCPVLCSQHGEYTNGECICNPGWKGKECSLRHDECEVADCSGHGHCVSGKCQCMRGYKGK 1160
            |||:..||||||.:|:|:.|.|:|..||||.||.:...:|....|.|||.|..|.|.|..||:|:
Zfish   544 DCSKVACPVLCSGNGQYSKGVCMCYSGWKGLECDVPQGQCVDPSCGGHGTCAQGSCTCEAGYRGE 608

  Fly  1161 FCEEVDCPHPNCSGHGFCADGTCICKKGWKGPDCATMDQDALQCLPDCSGHGTFDLDTQTCTCEA 1225
            .||||||..|.|||||.|..|.|.||.||.||.|   |....||...|:|||.:..||..|:|:.
Zfish   609 SCEEVDCLDPTCSGHGSCVSGQCHCKPGWSGPLC---DVSRAQCPDQCNGHGVYSPDTGLCSCDP 670

  Fly  1226 KWSGDDCSKELCDLDCGQHGRCEGDACACDPEWGGEYCNTRLCDVRCNEHGQCKNGTCLCVTGWN 1290
            .|.|.|||.|:|..|||.||.|.|..|.|:..|.|..|:.|||:.:|.:||.|::|.|.|..|||
Zfish   671 NWMGPDCSTEVCSADCGSHGVCVGGVCHCEEGWTGTSCDQRLCNPQCVKHGTCRDGKCQCEQGWN 735

  Fly  1291 GKHCTIEGCPNSCAGHGQCRVSGEGQWECRCYEGWDGPDCGIALELNCGDSKDNDKDGLVDCEDP 1355
            |:||||:|||..|.|:||| :.|:..|.|.|:.||.||.|.:|:|.:|.|:|||:.||||||.||
Zfish   736 GEHCTIDGCPGLCNGNGQC-IMGQNSWHCECHTGWRGPGCSVAMETSCNDNKDNEGDGLVDCMDP 799

  Fly  1356 ECCASHVCKTSQLCVSAPKPIDVLLRKQPPA-ITASFFERMKFLIDESSLQNYAKLETFNESIFW 1419
            :||....|.|:.||..:..|:.|:.:.|... ...||::|:|.|:.:.|......:
Zfish   800 DCCTQSSCMTNPLCRGSRDPLQVIQQSQSEVQKVPSFYDRIKMLVGKDSTHIIPGI--------- 855

  Fly  1420 NYFNASRSAVIRGRVVTSLGMGLVGVRVSTTTLLE----GFTLTRDDGWFDLMVNGGGAVTLQFG 1480
            |.||||.:::|||:|:||.|..||||.|   |.::    |.|:||.||.|||:.||||::.|:|.
Zfish   856 NPFNASLASLIRGQVLTSDGTPLVGVNV---TFVKYPHYGHTMTRQDGTFDLVANGGGSLALRFE 917

  Fly  1481 RAPFRPQSRIVQVPWNEVVIIDLVVMSMSEEKGLAVTTTHTCFAHDYDLMKPVVLASWKHGFQGA 1545
            ||||:.|.|.|.:|||....:|.:|: .:|||     .|..|....:....|:||.|....|..:
Zfish   918 RAPFQSQERTVWLPWNRFYAMDTLVL-QTEEK-----PTARCDLSGFVRPDPIVLPSPLSSFFSS 976

  Fly  1546 CPDRSAILAESQVIQESLQIPGTGLNLVYHSSRAAGYLSTIKLQLTPDVIPTSLHLIHLRITIEG 1610
            .|....||.||||:.|.::||||.|.|.|.|||.:||||.:|:.:||.::|.||..:||.:.:||
Zfish   977 NPSERHILPESQVLHEQVEIPGTSLKLCYLSSRTSGYLSLLKVIMTPALVPLSLAKVHLMVAVEG 1041

  Fly  1611 ILFERIFEADPGIKFTYAWNRLNIYRQRVYGVTTAVVKVGYQYTDCT-DIVWDIQTTKLSGHDMS 1674
            .|.::.|.|.|.:.:||.|::.:.|||||:|:|.|:|.|||:|..|. .::|:.:|..|.|::::
Zfish  1042 HLLQKWFHASPNLAYTYIWDKTDAYRQRVHGLTEALVSVGYEYETCPGQLLWEKRTAVLQGYELN 1106

  Fly  1675 ISEVGGWNLDIHHRYNFHEGILQKGDGSNIYL-RNKPRIILTTMGDGHQRPLECPDCDGQATKQR 1738
            .|.:|.|:||.||..|...|||.||.|.||:| :.:|.||.:.||:|.:|.:.||.|.|.|...:
Zfish  1107 PSNLGSWSLDKHHMLNVRSGILHKGSGENIFLSQQQPPIINSIMGNGRRRSISCPSCSGMAEGNK 1171

  Fly  1739 LLAPVALAAAPDGSLFVGDFNYIRRIMTDGSIRTVVKL------NATRVSYRYHMALSPLDGTLY 1797
            ||||:|:|...||:|:|||.|::||:....:...|::|      ::...|::|::|:.|:.|:|:
Zfish  1172 LLAPMAVACDGDGNLYVGDLNFVRRVYPSLNTTAVLELRNKDLRHSNSPSHKYYLAVDPMSGSLF 1236

  Fly  1798 VSDPESHQIIRVRDTNDYSQPEL-NWEAVVGSGERCLPGDEAHCGDGALAKDAKLAYPKGIAISS 1861
            :||..|.||.|||..|. ::|.| |.:.|.|:||:|:|.|||.||||..|.:|.|..|:|:|:..
Zfish  1237 LSDTNSRQIYRVRSLNG-ARPLLDNAQVVAGTGEQCVPFDEARCGDGGKALEATLMSPRGVALDK 1300

  Fly  1862 DNILYFADGTNIRMVDRDGIVSTLIGNHMHKSHWKPIPCEGTLKLEEMHLRWPTELAVSPMDNTL 1926
            :.::||.|.|.||.||::||:||||..: ..:..:|:.|:.::.:.::.|.|||:||::||||:|
Zfish  1301 NGLMYFVDATMIRKVDQNGIISTLIKTN-DLTAVRPLSCDSSMDVSQVRLEWPTDLAINPMDNSL 1364

  Fly  1927 HIIDDHMILRMTPDGRVRVISGRPLHCATASTAYD-TDLATHATLVMPQSIAFGPLGELYVAESD 1990
            :::::::|||::.:.:|.:|:|||:||......|. :.||.|:.|....:||....|.||:||:|
Zfish  1365 YVLENNVILRISENHQVSIIAGRPMHCQVPGIDYSLSKLAIHSALESATAIAISHTGVLYIAETD 1429

  Fly  1991 SQRINRVRVIGTDGRIAPFAGAESKCNCL-ERGCDCFEAEHYLATSAKFNTIAALAVTPDSHVHI 2054
            .:||||:|.:.|.|.|:..|||.|:|:|. :..|:||..:...|..|..|...:|||:||..::|
Zfish  1430 EKRINRIRQVSTSGEISLVAGATSECDCKNDVNCNCFSGDEGYAADAFLNCPTSLAVSPDGTLYI 1494

  Fly  2055 ADQANYRIRSVMSSIPEASPSREYEIYAPDMQEIYIFNRFGQHVSTRNILTGETTYVFTYNVNTS 2119
            ||..|.|:|||..:.|.|:.|.:||:.:...||:|:|:..|.|..|.:::||...|.|||.:
Zfish  1495 ADLNNIRVRSVRGNRPNATASGQYEVGSSLEQELYVFSADGLHRQTISLITGLPLYNFTYGL--- 1556

  Fly  2120 NGKLSTVTDAAGNKVFLLRDYTSQVNSIENTKGQKCRLRMTRMKMLHELSTPDNYNVTYEYHGPT 2184
            :|:|:.||||:.|.:.:.|:.:..:..:...:.|...|.|.....|..:|..........|...|
Zfish  1557 DGELAAVTDASNNTLRVRREASGSIRLVLLPENQVVTLGMDPAGNLRSVSALSQEVAQLSYDANT 1621

  Fly  2185 GLLRTKLDSTGRSYVYNYDEFGRLTSAVTPTGRVIELSFDLSVKGAQVKVSENAQKEMSLLIQGA 2249
            .||.:|.|.||.:..||||..||||:...|||.|..|.       .:::.|.|...|.|......
Zfish  1622 ELLASKSDETGWTNFYNYDNEGRLTNVTYPTGVVTSLR-------REMEESINIDMESSNRDDDV 1679

  Fly  2250 TVIVRNGAAESRTTVDMDGSTTSITPWGHNLQMEVA------------PYTILAEQSPLLGE--- 2299
            ||:....:.||..||..|....|...: ||..:.|:            |:.|....||.:|.
Zfish  1680 TVVTNLSSVESSYTVVQDQVRNSYQLY-HNGTLRVSYANGMGISFHTEPHIIAGSVSPTIGRRNI 1743

  Fly  2300 SYPVPAKQRTEIAGDLANRFEWRYFVRRQQPLQAGKQSKGPPRPVTEVGRKLRVNGDNVLTLEYD 2364
            |.|..:.         .|..|||  :|::  |..||        ||..||||||:..|:|:::||
Zfish  1744 SLPTDSG---------LNSIEWR--MRKE--LTKGK--------VTVFGRKLRVHSRNLLSIDYD 1787

  Fly  2365 RETQSVVVMVDDKQELLNVTYDRTSRPISFRPQSGDYADVDLEYDRFGRLVSWKWGVLQEAYSFD 2429
            |.|::..:..|.::..|.:.||...||.::.| |...|.|::.|...||||..:.|.:.|...||
Zfish  1788 RNTRTEKIYDDHRKFTLRIIYDAQGRPATWLP-SSSLALVNVSYSPTGRLVGLQRGSMSEKSEFD 1851

  Fly  2430 RNGRLNEIKYGDGSTMVYAFKDMFGSLPLKVTTPRRSDYLLQYDDAGALQSLTTPRGHIHAFSLQ 2494
            ..||:....:.||....:::.|....|.|:.:   :..|:..:|.||.|.::|.|....|..:..
Zfish  1852 TFGRILSRTFVDGKIWSFSYVDKSMVLLLQQS---QKQYVFDFDTAGRLTAVTMPSMARHTMATH 1913

  Fly  2495 TSLGFFKYQYYSPINR----HPFEILYNDEGQILAKIHPHQSGKVAFVHDTAGRLETILAGLSST 2555
            .|:|:.:..|..|.:.    |.|.:    :|:..|..:.....:|.:.:...|:|..:|...::.
Zfish  1914 VSVGYIRNTYNPPESNATVIHDFSV----DGRPCAMFYLGTGRRVLYKYGKLGKLSEVLYDATAV 1974

  Fly  2556 HYTYQDTTSLVKSVEVQEPGFELRREFKYHAGILKDEKLRFGSKNSLASARYKYAY-DGNARLSG 2619
            .:.|.:||.::|.|.:|..||.....:: ..|.|.|:::...|:..:.:||:.|.| |.:.|::.
Zfish  1975 TFGYDETTGVLKMVNLQSGGFSCTIRYR-KLGPLVDKQMYRFSEEGMVNARFDYTYHDNSFRVAS 2038

  Fly  2620 IEMAIDDKELPTTRYKYSQNLGQLE-------VVQDLKITRNAFNRTVIQDSAKQFFAIVDYDQH 2677
            |:..|.:..||...|:|.:..|::|       :..|:    |....|.:...:|.|      |.|
Zfish  2039 IKPVIGETPLPVDLYRYDEISGKVEHFGKFGIIYYDI----NQIITTAVMTLSKHF------DAH 2093

  Fly  2678 GRVKSVLMNVKNIDVFRLELDYDLRNRIKSQKTTFG--RSTAFDKINYNADGHV--VEVLGTNNW 2738
            ||:|.|...:....::.:.:.||...|:..::...|  .:|...:..|:.||.:  |:|...:.|
Zfish  2094 GRIKEVQYEIFRSLMYWMTVQYDSMGRVIKRELKIGPYANTTQYRYEYDGDGQLVGVKVDDWSTW 2158

  Fly  2739 KYLFDENGNTVGVVDQGEK---FNLGYDIGDRVIKVGDVEFNNYDARGFVVKRGEQKYRYNNRGQ 2800
            :|.:|.||| :.:::.|..   ..|.||:.||:.::||::: ..|..|.:::||...:.||::|.
Zfish  2159 RYSYDLNGN-LHLLNPGNSARLLPLRYDLRDRITRLGDMQY-QLDEDGVLMQRGSDVFEYNSKGL 2221

  Fly  2801 LIHSFERERFQSW---YYYDDRSRLVAWHDNKGNTTQYYYANPRTPHLVTHVHFPKISRTMKLFY 2862
            |..::.|.. ..|   |.||...|.|:...::|...||:||:...|..||||:....:.....:|
Zfish  2222 LERAYSRTA-GGWSVRYRYDGLGRRVSRRTSEGEHQQYFYADLNYPTRVTHVYNHTRAEITSFYY 2285

  Fly  2863 DDRDMLIALE-HEDQRYYVATDQNGSPLAFFDQNGSIVKEMKRTPFGRIIKDTKPEFFVPIDFHG 2926
            |.:..|.|:| ...:.||:|:|..|:|||.|..||.:||:|:.|.:|.|..|:.|:|.:.:.|||
Zfish  2286 DLQGHLFAMEVSGGEEYYIASDNVGTPLAIFSSNGQMVKQMQYTAYGEIYHDSNPDFQLILGFHG 2350

  Fly  2927 GLIDPHTKLVYTEQRQYDPHVGQWMTP---LWETLATEMSHPTDVFIYRYHNNDPINPN-KPQNY 2987
            ||.|..||||:..||.||...|:|:.|   ||..:..|   |....:|.:.||:|::.. ..:||
Zfish  2351 GLYDSLTKLVHFAQRDYDVLAGRWIAPDHTLWSKIGKE---PAPFNLYMFKNNNPLSDMIDVKNY 2412

  Fly  2988 MIDLDSWLQLFGYDLNNM-----QSSRYTKLAQYTPQASIKSNTLAPDFGVISGLECIVEKTSEK 3047
            :.|:.|||.:||:.|:|:     :.|.|.....|...||..|:...    :.:|::..|::.::.
Zfish  2413 VTDVKSWLVMFGFQLSNIIPGFPRHSLYFVNPPYEIFASQDSDNAQ----LFTGVQHSVDRHNQA 2473

  Fly  3048 FSDFDFVPKPLLKMEPKMRNLLPRVSYRR---------GVFGEGVLLSRIGGRALVSVVDGSNSV 3103
            |          :.:|.:..|...|..:.:         .:.|:|::|:...|..|   .|.|:|.
Zfish  2474 F----------MVLEGRRLNKQRRTKHDKPGYWFGTSTPIVGKGMMLAIKEGHVL---TDLSSSA 2525

  Fly  3104 VQD--VVSSVFNNSYFLD-LHFSIHDQDVFYFVKDNVLKLRDDNEELRRLG---------GMFNI 3156
            .:|  .:|.:.:|:.:|: .|::|..:|..:|||   |.|.|  .:|..||         ...||
Zfish  2526 SEDSRKISQILSNAIYLEGTHYTIEGRDCHFFVK---LGLAD--SDLLALGLSGGHKSLESGINI 2585

  Fly  3157 STHEISDHGGSAAKELRLHGPDAVVIIKYGVDP---EQERHRILKHAHKRAVERAWELEKQLVAA 3218
            :....|..|.:    |.:|.......|:||:..   |:||.|:|:.||:||:..||..|:|.|..
Zfish  2586 TISGRSRRGVT----LEIHSSKLTYSIRYGLSAEALEKERSRVLEQAHQRALSGAWAWEQQQVRE 2646

  Fly  3219 GFQGRGDWTEEEKEELVQHGDVDGWNGIDIHSIHKYPQLADDPGNVAFQRDAKRKRR 3275
            |.:|...|.|.|:.:|:..|.|.|:.|..:..:.:||:|||...|:.|.:..:..||
Zfish  2647 GREGGRVWAETERGQLLAMGKVAGYEGYYVLPVEQYPELADSSANIQFLKQNEMGRR 2703

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ten-m	NP_001262211.1	TNFRSF	1069..1198	CDD:304602	67/128 (52%)
		CRD2	1106..1151	CDD:276900	20/44 (45%)
		EGF_2	1139..1162	CDD:285248	11/22 (50%)
		Keratin_B2	1162..1330	CDD:279797	86/167 (51%)
		EGF_2	1167..1194	CDD:285248	16/26 (62%)
		DUF3844	1171..>1235	CDD:289707	31/63 (49%)
		EGF_2	<1272..1294	CDD:285248	11/21 (52%)
		NHL	1750..2065	CDD:302697	129/323 (40%)
		NHL repeat	1784..1830	CDD:271320	19/46 (41%)
		NHL repeat	1854..1888	CDD:271320	17/33 (52%)
		NHL repeat	1911..1950	CDD:271320	17/38 (45%)
		NHL repeat	1972..2005	CDD:271320	14/32 (44%)
		NHL repeat	2039..2065	CDD:271320	12/25 (48%)
		RHS_repeat	2183..2218	CDD:283287	18/34 (53%)
		RhsA	2347..3020	CDD:225750	207/704 (29%)
		YD_repeat_2x	2795..2836	CDD:273728	13/43 (30%)
		Rhs_assc_core	2905..2980	CDD:274730	31/77 (40%)
		Tox-GHH	3193..3268	CDD:292269	29/74 (39%)
tenm2b	XP_021324871.1	Ten_N	9..317	CDD:310827	73/409 (18%)
		Metallothi_Euk2	523..602	CDD:315478	40/78 (51%)
		Keratin_B2	610..>728	CDD:330888	60/120 (50%)
		EGF_CA	741..774	CDD:238011	17/33 (52%)
		CarboxypepD_reg	866..>927	CDD:316170	33/63 (52%)
		NHL	1175..1505	CDD:302697	132/331 (40%)
		NHL repeat	1175..1214	CDD:271320	14/38 (37%)
		NHL repeat	1226..1269	CDD:271320	18/43 (42%)
		NHL repeat	1293..1327	CDD:271320	17/33 (52%)
		NHL repeat	1349..1388	CDD:271320	17/38 (45%)
		NHL repeat	1411..1444	CDD:271320	14/32 (44%)
		NHL	1474..>1575	CDD:302697	40/103 (39%)
		NHL repeat	1479..1505	CDD:271320	12/25 (48%)
		NHL repeat	1481..1522	CDD:271320	18/40 (45%)
		RhsA	1624..2419	CDD:225750	247/848 (29%)
		Tox-GHH	2621..2696	CDD:317945	29/74 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170581619
Domainoid	1	1.000	1065	1.000	Domainoid score	I23
eggNOG	1	0.900	-	-		E1_KOG1225
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1467	1.000	Inparanoid score	I109
OMA	1	1.010	-	-		QHG52630
OrthoDB	1	1.010	-	-		D5817at33208
OrthoFinder	1	1.000	-	-		FOG0000741
OrthoInspector	1	1.000	-	-		otm24228
orthoMCL	1	0.900	-	-		OOG6_100953
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X442
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.670