DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ten-m and fn1b

DIOPT Version :9

Sequence 1:NP_001262211.1 Gene:Ten-m / 40464 FlyBaseID:FBgn0004449 Length:3349 Species:Drosophila melanogaster
Sequence 2:XP_009303829.1 Gene:fn1b / 334613 ZFINID:ZDB-GENE-030131-6545 Length:2500 Species:Danio rerio


Alignment Length:2278 Identity:407/2278 - (17%)
Similarity:681/2278 - (29%) Gaps:838/2278 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly  1060 YAAVAEDMTQNCPNGCSGNGQ----CLLGHCQCNPGFG----GDDCSESVCPVLCSQHGEYTNGE 1116
            |....::|..:|.  |.|:|:    |.:.: :|:.|..    ||..:..      ...|:|.. |
Zfish   116 YERPKDNMIWDCT--CIGSGKGKISCTIAN-RCHEGGNSYRIGDTWTRP------HDTGDYML-E 170

  Fly  1117 CICNPGWKGK-ECSLRHDECEVADCSGHGHCVSGKCQCMRGYKGKFCEEVDCPHPNCSGHGFCAD 1180
            |:|....||: .|....:.| ..|..|..:.|....|  :.|:|...  |||   .|.|.|   :
Zfish   171 CVCLGNGKGEWTCKPVAERC-YDDSLGSSYVVGQTWQ--KPYQGWMI--VDC---TCLGEG---N 224

  Fly  1181 G--TCICKKGWKGPDCAT----------MDQD--ALQCLPDCSGHGTFDLDTQTCTCEAKWSGDD 1231
            |  ||..:......|..|          :|..  .||||  |:|:|           ..:|.   
Zfish   225 GRITCTSRNRCNDQDTRTSYRIGETWSKIDSSGHTLQCL--CTGNG-----------RGEWK--- 273

  Fly  1232 CSKELCDLDCGQHGRCEGDACACDPEWG-GEYCNTRLCDV--RCN------EHGQCKNGTCLCVT 1287
                 ||.....|         ..|..| |.....|:..|  :.|      |.|.||  |...|:
Zfish   274 -----CDRHAASH---------VIPAIGTGSAVTHRVTPVMNQVNVLNELIEEGNCK--TDSGVS 322

  Fly  1288 GWNGKH-----------CTIEGCPNSCAGH-GQCRV----------------SGEGQWECRCYEG 1324
            .:||..           ||..|...||... ||.:|                ||...:.|.....
Zfish   323 YYNGMSWIRTQGTKEMLCTCVGGGISCEEQDGQSQVYGGNSGGQPCVFPFVFSGNTHYSCISEGR 387

  Fly  1325 WDGPDCGIALELNCGDSKDNDKDGLVD--------------------CEDP---------ECCAS 1360
            .||       :|.|..:.|.|.|||..                    |:.|         :|.|.
Zfish   388 SDG-------QLWCSTTSDYDSDGLYSFCTQKNLLVTTRGGNSNGALCQFPFKYNGRNYTDCTAE 445

  Fly  1361 HVCKTSQLCVSAPKPIDVLLRKQPPAITASFFERMKFLIDESSLQNYAKLETFNESIF------- 1418
            ......:.|                ..||.:....|:  ....:..:.::.|.|:.::       
Zfish   446 GRRDGMKWC----------------GTTADYDREQKY--GFCPMAAHEEVCTVNDVMYRVGDEWD 492

  Fly  1419 ---------------------WNYFNASR---SAVIRGRVVTSLGMGLVGVRVSTTTLLEGFTLT 1459
                                 ||..:.::   ..|:.|:               |..:.|.|...
Zfish   493 KRHDTLGHMMRCTCQGNGRGEWNCISHTQLKDQCVVNGQ---------------TYDVNETFDKR 542

  Fly  1460 RDDGWFDLMVNGGGAVTLQFGRAPFR---------PQSRI---VQVPWNEVVIIDLVVMSMSEEK 1512
            .|.|:   |:|   ......||..::         |::::   :...||:|:            :
Zfish   543 HDQGY---MMN---CTCFGQGRGRWKCDAIDQCQEPETKVFYQIGQTWNKVI------------Q 589

  Fly  1513 GLAVTTTHTCFAHDYDLMKPVVLASWKHGFQGACPDRSAILAESQVIQESLQIPGTGLNLVYHSS 1577
            |    |.:.|..:                                         |.|:       
Zfish   590 G----TPYRCSCY-----------------------------------------GNGI------- 602

  Fly  1578 RAAGYLSTIKLQLTPDVIPTSLHLIHLRITIEGILFERIFEADPGIKFTYAWNRLNIYRQRVYGV 1642
               |.::...||.|..|          |:.|                 |.|.|:.|.:..:....
Zfish   603 ---GEMACEPLQSTAPV----------RVII-----------------TEAGNQPNSHPIQWNAP 637

  Fly  1643 TTAVVKVGYQYTDCTDIVWDIQTTKLSGHDMSI-SEVGGWNLDIHHRYNFHEGILQKGDGSNIYL 1706
            .:|.:.   ||.    :.|.::.|:....:::| ..:..:.:.     ....|:..:|...:| |
Zfish   638 PSAHIT---QYI----LKWRVKNTRTPWKEVTIPGHINSYTIS-----GLKAGLTYEGQLISI-L 689

  Fly  1707 RNKPRII-----LTTMGDGHQRPLECPDCDGQATKQRLLAP--------------VALAAAPDGS 1752
            |..||.:     .||.|       .....:|:.|:.|.:..              ::..:|.|  
Zfish   690 RYGPREVTRFDFTTTYG-------SLAKAEGETTQPRQVVDTSESVTEITSNSFVISWVSASD-- 745

  Fly  1753 LFVGDFNYIRRIMTDGSIRTVVKLNATRVSY---------RYHM---ALSPLDGTLYV------- 1798
             .|..|.....:..:|:.:.|:.|..|..|.         ||::   .::|...|..:       
Zfish   746 -TVSGFRVEYELSEEGAQKRVLDLPRTTTSVNIQDLLPGRRYNVDVYEVNPEGDTKLILTTTQTT 809

  Fly  1799 --SDPESHQIIRVRDTN---DYSQPELNWEAVVGSGERCLPGDEAHCGDGALAKDAKLAYPKGIA 1858
              ..|.:|::..|::|:   .:|:|:                        |.....::.|...:.
Zfish   810 APDAPTNHEVSNVQETSIVIRWSKPK------------------------APITGYRVVYTPSVE 850

  Fly  1859 ISSDNILYFADGTNIRMVD-RDGIVSTL----IGNHMHKSHWKPIPCEGTLKLEEMHLRWPTELA 1918
            .||..::.....|::.:.| |.|:...:    :.:::..   :|:..:.:...|:.    |.|:.
Zfish   851 GSSTELILPETQTSVTLGDLRPGLSYNISIYSVEDNLES---EPLVLQASTAGEQQ----PEEIQ 908

  Fly  1919 VSPMDNTLHIIDDHMILRMTPDGRVRVISG---------------RPLHCATASTAYDTDLATHA 1968
             :|.|...:.:.| :.:.:|..|....:||               |||.......||       |
Zfish   909 -APTDLQFYEVTD-VKITITWTGPPNEVSGYRVTFAPVSTDGQAQRPLQLPVTHNAY-------A 964

  Fly  1969 TLVMPQSIAFGPLGELYVAESDSQRINRVRVIGTDGRI--APFAGAESKCNCLERGCDCFEAEHY 2031
            .|:..|.      |.||          |..:....|.:  .|..|.:|             .:..
Zfish   965 ELMRLQP------GTLY----------RFHIYAVSGGVESEPLIGEKS-------------TKPD 1000

  Fly  2032 LATSAKFNTIAALAVTPDSHVHI-----ADQANYRI-RSVMSS---------------IPEASPS 2075
            ..|..:|..|     |.||.:.|     |....||: .|:.||               :|...|.
Zfish  1001 APTDLRFTDI-----TDDSALVIWSFPRAQVTGYRLFISIGSSSPKQLRIPGHKSQYKLPNLQPD 1060

  Fly  2076 REYEIYAPDMQEIYIFN----------------RFGQHVS-TRNILTGETTYVFTYNVN---TSN 2120
            .||.:.....|...:..                ||...|: |..|:|......|:|.::   :.:
Zfish  1061 TEYRVTLHSEQGNTLSEGITDTFRTTQPTGNAPRFNTEVTDTAIIVTWIPVAKFSYRMSVKPSQS 1125

  Fly  2121 GKLSTVTDAAGNKVFL--LRDYTSQVNSIENT-KGQKCRLRMTRMKMLHELSTPDNYNVTYEYHG 2182
            |:......:...::::  |......:.|::.. .|:|....:|. |::..||.|.:.||  |.:.
Zfish  1126 GETPREETSGSGRIYISGLTPGLEYIYSLQPLFSGRKHGSPITN-KVVTSLSPPTDLNV--EPNS 1187

  Fly  2183 PTGLLRTKLDSTGRSYVYNYDEFGRLTSAVTPTGRVIELSFDLSVKGAQVK-VSENAQKEMSLLI 2246
            ..|.|..:...|....:..|    |:|.  ||......:|.:.||:|.:.. :.||....:...|
Zfish  1188 VNGELNVRWRGTKSPDITGY----RVTG--TPINGQRGVSLEESVRGDETSCILENLSPGVDYNI 1246

  Fly  2247 QGATVIVRNGAAESRTTVDMD------------GSTTSITPWGHNLQMEVAPYTILAEQSPLLGE 2299
            ...||.....:....|:|..|            ..||....|.......|..|.|....|   |:
Zfish  1247 SVYTVKNHLESEPISTSVTQDVPKVGDLSFVDFTDTTIGIRWTPLKYQAVTGYHITVVTS---GQ 1308

  Fly  2300 SYPVPAKQRTEIAGDLANRFEWRYFVRRQQPLQAGKQSKGPPRPVTEVGRKLRVNGDNVLTLEYD 2364
            ::|        |..|:.|.....|.:|..:|                             .:.||
Zfish  1309 NFP--------ILEDVVNSSVNYYTIRGLEP-----------------------------GINYD 1336

  Fly  2365 RETQSVVVMVDDKQELLNVTYDRTSRPISFRPQSGDYADVDLEYDRFG---RLVSWKWGVLQEA- 2425
               .||..:.|:.:.:.:|...:|        |:...|..:|.....|   ..|||....:|.: 
Zfish  1337 ---ISVSTITDEAESVPSVITQQT--------QTAVPAPTNLYISEVGADSMHVSWTAPSVQPSE 1390

  Fly  2426 --------YSFDRNGRLNEIKYGDGSTMVYAFKDMFGSLPLKVTTPRRSDYLLQ----YDDAGAL 2478
                    :..:.:....|:..|.|:|          |..|:...| .::||::    |||..: 
Zfish  1391 ISRFVIRYHPTNNDDDTQEVNVGGGTT----------SFVLQNLLP-NTEYLVKVVCVYDDRES- 1443

  Fly  2479 QSLTTPRGHIHAFSLQTSLGFFKYQYYSPINRHPFEILYNDEGQILAKIHPHQSGKVAF-VHDTA 2542
                           :...|..|.:..||.|....::..|                 :| ||..|
Zfish  1444 ---------------EPVTGIQKTKLDSPTNLDFSDVSTN-----------------SFTVHWMA 1476

  Fly  2543 GRLETILAGLSSTHYTYQDTTSLVKSVEVQEPGFELRREFKYHAGILKDEKL-----RFGSKNSL 2602
            .|     |.::.....||.|:                      .|..|||:|     .|...|..
Zfish  1477 PR-----AVITGYRLRYQPTS----------------------GGRAKDERLPPTRNYFTLVNLA 1514

  Fly  2603 ASARYK---YAYDGNAR---LSGIEMAIDDKELPTTRYKYSQNLGQLEV--------VQDLKITR 2653
            ....|.   ||...|..   |:|.:..:.|  .||.....|.....:.:        |:..|||.
Zfish  1515 PETEYTVHIYAVSSNIESLPLTGTQATVSD--APTDLAVTSSTPTSITISWDAPAVTVRYYKITH 1577

  Fly  2654 NAFNRTVIQDSAKQF-------------------FAIVDYDQHGRVKSVLMNVKNIDVFRL---- 2695
               ..|..:|:.::|                   :.|..|...||..|...:...|...|.    
Zfish  1578 ---GETGERDAPREFTVPGTQSSATIQGLRPDTDYTITLYAVTGRGDSPASSTPVIITHRTAGGS 1639

  Fly  2696 -----ELDY-DLRNRIKS----------------------QKTTFGRSTAFDKINYNADGHVVEV 2732
                 :||. |:::...:                      |..||......::......|.|..|
Zfish  1640 IASPSDLDVTDIQDNTLTVRWTPARGPITGYRVTGTPKGGQGPTFSELVGPERTEMTIHGLVPTV 1704

  Fly  2733 LGTNNWKYLFDENGNTVGVVDQGEKFNLGYDIGDRVIKVGDVEFNNYDARGFVVK------RGEQ 2791
            ..|.|...|..| |.:..||.:....|        ..|..|:.|.:.|:...:||      .|..
Zfish  1705 EYTINVVALSQE-GESTPVVQKATTTN--------EQKPKDLTFTDVDSTSMLVKWNVPRVPGVT 1760

  Fly  2792 KYRYNNRGQLIHSF----ERERFQSWYYYDDRSRLVAWHDNKGNTTQYYYANPRTPHLVTHVHFP 2852
            .||      :::|.    |||      |....|       .:.|:......||.|.:::..:   
Zfish  1761 SYR------VLYSSPEEGERE------YQPALS-------GRDNSVLLQGLNPGTMYIIKVI--- 1803

  Fly  2853 KISRTMKLFYDDRDMLIALEHEDQRYYVATDQNGSP----LAFFDQNGSIVKEMKRTPFGRIIKD 2913
                .||    .|:.|..||...|.....|.:...|    :.|||.:.|......:.|..|    
Zfish  1804 ----PMK----GRNPLQTLEGIQQTIQEDTQRIAVPAPTDIQFFDISPSSFIVSWQAPNSR---- 1856

  Fly  2914 TKPEFFVPIDFHGGLIDPHTKLVYTEQRQYDPHVGQWMTPLWETLATEMSHPTDVFIYRYHNNDP 2978
                    :..:..::.|..:|..:::....|...|.:.|     ...::.|.:|.:|....:|.
Zfish  1857 --------LSGYRVVVTPRNQLATSKEMTISPDSTQVLVP-----GLVVATPYNVHVYALRGSDS 1908

  Fly  2979 INP 2981
            ..|
Zfish  1909 SPP 1911

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ten-mNP_001262211.1 TNFRSF 1069..1198 CDD:304602 35/149 (23%)
CRD2 1106..1151 CDD:276900 12/45 (27%)
EGF_2 1139..1162 CDD:285248 6/22 (27%)
Keratin_B2 1162..1330 CDD:279797 50/218 (23%)
EGF_2 1167..1194 CDD:285248 7/28 (25%)
DUF3844 1171..>1235 CDD:289707 17/77 (22%)
EGF_2 <1272..1294 CDD:285248 9/38 (24%)
NHL 1750..2065 CDD:302697 63/366 (17%)
NHL repeat 1784..1830 CDD:271320 10/60 (17%)
NHL repeat 1854..1888 CDD:271320 6/38 (16%)
NHL repeat 1911..1950 CDD:271320 9/53 (17%)
NHL repeat 1972..2005 CDD:271320 5/32 (16%)
NHL repeat 2039..2065 CDD:271320 8/31 (26%)
RHS_repeat 2183..2218 CDD:283287 8/34 (24%)
RhsA 2347..3020 CDD:225750 134/736 (18%)
YD_repeat_2x 2795..2836 CDD:273728 7/44 (16%)
Rhs_assc_core 2905..2980 CDD:274730 11/74 (15%)
Tox-GHH 3193..3268 CDD:292269
fn1bXP_009303829.1 FN1 57..93 CDD:238018
fn1 101..139 CDD:278468 6/24 (25%)
fn1 145..183 CDD:278468 11/44 (25%)
FN1 190..234 CDD:214494 16/54 (30%)
fn1 235..274 CDD:278468 11/59 (19%)
FN2 361..409 CDD:128373 12/54 (22%)
FN2 421..469 CDD:128373 8/65 (12%)
fn1 478..516 CDD:278468 3/37 (8%)
fn1 529..563 CDD:278468 10/54 (19%)
fn1 569..607 CDD:278468 10/104 (10%)
fn3 614..688 CDD:278470 15/112 (13%)
fn3 727..798 CDD:278470 12/73 (16%)
fn3 812..891 CDD:278470 14/105 (13%)
fn3 909..990 CDD:278470 20/104 (19%)
fn3 1000..1077 CDD:278470 18/81 (22%)
fn3 1097..1155 CDD:278470 9/57 (16%)
fn3 1176..1259 CDD:278470 22/90 (24%)
fn3 1269..1351 CDD:278470 20/124 (16%)
FN3 1362..1450 CDD:238020 20/114 (18%)
fn3 1455..1534 CDD:278470 24/122 (20%)
fn3 1544..1625 CDD:278470 16/85 (19%)
fn3 1643..1721 CDD:278470 14/78 (18%)
fn3 1733..1803 CDD:278470 19/88 (22%)
fn3 1831..1911 CDD:278470 16/96 (17%)
fn3 1924..2004 CDD:278470
FN3 2019..2104 CDD:238020
fn3 2236..2298 CDD:278470
fn1 2325..2364 CDD:278468
FN1 2370..2412 CDD:214494
FN1 2413..2452 CDD:238018
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1225
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.900

Return to query results.
Submit another query.