DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ten-m and tnr

DIOPT Version :9

Sequence 1:	NP_001262211.1	Gene:	Ten-m / 40464	FlyBaseID:	FBgn0004449	Length:	3349	Species:	Drosophila melanogaster
Sequence 2:	NP_919364.1	Gene:	tnr / 369191	ZFINID:	ZDB-GENE-030804-1	Length:	1350	Species:	Danio rerio

Alignment Length:	1589	Identity:	300/1589 - (18%)
Similarity:	485/1589 - (30%)	Gaps:	592/1589 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly  1071 CPNGCSGNGQCLLGHCQCNPGFGGDDCSESVCPVLCSQHGEYTNGECICNPGWKGKECSLRHDEC 1135
            |.:.|.|... ::|.....|..|....|..||             .|:|..||.||.|:  ...|
Zfish   151 CSSSCCGESS-VMGRLDFVPQCGHGTFSMEVC-------------GCVCEEGWIGKNCT--EPRC 199

  Fly  1136 EVADCSGHGHCVSGKCQCMRGYKGKFCEEVDCPHPNCSGHGFCADGTCICKKGWKGPDCATMDQD 1200
            . .||||.|.|:.|.|.|.|.:.|:.|.|..|| .:||..|.|.||.|:|::.:.|.||:.
Zfish   200 P-DDCSGQGICIEGDCVCDRNFGGENCSEPRCP-SDCSDRGLCIDGECVCEEAFAGEDCSL---- 258

  Fly  1201 ALQCLPDCSGHGTFDLDTQTCTCEAKWSGDDCSKELCDLDCGQHGRCEGDACACDPEWGGEYCNT 1265
                                                        |||..|
Zfish   259 --------------------------------------------GRCLND--------------- 264

  Fly  1266 RLCDVRCNEHGQCKNGTCLCVTGWNGKHCTIEGCPNSCAGHGQCRVSGEGQWECRCYEGWDGPDC 1330
                  |::.|.|.||:|.|.:|:.|:.|::..|.|:|:..|.|:   ||  .|.|.||:.|.||
Zfish   265 ------CSDQGACVNGSCQCRSGFLGEDCSLIFCANNCSQRGVCK---EG--FCVCQEGYTGDDC 318

  Fly  1331 GIAL---ELNCGDSKDNDKDGLVDCEDPECCASHVCKTS-------QLCVSAPKPI-DVLLRKQP 1384
            ...|   .|......:|..|  :..|.|.....::....       ||.:..|..: ::.::...
Zfish   319 TSVLPPMNLRVRGVSENTID--LQWEGPAILTDYLITYEPTTPGGVQLEMRVPGNVTNITIKGLN 381

  Fly  1385 PAITASFFERMKFLIDESSLQNYAKLETFNES----IFWNYFNASRSAVIRGRVVTSLGMGLVGV 1445
            |.:             |.::..||.::....|    :...|.:.....:.:..:.||       |
Zfish   382 PGL-------------EYNVNVYAVIDNIISSPMNTLVSTYLSNPDGLLFKSIMETS-------V 426

  Fly  1446 RVSTTTLLEGFTLTRDDGW---FDLMVNGGGAVTLQ-------FGRAPFRPQSRIVQVPWNEVVI 1500
            .|....|...|     |||   |....|.|| :|.|       |.:...:|         .|...
Zfish   427 EVQWQPLDYLF-----DGWEISFIPKDNDGG-MTAQLPSTITSFHQTGLKP---------GEEYT 476

  Fly  1501 IDLVVMSMSEEKGLAVTTTHTCFAHD------YDLMKPVVLASW------------KHGFQGACP 1547
            ::||.:. .:.:.|.||.|.|.....      .|:...|....|            ::|..|...
Zfish   477 VNLVALK-DQGRSLPVTATVTTLIDGPIQLIVRDISDTVAFVEWSPPKAKVDQIILRYGLVGVEG 540

  Fly  1548 DRSAILAESQVIQESLQI--PGTGLNLVYHSSRAAGYLSTIKLQLTPDV-IPTSLHL-----IHL 1604
            .::....:..:.|.|||:  ||:...:.....|.......|..:.|.:: .|.:|.:     |.|
Zfish   541 PKTTFRLQPTLSQYSLQVLRPGSTYEVSVSGVRNGTESGVISTEFTTEIDAPKNLRVLSKTSISL 605

  Fly  1605 RI-----------------TIEGILFERIF---EADPGIKFTYAWNRLN-IYRQRVYGVTTAVVK 1648
            .:                 |:.|..::::.   ...|..|.|     || :.....||:..:.|.
Zfish   606 ELEWDNSEADVEGYSVVYSTLAGDQYDKVIVPRNDGPSTKTT-----LNELMPGTEYGIGISAVL 665

  Fly  1649 VGYQYTDCT-------DIVWDIQTTKLSGHDMSISEVGGWN-----LDIHHR--YNFHEGILQKG 1699
            ...|.|..|       |:..|:..|..:.:.:::.    |.     :| |:|  |....|:..:
Zfish   666 GANQSTPATMNARTGLDVPLDLTVTASTDNTITLL----WGTVQGPID-HYRVTYTSSSGVTTE- 724

  Fly  1700 DGSNIYLRNKPRII----LTTMGDGHQRPLECPDCDG--QATKQRLLA-----PVA--------- 1744
                   ...|:.:    ||::..|.:..:......|  |:|...:.|     |:.
Zfish   725 -------LTVPKDVTTTTLTSLQPGTEYTITVAAQRGRQQSTAATIDAFTGFRPITQLFFSEVSS 782

  Fly  1745 -------LAAAPDGSLFVGDFNYIRR-------IMTDGSIRTVVKLNATRVSYRYHMALSPLDGT 1795
                   .:.||....|:  .||..:       |..||| :|.:.|.....|.||...|..:.|
Zfish   783 DSLTVAWSSPAPPADAFI--LNYSAQDSSEDSEIALDGS-KTRITLTGLMPSRRYTATLVTMHG- 843

  Fly  1796 LYVSDPESHQIIRVRDTNDYSQPELNWEAVVGSGERCLPGDEAHCGDGALAKDAKLAYPKGIAIS 1860
                             |..|:|      ||||                  .:..:..|:.|
Zfish   844 -----------------NVTSKP------VVGS------------------VNTGMDPPRDI--- 864

  Fly  1861 SDNILYFADGTNIRMVDRDGIVSTLIGNHMHKSHWKPIPCEGTLKLEEMHLRWPTELAVSPMDNT 1925
              .:||..:                                     |.:.:.|...||
Zfish   865 --TVLYVTE-------------------------------------ESVTITWIQPLA------- 883

  Fly  1926 LHIIDDHMILRMTPDGRVRVISGRPLHCATASTAYDTDLATHATLVMPQSIAFGPLGELYVAESD 1990
              ::|.:.:...:..||:            .|...|:|:..:.            |..|:.|...
Zfish   884 --LLDYYRMSYQSSKGRM------------DSVVIDSDINNYT------------LTSLHPATEY 922

  Fly  1991 SQRINRVRVIGTDGRIAPFAGAESKCNCLERGCDCFEAEHYLATSAKFNTI------AALAVTPD 2049
            ..::|.||           ...|||                :.|:..|..|      .||.|||.
Zfish   923 EIKLNAVR-----------GSQESK----------------VITTTVFTAIDMPAELTALNVTPQ 960

  Fly  2050 SHVHIADQANYRIRSVMSSIPEASPSREYEIYAPDMQEIYIFNRFGQHVSTRNILTGETTYV--- 2111
            .             :::...|.||....|.:                 ..|||.:|.:|..|
Zfish   961 G-------------ALLRWNPPASSVDNYVL-----------------TVTRNQVTADTFLVEGN 995

  Fly  2112 ------------FTYNV--NTSNGKLSTVTDAAGNKVFLLRDYTSQVNSIENTKGQKCRLRMTRM 2162
                        .||:|  ..:.|.|::.|        ::.::.:.:::.:|....:...|...:
Zfish   996 KQEYQLSQLIPSTTYSVALYATKGPLTSGT--------VISNFVTPMDAPQNLTASEINHRSALI 1052

  Fly  2163 KMLHELSTPDNYNVTYEYHGPTGLLRTKLDSTGRSYVYN-YDEFGRLTSAVTPTGRVIELSFDLS 2226
            .....::..|||.:||:          ..|.:.:..:.: .|.:.||......|...:.|..
Zfish  1053 SWQPPIADIDNYMLTYK----------AADGSRKELILDAEDTWIRLEGLAETTEYTVRLQV--- 1104

  Fly  2227 VKGAQVKVSENAQKEMSLLIQGATVIVRNGAAESRTTVDMDGSTTSITPWG---HNLQMEV--AP 2286
            .:|.:                 .:|||    :.|.||    |:....||..   |.|..|.  ..
Zfish  1105 ARGLE-----------------TSVIV----STSFTT----GNRLFPTPQNCAQHLLNGETLGGI 1144

  Fly  2287 YTILAEQSPLLGESYPVPAKQRTEIAGDLANRFEWRYFVRRQQPLQAGKQSKGPPRPVTEVGRK- 2350
            |||...:.  |.:...|.....|:..|       |..|.|||..|             |:..||
Zfish  1145 YTIYVNRD--LSQGVQVYCDMTTDGGG-------WIVFQRRQNGL-------------TDFSRKW 1187

  Fly  2351 -------------LRVNGDNVLTLEYDRETQSVVVMVDDKQELLNVTYDR--------------- 2387
                         ..:..||:..:......:..:.| .|.||.:...|||
Zfish  1188 TDYKIGFGSLEDEFWLGLDNIHKIAAQGRYELRIDM-KDGQESVYANYDRFSIGDSKSLYKLRIG 1251

  Fly  2388 -------------TSRPISFRPQSGDYADVDLEYDRFGRLVSWKWGVLQEAYSFDRNGRLNEIKY 2439
                         .|||.|.:.:..|.|..:......|   :| |  .:..:..:.||:..|.::
Zfish  1252 EYSGTAGDSLSYHQSRPFSTKDKDNDIAVTNCALSYKG---AW-W--YKNCHRANLNGKYGESRH 1310

  Fly  2440 GDGSTMVYAFKDMFGSLPLKVTTPRRSDY 2468
            ..|... |.:|....|:|......|..:|
Zfish  1311 SQGINW-YHWKGHEFSIPFVEMKMRPFNY 1338

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ten-m	NP_001262211.1	TNFRSF	1069..1198	CDD:304602	43/126 (34%)
		CRD2	1106..1151	CDD:276900	15/44 (34%)
		EGF_2	1139..1162	CDD:285248	11/22 (50%)
		Keratin_B2	1162..1330	CDD:279797	41/167 (25%)
		EGF_2	1167..1194	CDD:285248	11/26 (42%)
		DUF3844	1171..>1235	CDD:289707	11/63 (17%)
		EGF_2	<1272..1294	CDD:285248	9/21 (43%)
		NHL	1750..2065	CDD:302697	52/327 (16%)
		NHL repeat	1784..1830	CDD:271320	11/45 (24%)
		NHL repeat	1854..1888	CDD:271320	4/33 (12%)
		NHL repeat	1911..1950	CDD:271320	6/38 (16%)
		NHL repeat	1972..2005	CDD:271320	6/32 (19%)
		NHL repeat	2039..2065	CDD:271320	6/31 (19%)
		RHS_repeat	2183..2218	CDD:283287	5/35 (14%)
		RhsA	2347..3020	CDD:225750	30/164 (18%)
		YD_repeat_2x	2795..2836	CDD:273728
		Rhs_assc_core	2905..2980	CDD:274730
		Tox-GHH	3193..3268	CDD:292269
tnr	NP_919364.1	EGF_2	199..225	CDD:285248	12/26 (46%)
		EB	234..283	CDD:279949	23/117 (20%)
		EGF_2	294..318	CDD:285248	11/28 (39%)
		fn3	323..401	CDD:278470	12/92 (13%)
		fn3	411..490	CDD:278470	20/101 (20%)
		fn3	500..579	CDD:278470	12/78 (15%)
		FN3	590..674	CDD:238020	16/88 (18%)
		fn3	682..754	CDD:278470	13/84 (15%)
		fn3	771..849	CDD:278470	19/98 (19%)
		FN3	859..935	CDD:214495	20/161 (12%)
		fn3	949..1019	CDD:278470	18/99 (18%)
		fn3	1035..1103	CDD:278470	12/77 (16%)
		FReD	1126..1336	CDD:238040	48/239 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1225
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810