DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ten-m and si:dkey-237h12.3

DIOPT Version :9

Sequence 1:NP_001262211.1 Gene:Ten-m / 40464 FlyBaseID:FBgn0004449 Length:3349 Species:Drosophila melanogaster
Sequence 2:XP_021336914.1 Gene:si:dkey-237h12.3 / 567508 ZFINID:ZDB-GENE-081027-3 Length:2711 Species:Danio rerio


Alignment Length:2972 Identity:901/2972 - (30%)
Similarity:1405/2972 - (47%) Gaps:472/2972 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly   513 VNKRRKY---DHGTVEAEHIKHEEEEEEDEQKLER-----HEAIGMATELTTESETSTLPAVIDD 569
            |.:||.|   ..|..|... ..|.|.:.||.:..|     ....|.::.||.:|.:|:......|
Zfish     3 VKERRPYCSLSRGRRERGR-DWEREGDRDEGEGFREGPGSRRQTGSSSVLTQKSYSSSETLKAFD 66

  Fly   570 DNQSDNSSSGPTPETTVRSDTDDIVEINTPPSQTAQRTFAAVSHQP----------AIEHDFQIK 624
            .:.|.....|......|..|.:   |...|....:.|........|          .:.|..|:.
Zfish    67 QHPSTQGLYGHRMPDMVPRDAE---EYRAPGQSLSLRQLGICGPAPRRGLSFCAETGLGHHTQLS 128

  Fly   625 GTD----AGGLQ------------TEKPATDDINNERDLADNYEVDSKE-------PTSPGTPPQ 666
            |.|    .||:.            .:...:...|:...|.|. |.|:|.       |:..|.|| 
Zfish   129 GADHIQNVGGISPDCAMLWVKSHGRDSRLSSRSNSALTLTDT-EQDNKSDQENDQLPSQAGPPP- 191

  Fly   667 GKVSQQTGKASLQSLQSESDLMMNDASHYEDIDIVKLDGLTISHEEEIYKTADKENMAPKNQP-- 729
                                                |....|.|::....|:..:::|  |||  
Zfish   192 ------------------------------------LPPAPIQHKQHPSVTSLNQSLA--NQPAE 218

  Fly   730 ----SQHIDRSQNEVLKGHQQGDEKQPQLEPLKPYVSERVDLPGKRIFLNLTIATDEGSDSVYTL 790
                |:.:...:|.||.|:                    |.|..:...|.    |..|:.|::| 
Zfish   219 LQSASECVQLQENWVLGGN--------------------VGLENRHFLLK----TGTGTTSLFT- 258

  Fly   791 HVEVPTGGGPHFIKEVLTHEKPTAQADSCVPEPPPRMPDCPCSCLPPPAPIYLDDTVDIDSAPPA 855
                                                          .|.|.|...|..:.| |||
Zfish   259 ----------------------------------------------TPNPGYTMATGTVYS-PPA 276

  Fly   856 KTVTTSTISAPINPFHSEEEDDEDGVRDEEQTPSSSTAT-------------------NLPSTEI 901
            :.:|.:|:|.....|:...:.     ...:.|..|:.|.                   |....::
Zfish   277 RPLTRNTLSRGAFKFNKSPKR-----CSWKCTALSAVAVATLLTVLLCYCIAMHVLGLNWKLKDV 336

  Fly   902 DNHIAAFTEPAVGAGGVPFACPDVMPVLILEGARTFPARSFPPDGTT------------------ 948
            |||  ||                       |..|..|. :||.:..|                  
Zfish   337 DNH--AF-----------------------ENGRAKPV-TFPTNTVTAVSADGRVGVMLQYNSTL 375

  Fly   949 -FGQITLGQKLTKEIQPYSYWNMQFYQSEPAYVKFDYTIPRGASIGVYGRRNALPTHTQYHFKEV 1012
             .||:.:||::...|.|..:|..:....:|.::||:.:|.:.|.|||||||...|:||||.|.|:
Zfish   376 DTGQVEMGQQVAHAIPPGVFWRSRLIIEQPHFLKFNISIQKNALIGVYGRRGLPPSHTQYDFVEL 440

  Fly  1013 LSGFSASTRTARAAHLSITREV---------------TRYMEPGHWFVSLYNDDGDVQELTFYAA 1062
            |.|    :|......:.:..|:               .:|:..|.|.::.|||...|:.:::...
Zfish   441 LDG----SRLISRERVQLDPELRDRLEIPVSVQQAGFIQYLHTGVWHLAFYNDGRTVEPVSYNTI 501

  Fly  1063 VAEDMTQNCPNGCSGNGQCLLGHCQCNPGFGGDDCSESVCPVLCSQHGEYTNGECICNPGWKGKE 1127
            |.|.:.: ||:.|.|||:|:.|.|.|.|||.|..||.:.||||||.:|:|..|.|.|..||||.|
Zfish   502 VLESVME-CPHNCYGNGECVSGTCNCFPGFLGPYCSRAACPVLCSGNGQYNGGRCQCYSGWKGIE 565

  Fly  1128 CSLRHDECEVADCSGHGHCVSGKCQCMRGYKGKFCEEVDCPHPNCSGHGFCADGTCICKKGWKGP 1192
            |.:...:|..|.|.|||.||||.|.|..|::|..|::|||..|:|||||.|..|.|.|..||.|.
Zfish   566 CDVPSGQCMDAQCGGHGLCVSGSCICNPGFRGDNCDQVDCVDPSCSGHGSCLHGQCHCTSGWTGS 630

  Fly  1193 DCATMDQDALQCLPDCSGHGTFDLDTQTCTCEAKWSGDDCSKELCDLDCGQHGRCEGDACACDPE 1257
            :|.|  |.:| |...|||||||..:|.:|.|||.|:|.|||.|:|..||..||.|.|..|.|...
Zfish   631 NCET--QLSL-CPEHCSGHGTFQTETSSCVCEANWTGPDCSSEVCAADCSPHGVCVGGVCRCADG 692

  Fly  1258 WGGEYCNTRLCDVRCNEHGQCKNGTCLCVTGWNGKHCTI----------------EGCPNSCAGH 1306
            |.|..|....|...|.|||.|:.|.|.|..||.|::|.|                :.||..|..:
Zfish   693 WSGAGCEQEDCQAHCGEHGVCRKGKCECHQGWTGENCNIAHFLDSKIKADWIGYRDSCPGLCNNN 757

  Fly  1307 GQCRVSGEGQWECRCYEGWDGPDCGIALELNCGDSKDNDKDGLVDCEDPECCASHVCKTSQLCVS 1371
            |:|.:...| |.|.|..||.|..|.:|:|..|.|.|||:.||||||.||:||....|:....|..
Zfish   758 GRCILDQNG-WHCLCQSGWRGVGCDVAMETICSDGKDNEGDGLVDCMDPDCCIHSACQGQTYCRG 821

  Fly  1372 APKPIDVLLRKQPPAITASFFERMKFLIDESSLQNYAKLETFNESIFWNYFNASRSAVIRGRVVT 1436
            ||.|..:.....|.:....|::|:.||:............|||.|:.         :|:||:|||
Zfish   822 APDPSTIQQPSSPTSDAQGFYQRVGFLVAPGGTHTLPGENTFNSSLV---------SVVRGQVVT 877

  Fly  1437 SLGMGLVGVRVSTTTLL----EGFTLTRDDGWFDLMVNGGGAVTLQFGRAPFRPQSRIVQVPWNE 1497
            ..|..|:||.||   ||    :|:|:||.||.|||:||||.|:|::|.|||:....|.|.:.|..
Zfish   878 GDGTPLIGVNVS---LLHYPQQGYTITRQDGMFDLLVNGGKALTMRFERAPYSAVHRTVWLSWRV 939

  Fly  1498 VVIIDLVVMSMSEEKGLAVTTTHTCFAHDYDLMKPVVLASWKHGFQGACPDRSAILAESQVIQES 1562
            ..::|.:|| ..||:.:.     ||.....|...|.:.||....|..:.|:.|.|:.|:||:.|.
Zfish   940 FHVMDTLVM-RKEERDMP-----TCEFSGLDRPSPRITASPLSTFYRSSPEASPIIPETQVLHEQ 998

  Fly  1563 LQIPGTGLNLVYHSSRAAGYLSTIKLQLTPDVIPTSLHLIHLRITIEGILFERIFEADPGIKFTY 1627
            ..|||:.|:|:|.||||:.|...:|:.||...:|..|..:||.:.:||.:|::.|.|...:.:::
Zfish   999 TAIPGSDLDLIYLSSRASAYKPVLKVILTQSSVPFGLARVHLMVAVEGRMFQKQFPASARLSYSF 1063

  Fly  1628 AWNRLNIYRQRVYGVTTAVVKVGYQYTDCTDIV-WDIQTTKLSGHDMSISEVGGWNLDIHHRYNF 1691
            .|::.:.|.|:|||:..|||.||::|..|.::: |:.:|..|.|:::..|.:|||.||.||..:.
Zfish  1064 IWDKTDAYSQKVYGLAEAVVSVGFEYESCLNVILWEKRTATLQGYELEASNMGGWTLDKHHILDV 1128

  Fly  1692 HEGILQKGDGSNIYLRNKPRIILTTMGDGHQRPLECPDCDGQATKQRLLAPVALAAAPDGSLFVG 1756
            ..|||.||:|.|::|...|.||.|.||:|.:|.:.||.|:|||...:||||||||...||||:||
Zfish  1129 PNGILYKGNGENVFLSQLPPIISTVMGNGRRRSISCPSCNGQAEGNKLLAPVALAWGIDGSLYVG 1193

  Fly  1757 DFNYIRRIMTDGSIRTVVKL------NATRVSYRYHMALSPLDGTLYVSDPESHQIIRVRDTNDY 1815
            ||||||||...|::.:|::|      ::...::||::...|:.|.|:|||..|.:|.....:...
Zfish  1194 DFNYIRRIYPSGNVTSVMELRNKDFRHSNNPAHRYYLTTDPVTGRLFVSDTNSRRIYSPLGSLTS 1258

  Fly  1816 SQPELNWEAVVGSGERCLPGDEAHCGDGALAKDAKLAYPKGIAISSDNILYFADGTNIRMVDRDG 1880
            |:.:.|.|.|.|:|:.|||.|||.||||..|.:|.|..|||||:..:.::||.|||.||.||::|
Zfish  1259 SELQQNVEVVAGTGDHCLPFDEAQCGDGGPATEALLTGPKGIAVDKNGLIYFVDGTVIRKVDQNG 1323

  Fly  1881 IVSTLIGNHMHKSHWKPIPCEGTLKLEEMHLRWPTELAVSPMDNTLHIIDDHMILRMTPDGRVRV 1945
            |:|||:|::...|. :|:.|:..:.:.::.|.|||:|:||||||:|.::|..::||:|.:|:|.|
Zfish  1324 IISTLLGSNDLASA-RPLSCDSVMDVHQVSLEWPTDLSVSPMDNSLFVLDGSVVLRITEEGQVSV 1387

  Fly  1946 ISGRPLHCATAST---AYDTDLATHATLVMPQSIAFGPLGELYVAESDSQRINRVRVIGTDGRIA 2007
            .:||||||...||   ..:|..||...|..|.:||....|.|::||:|.::::|:|.:..||:|.
Zfish  1388 AAGRPLHCPMPSTDISVTETQRATQTHLESPSAIAVSFSGVLHIAETDERKMSRIRSVAADGQIT 1452

  Fly  2008 PFAGAESKCNC-LERGCDCFEAEHYLATSAKFNTIAALAVTPDSHVHIADQANYRIRSVMSSIPE 2071
            ..|||.|.|:| .:..|||:......|..|:.|..::|...||..:::||..|.|||::..:.|.
Zfish  1453 HLAGAPSDCDCKTDVNCDCYLTGDGFAKDARLNGPSSLVAAPDGTLYVADLGNIRIRTIGRNKPA 1517

  Fly  2072 ASPSREYEIYAPDMQEIYIFNRFGQHVSTRNILTGETTYVFTYNVNTSNGKLSTVTDAAGNKVFL 2136
            .:.....|:.:...||:|:|:..|.|..|.|::||:..|.|:|   ::.|.|::|.|:.||.:.:
Zfish  1518 LNSMGLLEVASSGEQEVYMFDSNGTHQHTANLITGDFKYNFSY---SNEGDLTSVADSHGNTLRI 1579

  Fly  2137 LRDYTSQVNSIENTKGQKCRLRMTRMKMLHELSTPDNYNVTYEYHGPTGLLRTKLDSTGRSYVYN 2201
            .||.:.....|.....|...|.:.....|..|.|.....|...|||.:|||.|...::|.:..|:
Zfish  1580 RRDASRLPVRIVAPDNQVIWLTVGSSGGLKTLGTQGREQVLLTYHGNSGLLATMSTASGWTTFYD 1644

  Fly  2202 YDEFGRLTSAVTPTGRVIELSFDLSVKGAQVKVSENAQKEMSLLIQGATVIVRNGAAESRTTVDM 2266
            ||..||||:...|||.|..|::::.......|  |:.::|     :..::.....|.::..|:..
Zfish  1645 YDTEGRLTNVTFPTGVVTSLAYEMDTVSTVEK--ESFERE-----EAGSITTNQSAIQNILTLQQ 1702

  Fly  2267 DGSTTSI------TPW-----GHNLQMEVAPYTILAEQSPLLGESYPVPAKQRTEIAGDLA-NRF 2319
            |....|.      :.|     |.|...:..|: |||      |.|.|..|::...:..|.. |..
Zfish  1703 DQLKNSYVVGYDHSLWILYANGMNTHYQTEPH-ILA------GASSPTLARRNMTLPDDSGQNLV 1760

  Fly  2320 EWRYFVRRQQPLQAGKQSKGPPRPVTEVGRKLRVNGDNVLTLEYDRETQSVVVMVDDKQELLNVT 2384
            |||:  |::|     .::|     ||..||||||||.|:|:::|||..:...:..|.::.||.:.
Zfish  1761 EWRF--RKEQ-----TRTK-----VTVFGRKLRVNGRNILSVDYDRALRIEKIYDDHRKFLLKIG 1813

  Fly  2385 YDRTSRPISFRPQSGDYADVDLEYDRFGRLVSWKWGVLQEAYSFDRNGRLNEIKYGDGSTMVYAF 2449
            ||...:|..:.| |.....|:|.....|:|.:..||.:.:...:|..|||....:.||.|..|.:
Zfish  1814 YDTAGQPTLWMP-SSKLLPVNLTRSSNGQLSAIHWGSVSDRVEYDGQGRLLSRTFPDGKTWSYTY 1877

  Fly  2450 KDMFGSLPLKVTTPRRSDYLLQYDDAGALQSLTTPRGHIHAFSLQT--SLGFFKYQYYSPINRHP 2512
            .:.  |..|.:.:.|:  |:.:||..|.|.::|.|  .:..::::|  |:.:::..|:.|.:...
Zfish  1878 LEK--STVLILASQRQ--YVFEYDPQGGLSAVTMP--SVARYTMETIRSVSYYRNLYHMPESNAS 1936

  Fly  2513 FEILYNDEGQILAKIHPHQSGKVAFVHDTAGRLETILAGLSSTHYTYQDTTSLVKSVEVQEPGFE 2577
            ..:.|.::|::|.........:|.:.:....:|..:|...:...:||.:|..::|:|.:|..||.
Zfish  1937 VAVDYTEDGRLLRVAQLGTGRRVLYRYRWHNKLSEVLYDSTRVSFTYDETAGVLKTVNLQSEGFI 2001

  Fly  2578 LRREFKYHAGILKDEKLRFGSKNSLASARYKYAYDGNARLSGIEMAIDDKELPTTRYKYSQNLGQ 2642
            ....:: ..|.|.|.::...|::.:.:||:.||||.:.|::.::..|::..||...|:|....|:
Zfish  2002 CTIRYR-QLGPLVDRQIYRFSEDGMVNARFDYAYDSSLRVTSVQGVINETPLPIDLYQYDDISGK 2065

  Fly  2643 LE-------VVQDLKITRNAFNRTVIQDSAKQFFAIVDYDQHGRVKSVLMNVKNIDVFRLELDYD 2700
            :|       :..|:    |....|.:....|.|      |.|.||:.:...:....:|.:.:.||
Zfish  2066 VEQFGKFGVIYYDI----NQIISTSVMTYTKHF------DGHSRVREIQYELFRSLLFWITVQYD 2120

  Fly  2701 LRNRIKSQKT---TFGRSTAFDKINYNADGHVVEVLGTN--NWKYLFDENGN--TVGVVDQGEKF 2758
            ...|:..::.   .|..:|.: ...|:.||.:..|....  .|:|.:|.|||  .:...:.....
Zfish  2121 DMGRVTKREMKIGPFANATKY-SYEYDVDGQLQAVYLNEKMTWRYSYDLNGNIHLLSPANSARIM 2184

  Fly  2759 NLGYDIGDRVIKVGDVEFNNYDARGFVVKRGEQKYRYNNRGQLIHSFERERFQSW---YYYDDRS 2820
            .|.||:.||:.::||::: ..|..||:.:||.:.::||:.|.|...:.:.  ..|   :.||...
Zfish  2185 PLRYDLRDRITRLGDLQY-ELDEDGFLQQRGSEIFQYNSNGHLERVYSKS--SGWSVQHRYDGLG 2246

  Fly  2821 RLVAWHDNKGNTTQYYYANPRTPHLVTHVHFPKISRTMKLFYDDRDMLIALE-HEDQRYYVATDQ 2884
            |.|:.....|...|::||:...|..:|||:....|:...|:||.:..|.|:| .....:|:|.|.
Zfish  2247 RRVSTKSTVGQHLQFFYADLSYPSRITHVYNHSSSQITSLYYDLQGHLFAMEISNGAEFYIACDN 2311

  Fly  2885 NGSPLAFFDQNGSIVKEMKRTPFGRIIKDTKPEFFVPIDFHGGLIDPHTKLVYTEQRQYDPHVGQ 2949
            .|:|||.|..:|.::|::..|.:|.:..|:.|:..:.|.|||||.||.|:|::...|.||...|:
Zfish  2312 TGTPLAVFGSDGILLKQVHYTAYGEVYSDSNPDIQLVIGFHGGLYDPLTRLLHFGVRDYDIMAGR 2376

  Fly  2950 WMTP---LWETLATEMSHPTDVFIYRYHNNDPINP-NKPQNYMIDLDSWLQLFGYDLNN------ 3004
            |..|   |||.|:   .:|....:|.:.||:||:. .|..:|:.|::|||..||:.|:|      
Zfish  2377 WTAPDFMLWENLS---KNPGPFNLYMFRNNNPISKVQKVGDYLTDVNSWLVTFGFHLHNSIPGFP 2438

  Fly  3005 MQSSRYTKLAQYTPQASIKSNTLAPDFGVISGLECIVEKTSEKFSDFDFVP-----------KPL 3058
            :..|..|:::....::.:..: |.|.|.|    :..|.:.::.|..|..:|           ||.
Zfish  2439 IPVSEMTQVSYELAKSQVWDD-LTPSFAV----QQHVIRQAKAFLRFGDLPQVEFGHSHCSSKPW 2498

  Fly  3059 LKMEPKMRNLLPRVSYRRGVFGEGVLLSRIGGRALVSVVDGSNSVVQDV--VSSVFNNSYFL-DL 3120
            |..           :....:.|.|::|:...|..:...:..:|   :|.  |:::.|.:.:| ||
Zfish  2499 LWF-----------ALSDSLIGRGIMLALYKGIVITRALSLAN---EDCVKVANILNGALYLKDL 2549

  Fly  3121 HFSIHDQDVFYFVKDN-------VLKLRDDNEELRR------------LGGMFNISTHEISD--- 3163
            ||.:..:|..:|||.|       .|:|....:||..            |||    .|...:|   
Zfish  2550 HFIVDGRDTHFFVKMNSPEADLAALRLTSGRKELENAVNVTVSQSTAVLGG----RTRRFADVEF 2610

  Fly  3164 HGGSAAKELRLHGPDAVVIIKYGVDPEQERHRILKHAHKRAVERAWELEKQLVAAGFQGRGDWTE 3228
            ..||    |.||       ::||...::||.|:|:.|.:||:..:|..|:|.|..|.:|...|||
Zfish  2611 QRGS----LTLH-------VRYGASLDEERVRVLELARQRALAISWTREQQRVRNGEEGSRLWTE 2664

  Fly  3229 EEKEELVQHGDVDGWNGIDIHSIHKYPQLADDPGNVAFQRDAKRKRR 3275
            .||.:|:..|.|.|::|..:.|:.:||:|||...|:.|.|..:..:|
Zfish  2665 GEKRQLLTSGRVQGYDGYYVLSVEQYPELADSVNNMQFLRQNEIGKR 2711

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ten-mNP_001262211.1 TNFRSF 1069..1198 CDD:304602 66/128 (52%)
CRD2 1106..1151 CDD:276900 23/44 (52%)
EGF_2 1139..1162 CDD:285248 12/22 (55%)
Keratin_B2 1162..1330 CDD:279797 78/183 (43%)
EGF_2 1167..1194 CDD:285248 14/26 (54%)
DUF3844 1171..>1235 CDD:289707 34/63 (54%)
EGF_2 <1272..1294 CDD:285248 11/21 (52%)
NHL 1750..2065 CDD:302697 134/324 (41%)
NHL repeat 1784..1830 CDD:271320 15/45 (33%)
NHL repeat 1854..1888 CDD:271320 19/33 (58%)
NHL repeat 1911..1950 CDD:271320 20/38 (53%)
NHL repeat 1972..2005 CDD:271320 11/32 (34%)
NHL repeat 2039..2065 CDD:271320 10/25 (40%)
RHS_repeat 2183..2218 CDD:283287 15/34 (44%)
RhsA 2347..3020 CDD:225750 194/702 (28%)
YD_repeat_2x 2795..2836 CDD:273728 11/43 (26%)
Rhs_assc_core 2905..2980 CDD:274730 29/77 (38%)
Tox-GHH 3193..3268 CDD:292269 30/74 (41%)
si:dkey-237h12.3XP_021336914.1 Ten_N 42..301 CDD:310827 62/378 (16%)
SerH <519..>698 CDD:284327 92/181 (51%)
EGF_2 703..729 CDD:285248 12/25 (48%)
EGF 754..777 CDD:306513 9/23 (39%)
NHL 1150..1511 CDD:302697 154/361 (43%)
NHL repeat 1179..1218 CDD:271320 22/38 (58%)
NHL repeat 1230..1280 CDD:271320 17/49 (35%)
NHL repeat 1297..1331 CDD:271320 19/33 (58%)
NHL repeat 1353..1400 CDD:271320 25/46 (54%)
NHL repeat 1417..1450 CDD:271320 11/32 (34%)
NHL 1481..>1554 CDD:302697 23/72 (32%)
NHL repeat 1485..1511 CDD:271320 10/25 (40%)
NHL repeat 1487..1515 CDD:271320 9/27 (33%)
NHL repeat 1517..1554 CDD:271320 11/36 (31%)
RhsA 1559..>2208 CDD:225750 178/697 (26%)
RhsA 2331..2409 CDD:332076 30/80 (38%)
Tox-GHH 2629..2704 CDD:317945 30/74 (41%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C170581617
Domainoid 1 1.000 1065 1.000 Domainoid score I23
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 1467 1.000 Inparanoid score I109
OMA 1 1.010 - - QHG52630
OrthoDB 1 1.010 - - D5817at33208
OrthoFinder 1 1.000 - - FOG0000741
OrthoInspector 1 1.000 - - otm24228
orthoMCL 1 0.900 - - OOG6_100953
Panther 1 1.100 - - O PTHR11219
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X442
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
1312.910

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